Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

1997 • 1,093 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1997 • 853 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation

1983 • 504 citations

Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord

1997 • 500 citations

Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

1997 • 500 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

1994 • 401 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

1996 • 349 citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

1995 • 348 citations

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1999 • 335 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1996 • 325 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway

1995 • 319 citations

Neurotrophin trafficking by anterograde transport

1998 • 317 citations

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

1996 • 286 citations

Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

1991 • 284 citations

Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system

1996 • 284 citations

Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity

1997 • 268 citations

The role of the Schwann cell in trophic support and regeneration

1994 • 265 citations

Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP)

1990 • 232 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS

1998 • 174 citations

BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons

1998 • 171 citations

Are Neurotrophins Synaptotrophins?

1996 • 134 citations

Detection and processing of peripheral myelin protein PMP22 in cultured Schwann cells

1993 • 131 citations

Detection of Brain-derived Neurotrophic Factor in a Vesicular Fraction of Brain Synaptosomes

1997 • 128 citations

Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

1990 • 127 citations

Neurotrophins induce release of neurotrophins by the regulated secretory pathway

1998 • 124 citations

Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus

1995 • 110 citations

Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

1988 • 110 citations

Peptide Processing and Targeting in the Neuronal Secretory Pathway

1991 • 107 citations

Neurotrophin release by neurotrophins: Implications fro activity dependent neurons.

1997 • 106 citations

A survey of furin substrate specificity using substrate phage display

1994 • 101 citations

Mechanisms of Intracellular Trafficking and Processing of Proproteins

1992 • 96 citations

The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells

1996 • 92 citations

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1996 • 91 citations

α1-Antitrypsin Portland Inhibits Processing of Precursors Mediated by Proprotein Convertases Primarily within the Constitutive Secretory Pathway

1997 • 88 citations

A Protease Processing Site Is Essential for Prorenin Sorting to the Regulated Secretory Pathway

1996 • 84 citations

Immunological relationships of NGF, BDNF, and NT-3: recognition and functional inhibition by antibodies to NGF

1993 • 54 citations

Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non‐endocrine cell line, COS‐7

1992 • 51 citations

Constitutive And Regulated Secretion Of Proteins

1987 • 39 citations

Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

1991 • 37 citations

Cell Type-Specific Sorting of Neuropeptides: A Mechanism to Modulate Peptide Composition of Large Dense-Core Vesicles

1996 • 35 citations

Membrane Traffic in Neurons and Peptide-secreting Cells

1983 • 34 citations

Expression of neurotrophin genes in human fibroblasts: Differential regulation of the brain‐derived neurotrophic factor gene

1994 • 34 citations

Cortical development: With an eye on neurotrophins

1996 • 23 citations

Sequence requirements for proteolytic cleavage of precursors with paired basic amino acids

1991 • 23 citations

Nerve growth factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. leprae infection and macrophage secretory products

1997 • 17 citations

Nerve growth factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. leprae infection and macrophage secretory products

1997 • 4 citations