Functions of plasmalogen lipids in health and disease

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

2001 • 528 citations

Lipid Rafts Are Enriched in Arachidonic Acid and Plasmenylethanolamine and Their Composition Is Independent of Caveolin-1 Expression: A Quantitative Electrospray Ionization/Mass Spectrometric Analysis

2002 • 499 citations

Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders

2000 • 494 citations

Functions and biosynthesis of plasmalogens in health and disease

2004 • 380 citations

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

2011 • 355 citations

A possible role for plasmalogens in protecting animal cells against photosensitized killing.

1988 • 344 citations

Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome)

1983 • 340 citations

Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

2011 • 327 citations

Old and new generation lipid mediators in acute inflammation and resolution

2010 • 323 citations

Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers

2010 • 288 citations

EFFECTS OF DIETARY FATS ON HUMAN ERYTHROCYTE FATTY ACID PATTERNS*

1963 • 281 citations

Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids

2004 • 262 citations

The alk-1-enyl group content of mammalian myelin phosphoglycerides by quantitative two-dimensional thin-layer chromatography

1968 • 254 citations

Mammalian Wax Biosynthesis

2004 • 250 citations

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

2007 • 237 citations

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1995 • 230 citations

Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia

2001 • 220 citations

Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether

1999 • 214 citations

Mechanisms of glycerophospholipid homeostasis in mammalian cells

2011 • 202 citations

Ether lipids in biomembranes

1994 • 201 citations

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

2010 • 194 citations

Alzheimer’s disease: the lipid connection

2007 • 191 citations

Peroxisomal alterations in Alzheimer’s disease

2011 • 188 citations

Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

1985 • 184 citations

Adult rat brain synaptic vesicles II. Lipid composition

1973 • 181 citations

The protective role of plasmalogens in iron-induced lipid peroxidation

1999 • 175 citations

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

2011 • 175 citations

Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease

2005 • 174 citations

Identification of PEX7 as the Second Gene Involved in Refsum Disease

2003 • 162 citations

Circulating plasmalogen levels and Alzheimer Disease Assessment Scale–Cognitive scores in Alzheimer patients

2010 • 150 citations

Use of three‐dimensional ultrasound imaging in the diagnosis of prenatal‐onset skeletal dysplasias

2003 • 147 citations

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

2011 • 143 citations

Zellweger syndrome: Diagnostic assays, syndrome delineation, and potential therapy

1986 • 142 citations

Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs

1990 • 135 citations

Mutation analysis ofPEX7 in 60 probands with rhizomelic chondrodysplasia punctata and functional correlations of genotype with phenotype

2002 • 128 citations

The appearance, disappearance and reappearance of plasmalogens in evolution

2010 • 127 citations

Impaired membrane traffic in defective ether lipid biosynthesis

2001 • 123 citations

Natural history of rhizomelic chondrodysplasia punctata

2003 • 122 citations

Metabolic Profiling Reveals Distinct Variations Linked to Nicotine Consumption in Humans — First Results from the KORA Study

2008 • 117 citations

Posttranslational Regulation of Fatty Acyl-CoA Reductase 1, Far1, Controls Ether Glycerophospholipid Synthesis

2010 • 114 citations

Biosynthesis and possible biological functions of plasmalogens

1998 • 114 citations

Alkyl-Glycerol Rescues Plasmalogen Levels and Pathology of Ether-Phospholipid Deficient Mice

2011 • 112 citations

Phospholipid composition and levels are altered in down syndrome brain

2000 • 108 citations

Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport

2003 • 104 citations

Plasmalogen synthesis is regulated via alkyl‐dihydroxyacetonephosphate‐synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

2011 • 103 citations

Plasmalogens participate in very-long-chain fatty acid-induced pathology

2008 • 102 citations

Plasmalogens in Human Serum Positively Correlate with High- Density Lipoprotein and Decrease with Aging

