Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes

2005 • 1,080 citations

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

2007 • 976 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes

2005 • 622 citations

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

2008 • 594 citations

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

2007 • 553 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

1993 • 431 citations

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

1993 • 347 citations

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

2000 • 344 citations

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

2005 • 339 citations

Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

2005 • 275 citations

Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus

2004 • 252 citations

In Vitro Characterization of Five Humanized OKT3 Effector Function Variant Antibodies

2000 • 219 citations

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

2009 • 207 citations

CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes

2007 • 181 citations

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)

2003 • 177 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

A humanized non–FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease

2002 • 173 citations

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses.

1988 • 172 citations

Prevention of Autoimmune Diabetes With Nonactivating Anti-CD3 Monoclonal Antibody

1992 • 132 citations

The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration

2004 • 132 citations

Evidence for In Vivo Primed and Expanded Autoreactive T Cells as a Specific Feature of Patients with Type 1 Diabetes

2007 • 126 citations

ANTI-CD3 F(abʼ)2 FRAGMENTS ARE IMMUNOSUPPRESSIVE IN VIVO WITHOUT EVOKING EITHER THE STRONG HUMORAL RESPONSE OR MORBIDITY ASSOCIATED WITH WHOLE mAb

1990 • 124 citations

HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes

2006 • 115 citations

Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes

2005 • 110 citations

Immediate Early Effector Functions of Virus-Specific CD8+CCR7+ Memory Cells in Humans Defined by HLA and CC Chemokine Ligand 19 Tetramers

2003 • 97 citations

Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells

2004 • 93 citations

The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

2008 • 88 citations

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

2006 • 86 citations

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

2005 • 78 citations

HLA class II tetramers: Tools for direct analysis of antigen-specific CD4+ T cells

2002 • 70 citations

Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes

2003 • 56 citations

Impaired CD4+ and CD8+ T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children

2008 • 32 citations

Cytotoxic T Cells to an Epitope in the Islet Autoantigen IA-2 Are Not Disease-Specific

2001 • 32 citations

Humanized, Nonmitogenic OKT3 Antibody, huOKT3γ(Ala-Ala): Initial Clinical Experience

1998 • 31 citations

Measurement of CD8⁺ T Cell Responses in Human Type 1 Diabetes

2008 • 24 citations

HLA Class I Epitope Discovery in Type 1 Diabetes

2006 • 23 citations

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL

2004 • 22 citations

Kinetic Evolution of a Diabetogenic CD8+ T Cell Response

2003 • 13 citations