Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Assessment of Cardiovascular Risk by Use of Multiple-Risk-Factor Assessment Equations

1999 • 1,333 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation.

1985 • 714 citations

Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

1977 • 654 citations

Determinants of atherosclerosis in the young

1998 • 537 citations

The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations.

1991 • 507 citations

Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis.

1992 • 453 citations

Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.

1987 • 422 citations

Apolipoprotein E polymorphism in health and disease

1987 • 391 citations

A survey of 246 suggested coronary risk factors

1981 • 364 citations

Apolipoprotein E: an important gene and protein to follow in laboratory medicine

1995 • 352 citations

Apolipoprotein E polymorphism and coronary artery disease.

1983 • 352 citations

Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.

1991 • 291 citations

Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism.

1992 • 251 citations

Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease

1993 • 249 citations

The Apolipoprotein ε4 Allele Determines Prognosis and the Effect on Prognosis of Simvastatin in Survivors of Myocardial Infarction

2000 • 236 citations

Apolipoprotein E Polymorphism Predicts Death From Coronary Heart Disease in a Longitudinal Study of Elderly Finnish Men

1995 • 228 citations

Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study.

1994 • 222 citations

Structure and evolution of the apolipoprotein multigene family

1986 • 214 citations

Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study.

1990 • 205 citations

Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study.

1994 • 204 citations

Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia

1998 • 189 citations

Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease.

1986 • 189 citations

Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.

1994 • 179 citations

Introduction:Structure and metabolism of plasma lipoproteins.

1995 • 177 citations

Age-Dependent Association of Apolipoprotein E Genotype With Coronary and Aortic Atherosclerosis in Middle-Aged Men

1999 • 169 citations

Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

1993 • 162 citations

Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease

1995 • 161 citations

Apolipoprotein E4 homozygosity predisposes to serum cholesterol elevation during high fat diet.

1990 • 154 citations

Genetic studies of human apolipoproteins

1989 • 150 citations

Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project

2000 • 143 citations

Apolipoprotein E polymorphism and hyperlipidemia.

1984 • 137 citations

WHO MONICA Project: Objectives and Design

1989 • 130 citations

Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women

1995 • 130 citations

Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes.

1992 • 120 citations

Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects

1995 • 117 citations

Gene-diet interaction in determining plasma lipid response to dietary intervention

1995 • 116 citations

Polymorphism of the Apolipoprotein E Gene and Early Carotid Atherosclerosis Defined by Ultrasonography in Asymptomatic Adults

1997 • 116 citations

Polymorphisms of the Apolipoprotein E Gene and Severity of Coronary Artery Disease Defined by Angiography

1995 • 109 citations

Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol

1998 • 106 citations

Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis.

1995 • 105 citations

An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E

1998 • 91 citations

Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol.

1991 • 88 citations

Increased frequencies of apolipoprotein ε2 and ε4 alleles in patients with ischemic heart disease

1989 • 85 citations

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia

1990 • 84 citations

Apolipoprotein E and ALzheimer's Disease: The Tip of the Susceptibility Iceberg

1998 • 82 citations

Association of Apolipoprotein E Phenotype with Plasma Lipoproteins in African-American and White Young Adults: The CARDIA Study

1998 • 77 citations

Two-dimensional gel studies of genetic variation in the plasma proteins of Amerindians and Japanese

1985 • 76 citations

Association of Apolipoprotein ε2 Allele With Diabetic Nephropathy in Caucasian Subjects With IDDM

1998 • 76 citations

A comparative study of the efficacy of simvastatin and gemfibrozil in combined hyperlipoproteinemia: prediction of response by baseline lipids, apo E genotype, lipoprotein(a) and insulin

1997 • 76 citations

Apolipoprotein E 4 Allele as a Genetic Risk Factor for Left Ventricular Failure in Homozygous β-Thalassemia

1998 • 75 citations

Apolipoprotein E Polymorphism in American Indians and Its Relation to Plasma Lipoproteins and Diabetes

1996 • 75 citations

Localization of genes encoding apolipoproteins CI, CII, and E to the p13?cen region of human chromosome 19

1985 • 73 citations

Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks.

1989 • 72 citations

Angiotensin-Converting Enzyme and Apolipoprotein E Genotypes and Restenosis After Coronary Angioplasty

1995 • 70 citations

Apolipoprotein E polymorphism and plasma cholesterol response to probucol

1987 • 70 citations

The effect of physical activity on serum total and low-density lipoprotein cholesterol concentrations varies with apolipoprotein E phenotype in male children and young adults: The cardiovascular risk in young finns study

1996 • 63 citations

Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men

1993 • 60 citations

Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas.

1991 • 59 citations

Genetics of Variability of CHD Risk

1989 • 57 citations

Aetiology of peripheral atherosclerosis.

1989 • 51 citations

Apolipoprotein E polymorphism and its association with serum lipoprotein concentrations in black versus white children: The Bogalusa Heart Study

1993 • 51 citations

Apolipoprotein E4 in Parkinson Disease and Dementia

1998 • 51 citations

Disparity between apolipoprotein E phenotypes and genotypes (as determined by polymerase chain reaction and oligonucleotide probes) in patients with non-insulin-dependent diabetes mellitus

1991 • 43 citations

ApoE Genotype Does Not Predict Lipid Response to Changes in Dietary Saturated Fatty Acids in a Heterogeneous Normolipidemic Population

1997 • 38 citations

Apolipoprotein E Genotype and Schizophrenia

1999 • 29 citations

High prevalence of serum apolipoprotein E4 isoprotein in rheumatoid arthritis patients with amyloidosis

1996 • 28 citations

Psychotic symptoms and apolipoprotein E genotypes in an elderly population

1998 • 26 citations

Role of Factor V Leiden Mutation in Patients with Angiographically Demonstrated Coronary Artery Disease

1998 • 23 citations

Angiotensin-converting enzyme gene polymorphism in a cohort of coronary angiography patients

2001 • 22 citations

Apolipoprotein E allele frequencies in non-insulin-dependent diabetes mellitus with hypertriglyceridemia (type IIb, III, IV, and V hyperlipoproteinemia)

1991 • 18 citations

The impact of the apolipoprotein E polymorphism on the lipoprotein profile in insulin-dependent diabetes: The pittsburgh epidemiology of diabetes complications study IX

1992 • 13 citations

Apolipoprotein E to B Ratio: A Marker for Type III Hyperlipoproteinaemia

1993 • 11 citations

Regional serum cholesterol differences in Belgium: do genetically determined cardiovascular risk factors contribute?

1998 • 10 citations