Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

2000 • 1,215 citations

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

2001 • 1,152 citations

Trk receptors: mediators of neurotrophin action

2001 • 1,051 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

1997 • 994 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

2005 • 927 citations

Sortilin is essential for proNGF-induced neuronal cell death

2004 • 926 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Neurotrophin signaling through the p75 neurotrophin receptor

2002 • 686 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches

1997 • 523 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

1998 • 476 citations

The Precursor Pro-Nerve Growth Factor Is the Predominant Form of Nerve Growth Factor in Brain and Is Increased in Alzheimer's Disease

2001 • 473 citations

ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury

2002 • 409 citations

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

1990 • 369 citations

Neurotrophin Signaling via Trks and p75

1999 • 356 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Early events in neurotrophin signalling via Trk and p75 receptors

1995 • 314 citations

The many faces of p75NTR

2002 • 309 citations

p75NTR Is Positively Promiscuous

2004 • 298 citations

Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

2000 • 286 citations

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

2004 • 271 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

Increased proNGF Levels in Subjects with Mild Cognitive Impairment and Mild Alzheimer Disease

2004 • 229 citations

Survival of Cholinergic Forebrain Neurons in Developing p75 ^NGFR -Deficient Mice

1996 • 227 citations

The Role of Nerve Growth Factor Receptors in Cholinergic Basal Forebrain Degeneration in Prodromal Alzheimer Disease

2005 • 214 citations

p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure

1999 • 214 citations

Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain

1993 • 212 citations

Absence of p75^NTRCauses Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation

1997 • 206 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

1999 • 192 citations

Mechanisms of p75-mediated Death of Hippocampal Neurons

2002 • 186 citations

Complete Deletion of the Neurotrophin Receptor p75^NTRLeads to Long-Lasting Increases in the Number of Basal Forebrain Cholinergic Neurons

2002 • 167 citations

Apoptosis Induced by p75NTR Overexpression Requires Jun Kinase-Dependent Phosphorylation of Bad

2003 • 164 citations

Astrocytes Are the Major Source of Nerve Growth Factor Upregulation Following Traumatic Brain Injury in the Rat

1998 • 161 citations

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

1999 • 150 citations

Upregulation of Nerve Growth Factor Following Cortical Trauma

1994 • 124 citations

Mesenchymal and Neuronal Cell Expression of the p75 Neurotrophin Receptor Gene Occur by Different Mechanisms

1995 • 118 citations

Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model

2001 • 110 citations

Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75.

1999 • 106 citations

Regulation of β‐nerve growth factor expression by inflammatory mediators in hippocampal cultures

1990 • 99 citations

TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons

1998 • 97 citations

Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice

2000 • 84 citations

Neuroprotective Actions of Dipyridamole on Cultured CNS Neurons

1998 • 68 citations

Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain

2000 • 46 citations

Programmed Cell Death in the Developing Somites Is Promoted by Nerve Growth Factor via Its p75NTR Receptor

2000 • 29 citations

Expression of astroglial nerve growth factor in damaged brain

1994 • 27 citations

Interactions of Interleukin-1 With Neurotrophic Factors in the Central Nervous System: Beneficial or Detrimental?

2005 • 22 citations