2007 • 102 citations

MRI of the brain and cervical spinal cord in rhizomelic chondrodysplasia punctata

2006 • 95 citations

Increasing plasmalogen levels protects human endothelial cells during hypoxia

2002 • 93 citations

Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents

1992 • 93 citations

Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity

2004 • 93 citations

Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine

1990 • 90 citations

MALDI imaging MS of phospholipids in the mouse lung

2011 • 89 citations

Peroxisomal Impairment in Niemann-Pick Type C Disease

1997 • 86 citations

Chondrodysplasia punctata — Rhizomelic form

1976 • 84 citations

Lipid remodelling during epididymal maturation of rat spermatozoa. Enrichment in plasmenylcholines containing long-chain polyenoic fatty acids of the n-9 series

1992 • 82 citations

Positions of double bonds in the monounsaturated alk-1-enyl groups from the plasmalogens of human heart and brain

1971 • 81 citations

Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin

2008 • 79 citations

Influence of plasmalogen deficiency on membrane fluidity of human skin fibroblasts: a fluorescence anisotropy study

1989 • 78 citations

Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia

2010 • 77 citations

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

2011 • 76 citations

The structure of plasmalogens IV. Lipids in normal and neoplastic tissues of man and in normal tissues of rabbit and rat

1959 • 75 citations

Meats and Fish Consumed in the American Diet Contain Substantial Amounts of Ether-Linked Phospholipids

1992 • 73 citations

Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3

2011 • 71 citations

The pathology of peroxisomal disorders with pathogenetic considerations.

1995 • 71 citations

Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat

2002 • 70 citations

Plasmalogen degradation by oxidative stress: production and disappearance of specific fatty aldehydes and fatty α-hydroxyaldehydes

2001 • 70 citations

Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts

1995 • 70 citations

Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: Localization and transport of plasmalogens to post-Golgi compartments

2008 • 69 citations

The Vinyl Ether Linkages of Plasmalogens Are Favored Targets for Myeloperoxidase-Derived Oxidants: A Kinetic Study

2008 • 68 citations

Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment

2004 • 67 citations

Plasmalogen Phospholipids Are Involved in HDL-Mediated Cholesterol Efflux: Insights from Investigations with Plasmalogen-Deficient Cells

1998 • 66 citations

PRESIDENTIAL ADDRESS

1995 • 65 citations

Preterm infants with high polyunsaturated fatty acid and plasmalogen content in tracheal aspirates develop bronchopulmonary dysplasia less often

2000 • 63 citations

Rhizomelic chondrodysplasia punctata: Clinical, pathologic, and biochemical findings in two patients

1988 • 63 citations

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

2010 • 61 citations

Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism.

1982 • 60 citations

Identification of Abundant Alkyl Ether Glycerophospholipids in the Human Lens by Tandem Mass Spectrometry Techniques

2009 • 59 citations

Plasmalogens, Docosahexaenoic Acid and Neurological Disorders

2003 • 57 citations

Plasmalogen and anionic phospholipid dependence of the cardiac sarcolemmal sodium‐calcium exchanger

1996 • 56 citations

Involvement of Cytosolic Phospholipase A2, Calcium Independent Phospholipase A2 and Plasmalogen Selective Phospholipase A2 in Neurodegenerative and Neuropsychiatric Conditions

2010 • 56 citations

The Intestinal Absorption and Metabolism of Chimyl Alcohol in the Rat.

