New insights into BDNF function in depression and anxiety

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

A Neurotrophic Model for Stress-Related Mood Disorders

2006 • 3,154 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

2006 • 1,997 citations

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

2006 • 1,724 citations

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

2002 • 1,627 citations

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

1995 • 1,429 citations

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

2003 • 1,356 citations

Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior

2006 • 1,289 citations

The yin and yang of neurotrophin action

2005 • 1,279 citations

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

2003 • 1,212 citations

Untreated Depression and Hippocampal Volume Loss

2003 • 1,140 citations

Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication

2001 • 1,137 citations

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

1996 • 1,104 citations

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

2004 • 1,084 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

2005 • 927 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)

1997 • 829 citations

Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects

2003 • 783 citations

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

2005 • 770 citations

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 • 604 citations

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

2002 • 570 citations

Alterations in 5-HT _1B Receptor Function by p11 in Depression-Like States

2006 • 554 citations

Behavioural stress facilitates the induction of long-term depression in the hippocampus

1997 • 501 citations

Brain-Derived Neurotrophic Factor Conditional Knockouts Show Gender Differences in Depression-Related Behaviors

2006 • 493 citations

Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention

2004 • 414 citations

Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression

2003 • 397 citations

Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

2005 • 386 citations

Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus

2000 • 362 citations

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1999 • 335 citations

Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects

2006 • 327 citations

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine

2005 • 295 citations

The p75 Neurotrophin Receptor Negatively Modulates Dendrite Complexity and Spine Density in Hippocampal Neurons

2005 • 281 citations

Differential regulation of Brain Derived Neurotrophic Factor transcripts by antidepressant treatments in the adult rat brain

2003 • 274 citations

Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins

2006 • 248 citations

Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus

2005 • 216 citations

p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure

1999 • 214 citations

Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.

2001 • 184 citations

Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression.

2001 • 181 citations

The neurotrophin receptor p75 ^NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus

2005 • 171 citations

Enhanced Long-Term Synaptic Depression in an Animal Model of Depression

2006 • 168 citations

Annexin II: a plasminogen-plasminogen activator co-receptor

2002 • 158 citations

Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”

2003 • 143 citations

Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo

2005 • 129 citations

Loss of brain‐derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice

2005 • 123 citations

Protective and damaging effects of stress mediators: central role of the brain

2000 • 119 citations

Distribution and localization of pro‐brain‐derived neurotrophic factor‐like immunoreactivity in the peripheral and central nervous system of the adult rat

2004 • 82 citations

Gene expression profiling in the hippocampus of learned helpless and nonhelpless rats

2005 • 37 citations