Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

A Heteroskedasticity-Consistent Covariance Matrix Estimator and a Direct Test for Heteroskedasticity

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Longitudinal data analysis using generalized linear models

1986 • 17,084 citations

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2005 • 2,251 citations

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2007 • 1,796 citations

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2005 • 852 citations

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

2005 • 828 citations

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2004 • 724 citations

Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model

2004 • 698 citations

The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase.

1991 • 660 citations

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

2005 • 659 citations

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

1991 • 645 citations

Dietary omega 3 fatty acids and the developing brain

2008 • 603 citations

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

2001 • 528 citations

Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids.

1995 • 510 citations

Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.

1989 • 437 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

2006 • 343 citations

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

2007 • 311 citations

Fish, docosahexaenoic acid and Alzheimer’s disease

2009 • 297 citations

Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver

2007 • 283 citations

DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You

2005 • 270 citations

Docosahexaenoic Acid and the Aging Brain

2008 • 240 citations

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

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Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

1999 • 220 citations

Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders

1992 • 187 citations

Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease

2009 • 183 citations

Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

1995 • 160 citations

Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects

1993 • 136 citations

Abnormal content of n−6 and n−3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content

1998 • 123 citations

Severe deficiency of docosahexaenoic acid in peroxisomal disorders

1990 • 100 citations

Peroxisomal Straight-chain Acyl-CoA Oxidase and D-bifunctional Protein Are Essential for the Retroconversion Step in Docosahexaenoic Acid Synthesis

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Nutrition and the Brain

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Physiological Role of D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein

1997 • 81 citations

Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in usher's syndrome

1986 • 79 citations

Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis

2010 • 66 citations

Fat Intake and CNS Functioning: Ageing and Disease

2009 • 64 citations

Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA?

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Lipid abnormalities in the brain in adult Down’s syndrome and Alzheimer’s disease

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Catalase turnover in rat liver and kidney as a function of age

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Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.

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