1957 • 52 citations

Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities

1999 • 52 citations

Inflammatory, Apoptotic, and Survival Gene Signaling in Alzheimer’s Disease

2010 • 51 citations

Purification, Identification, and Cloning of Lysoplasmalogenase, the Enzyme That Catalyzes Hydrolysis of the Vinyl Ether Bond of Lysoplasmalogen

2011 • 50 citations

Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether

1999 • 50 citations

Low-Concentration Ozone Reacts with Plasmalogen Glycerophosphoethanolamine Lipids in Lung Surfactant

2009 • 48 citations

The Crucial Step in Ether Phospholipid Biosynthesis: Structural Basis of a Noncanonical Reaction Associated with a Peroxisomal Disorder

2007 • 47 citations

Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism

1998 • 46 citations

Cervical stenosis secondary to rhizomelic chondrodysplasia punctata

2001 • 45 citations

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

2011 • 44 citations

Photosensitized killing of cultured fibroblasts from patients with peroxisomal disorders due to pyrene fatty acid-mediated ultraviolet damage.

1991 • 42 citations

The ether lipid trail: a historical perspective1The original citations of the literature covered in this article only serve as a point of reference and are not intended to be all inclusive. For more comprehensive information about a given subject, the reader should consult the references cited in the review articles and books listed in this article or to search Medline or some similar database for the individual scientists mentioned only by last names and their initials in this review.1

1999 • 40 citations

Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures

1998 • 38 citations

Peroxisomal Disease Cell Lines with Cellular Plasmalogen Deficiency Have Impaired Muscarinic Cholinergic Signal Transduction Activity and Amyloid Precursor Protein Secretion

1998 • 38 citations

In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor

2011 • 36 citations

Topography of ether phospholipid biosynthesis

1989 • 36 citations

Alkyl‐dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes

1999 • 36 citations

Dietary supplementation with ether‐linked lipids and tissue lipid composition

1991 • 33 citations

Phospholipid analysis of human eosinophils: High levels of alkylacylglycerophosphocholine (PAF precursor)

1988 • 32 citations

Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology

2009 • 32 citations

Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo

2010 • 31 citations

The structure of pig heart plasmalogens

1957 • 31 citations

Oral ether lipid therapy in patients with peroxisomal disorders

1987 • 29 citations

Fatty Alcohol Accumulation in the Autosomal Recessive Form of Rhizomelic Chondrodysplasia Punctata

1993 • 28 citations

Rhizomelic Chondrodysplasia Punctata Type 1

2012 • 27 citations

Delayed myelination in a rhizomelic chondrodysplasia punctata case: MR spectroscopy findings

2003 • 25 citations

An Animal Cell Mutant with a Deficiency in Acyl/Alkyl-dihydroxyacetone-phosphate Reductase Activity

1997 • 24 citations

Ether-linked phosphoglyceride content of human leukemia cells.

1990 • 22 citations

Plasmalogens and oxidative stress: evidence against a major role of plasmalogens in protection against the superoxide anion radical

1997 • 21 citations

Arachidonic acid metabolism in fibroblasts from patients with peroxisomal diseases: response to interleukin 1

1990 • 20 citations

Fatty alcohol synthesis accompanied with chain elongation in liver peroxisomes

1997 • 20 citations

Plasmalogen levels in full‐term neonates

2009 • 17 citations

Plasmalogen content and β-adrenoceptor signalling in fibroblasts from patients with Zellweger syndrome. Effects of hexadecylglycerol

2002 • 17 citations

Plasmalogen Deficit: A New and Testable Hypothesis for the Etiology of Alzheimer’s Disease

2011 • 16 citations

Identification of PEX7 as the Second Gene Involved in Refsum Disease

2003 • 15 citations

ALKOXYGLYCEROLS AND THEIR USE IN RADIATION TREATMENT. AN EXPERIMENTAL AND CLINICAL STUDY.

1963 • 15 citations

Chondrodysplasia punctata (rhizomelic type): case report and pathologic findings.

1974 • 15 citations

Administration of Myo-inositol Plus Ethanolamine Elevates Phosphatidylethanolamine Plasmalogen in the Rat Cerebellum

2005 • 14 citations

Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology

2011 • 11 citations

Myocardial Salvage by Chimyl Alcohol: Possible Role of Peroxisomal Dysfunction in Reperfusion Injury

1994 • 7 citations

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

1997 • 5 citations

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