The clinical pharmacology of 6-mercaptopurine

Dithiothreitol, a New Protective Reagent for SH Groups^*

1964 • 1,933 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Treatment of Crohn's Disease with 6-Mercaptopurine

1980 • 1,055 citations

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1990 • 657 citations

Xanthine oxidase: biochemistry, distribution and physiology.

1986 • 635 citations

Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

1989 • 605 citations

Prolonged Survival of Human-Kidney Homografts by Immunosuppressive Drug Therapy

1963 • 544 citations

Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases

1953 • 379 citations

Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties

1978 • 351 citations

CONTROLLED TRIAL OF AZATHIOPRINE IN CROHN'S DISEASE

1971 • 316 citations

The Metabolic Basis of Inherited Disease

1990 • 302 citations

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 284 citations

Variable Bioavailability of Oral Mercaptopurine

1983 • 268 citations

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1991 • 258 citations

Variability in caffeine metabolism

1983 • 255 citations

Effect of 6-Mercaptopurine on Antibody Production.

1958 • 253 citations

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.

1989 • 251 citations

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

Drug dosage and remission duration in childhood lymphocytic leukemia

1971 • 238 citations

A STUDY OF THE EFFECTS OF DRUGS IN PROLONGING SURVIVAL OF HOMOLOGOUS RENAL TRANSPLANTS IN DOGS*

1962 • 229 citations

Overview of azathioprine treatment in multiple sclerosis

1991 • 222 citations

Minimal Residual Disease in Childhood B-Lineage Lymphoblastic Leukemia

1990 • 211 citations

CONTROLLED TRIAL OF AZATHIOPRINE IN CROHN'S DISEASE

1971 • 183 citations

Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease

1991 • 175 citations

Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol

1983 • 172 citations

Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease

1990 • 160 citations

Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation.

1980 • 156 citations

NEONATAL COAGULATION

1975 • 152 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

1983 • 146 citations

Systemic Exposure to Mercaptopurine as a Prognostic Factor in Acute Lymphocytic Leukemia in Children

1990 • 139 citations

Sulphur-containing Drugs and Related Organic Compounds

1991 • 135 citations

Purification and properties of 5-phosphoribosylpyrophosphate amidotransferase from adenocarcinoma 755 cells

1969 • 131 citations

Azathioprine Metabolism: Pharmacokinetics of 6‐Mercaptopurine, 6‐Thiouric Acid and 6‐Thioguanine Nucleotides in Renal Transplant Patients

1990 • 121 citations

Human liver xanthine oxidase: Nature and extent of individual variation

1991 • 115 citations

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1983 • 112 citations

Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies.

1982 • 106 citations

Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity

1982 • 100 citations

Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells

1985 • 99 citations

Assignment of Nucleoside Phosphorylase to D-14 and Localization of X-linked Loci in Man by Somatic Cell Genetics

1973 • 99 citations

Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells

1987 • 98 citations

Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations

1986 • 92 citations

Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin.

1984 • 82 citations

Phase I and clinical pharmacological study of mercaptopurine administered as a prolonged intravenous infusion.

1985 • 80 citations

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 78 citations

Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment

1986 • 75 citations

Chromatographic analysis of anticancer drugs

1990 • 75 citations

The effect of methotrexate on the bioavailability of oral 6-mercaptopurine

1987 • 74 citations

6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells.

1984 • 74 citations

Thiation of Nucleosides. III. Oxidation of 6-Mercaptopurines¹

1961 • 74 citations

A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells

1985 • 71 citations

Mechanisms of Action of Drugs Affecting Immune Responses

1972 • 67 citations

A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6‐thioguanine, 6‐mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy

1990 • 67 citations

Pharmacogenetics of methylation: Relationship to drug metabolism

1988 • 64 citations

Azathioprine metabolism in kidney transplant recipients.

1984 • 63 citations

The Effects of Azathioprine and 6 mp on Immunity

1979 • 60 citations

Effect of allopurinol on caffeine disposition in man.

1986 • 55 citations

Comparison between Mice Chimaeric and Heterozygous for the X-linked Gene tabby

1973 • 55 citations

QUANTITATION OF PLASMA AZATHIOPRINE AND 6-MERCAPTOPURINE LEVELS IN RENAL TRANSPLANT PATIENTS

1980 • 54 citations

Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts

1986 • 52 citations

PHOTOCHEMICAL SENSITIZATION BY AZATHIOPRINE AND ITS METABOLITES—I. 6‐MERCAPTOPURINE

1986 • 52 citations

Maintenance chemotherapy and cure of childhood acute lymphoblastic leukaemia

1991 • 52 citations

Importance of 6-mercaptopurine dose in lymphoblastic leukaemia.

