Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1987 • 345 citations

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 284 citations

Childhood leukaemia: a relationship between intracellular 6‐mercaptopurine metabolites and neutropenia

2004 • 161 citations

Childhood leukaemia: a relationship between intracellular 6‐ mercaptopurine metabolites and neutropenia.

1983 • 155 citations

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1983 • 112 citations

Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies.

1982 • 106 citations

Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity

1982 • 100 citations

Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations

1986 • 92 citations

A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells

1985 • 71 citations

BIOCHEMICAL ASPECTS OF MERCAPTOPURINE INHBITION AND RESISTANCE.

1963 • 65 citations

Severe megaloblastic anaemia associated with abnormal azathioprine metabolism.

1984 • 46 citations

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine

1978 • 45 citations

6-Mercaptopurine: apparent lack of relation between prescribed dose and biological effect in children with leukaemia

1982 • 43 citations

Separation of 6-thiopurine derivatives on deae-sephadex columns and in the high-pressure liquid chromatograph

1973 • 40 citations

Assay of thioinosinic acid, an active metabolite of azathioprine, in human lymphocytes.

1980 • 19 citations

Assay of 6-mercaptopurine in human plasma

1985 • 18 citations

Incorporation of the purine moieties of guanosine and inosine analogs into nucleotide pools of human erythrocytes

1975 • 15 citations

A clinically useful ion-pairing high-performance liquid chromatographic assay for the monophosphate metabolites of thioguanine and mercaptopurine in human neoplastic cells

1987 • 14 citations

Assay of an active metabolite of 6-thioguanine, 6-thioguanosine 5′-monophosphate, in human red blood cells

1982 • 13 citations