Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.

Regression Models and Life-Tables

1992 • 27,454 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1987 • 345 citations

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 284 citations

Variability in caffeine metabolism

1983 • 255 citations

Drug dosage and remission duration in childhood lymphocytic leukemia

1971 • 238 citations

A Reappraisal of the Results of Stopping Therapy in Childhood Leukemia

1979 • 185 citations

Childhood leukaemia: a relationship between intracellular 6‐mercaptopurine metabolites and neutropenia

2004 • 161 citations

Statistics in Medicine: Calculating confidence intervals for regression and correlation

1988 • 160 citations

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1983 • 112 citations

Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells

1987 • 98 citations

Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations

1986 • 92 citations

WHICH TREATMENT FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA IN SECOND REMISSION?

1987 • 91 citations

Acute Lymphoblastic Leukemia in Childhood

1985 • 90 citations

Statistics in Medicine: Calculating confidence intervals for survival time analyses

1988 • 67 citations

Effect of allopurinol on caffeine disposition in man.

1986 • 55 citations

ARE CHILDREN WITH LYMPHOBLASTIC LEUKAEMIA GIVEN ENOUGH 6-MERCAPTOPURINE?

1987 • 48 citations

Influence of Food Intake on Bioavailability of Oral 6-Mercaptopurine in Children with Acute Lymphoblastic Leukemia

1986 • 48 citations

6-Mercaptopurine: apparent lack of relation between prescribed dose and biological effect in children with leukaemia

1982 • 43 citations

Childhood lymphoblastic leukaemia: Sex difference in 6-mercaptopurine utilization

1984 • 35 citations

The effect of food on the oral administration of 6-mercaptopurine

1986 • 29 citations

Studies on the xanthine oxidase activity of mammalian cells

1973 • 25 citations

Identification and partial characterization of the xanthine oxidase transitions of the milk fat globule membrane

1985 • 10 citations