1991 • 50 citations

Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction.

1972 • 50 citations

Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine.

1971 • 48 citations

ARE CHILDREN WITH LYMPHOBLASTIC LEUKAEMIA GIVEN ENOUGH 6-MERCAPTOPURINE?

1987 • 48 citations

Serum azathioprine and 6-mercaptopurine levels and immunosuppressive activity after azathioprine in uremic patients

1986 • 48 citations

Prolonged Survival of Human-Kidney Homografts by Immunosuppressive Drug Therapy

1984 • 44 citations

6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia

1990 • 44 citations

ENHANCEMENT OF UV‐INDUCED SKIN CARCINOGENESIS BY AZATHIOPRINE: ROLE OF PHOTOCHEMICAL SENSITISATION

1989 • 43 citations

6-Mercaptopurine Plasma Levels in Children with Acute Lymphoblastic Leukemia

1989 • 40 citations

Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia

1990 • 39 citations

Azathioprine, a genotoxic agent to be considered non-genotoxic in man

1989 • 38 citations

Liver damage in children with acute leukaemia and non-Hodgkin's lymphoma on oral maintenance chemotherapy

1980 • 38 citations

Effect of methylthioinosine on nucleotide concentrations in L5178Y cells.

1973 • 38 citations

Studies on the mechanism of formation of 5-mercapto-1-methyl-4-nitroimidazole, a metabolite of the immunosuppressive drug azathioprine

1974 • 34 citations

Pyrroline-5-carboxylate stimulates the conversion of purine antimetabolites to their nucleotide forms by a redox-dependent mechanism.

1983 • 32 citations

Double-masked trial of azathioprine in multiple sclerosis. British and Dutch Multiple Sclerosis Azathioprine Trial Group.

1988 • 32 citations

Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes

1989 • 32 citations

Photo-oxidation of 6-mercaptopurine in aqueous solution

1984 • 32 citations

Biochemical parameters of mercaptopurine activity in patients with acute lymphoblastic leukemia.

1986 • 30 citations

Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia

1986 • 30 citations

Effects of azathioprine in a disorder of uric acid metabolism and cerebral function

1968 • 28 citations

A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors

1990 • 27 citations

Studies on the xanthine oxidase activity of mammalian cells

1973 • 25 citations

Azathioprine lymphocytotoxicity. Potentially lethal damage by its imidazole derivatives.

1988 • 25 citations

Selective action of azathioprine on T cells.

1973 • 25 citations

Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia

1991 • 24 citations

A Textbook of Biochemistry

1946 • 24 citations

Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch‐Nyhan syndrome.

1985 • 21 citations

Metabolism of azathioprine to 6‐thioguanine nucleotides in patients with pemphigus vulgaris.

1987 • 21 citations

Leukocyte purine phosphoribosyltransferases in human leukemias sensitive and resistant to 6-thiopurines.

1973 • 21 citations

Rat thiopurine methyltransferase: regulation by testosterone.

1981 • 20 citations

The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man.

1960 • 18 citations

Assay of 6-mercaptopurine in human plasma

1985 • 18 citations

Pharmacokinetics of Oral 6-Mercaptopurine

1990 • 18 citations

Determination of 6-Mercaptopurine in Acute Lymphoblastic Leukemia Patientsʼ Plasma by High-Performance Liquid Chromatography

1991 • 16 citations

A clinically useful ion-pairing high-performance liquid chromatographic assay for the monophosphate metabolites of thioguanine and mercaptopurine in human neoplastic cells

1987 • 14 citations

Metabolism of 6-mercaptopurine in human leukemic cells.

1976 • 11 citations

Modulation of thiopurine cytotoxicity in the HL-60 cell line by physiological concentrations of hypoxanthine.

1986 • 11 citations

Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood.

1986 • 11 citations

A 10-year matched-pairs study comparing azathioprine and no immunosuppression in multiple sclerosis

1990 • 10 citations

Immunosuppressive effects of specific classes of agents with special reference to organ transplantation. Immunosuppression by thiopurines.

1973 • 9 citations

Variables and Paradoxes in “Maintenance” Therapy of Lymphoblastic Leukemia

1991 • 3 citations

Symposia

1988 • 1 citations

Deleted Work

1955 • 0 citations