6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells.

A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

1982 • 322 citations

A screening method for isolating DNA repair-deficient mutants of CHO cells

1980 • 287 citations

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 284 citations

Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.

1975 • 240 citations

Single strand interruptions in DNA and the effects of caffeine in Chinese hamster cells irradiated with ultraviolet light

1969 • 221 citations

Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells.

1973 • 197 citations

Inhibition of repair of UV-damaged DNA by caffeine and mutation induction in Chinese hamster cells

1973 • 98 citations

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 78 citations

Unilateral chromatid damage: a new basis for 6-thioguanine cytotoxicity.

1983 • 60 citations

Effects of sulfur substituents on base stacking and hydrogen bonding. Crystal structure of 6-thioguanosine monohydrate

1972 • 60 citations

Effect of Caffeine on Postreplication Repair in Human Cells

1974 • 58 citations

Characteristics of DNA synthesis following ultraviolet light irradiation in mouse L cells

1972 • 56 citations

Thioguanine-induced S and G2 blocks and their significance to the mechanism of cytotoxicity.

1980 • 52 citations

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine

1978 • 45 citations

The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine.

1981 • 34 citations

Differential chromatid damage induced by 6-thioguanine in CHO cells

1981 • 30 citations

The effects of beta-2'-deoxythioguanosine on survival and progression in mammalian cells.

1971 • 29 citations

Repair Responses to DNA Damage: Enzymatic Pathways in E coli and Human Cells

1982 • 24 citations

Postreplication Repair of Ultraviolet Damage to DNA in Xeroderma Pigmentosum, Other Human and Mouse Cells in Culture

1974 • 16 citations

Suppression of the biosynthesis of guanosine triphosphate by protein synthesis inhibitors.

1980 • 14 citations

A Dual-Column HPLC Method for the Simultaneous Measurement of 6-Thioguanine and Adenine in RNA or DNA

1982 • 13 citations

Metabolism and mechanisms of action of 9-(tetrahydro-2-furyl)-6-mercaptopurine in Chinese hamster ovary cells

1982 • 12 citations

Effects of 6-thiopurines on the transforming activity of Bacillus subtilis deoxyribonucleic acid

1979 • 9 citations

Interactions of 6-thioguanine in B-DNA: Possible mechanism of its mutagenic action

1975 • 8 citations

A caffeine insensitive error-prone repair process in V79 Chinese hamster cells?

1977 • 6 citations

Reduction of DNA transforming activity in culture by 6-mercaptopurine.

1980 • 4 citations