HER2 overexpression and cancer targeting

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

1998 • 1,013 citations

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

1999 • 983 citations

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

1993 • 888 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1992 • 855 citations

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

1992 • 769 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

1997 • 719 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations

1996 • 455 citations

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

1997 • 454 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

1995 • 407 citations

HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway

2000 • 375 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase

1998 • 354 citations

The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

1997 • 344 citations

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

1992 • 338 citations

Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up.

1992 • 318 citations

Role of HER2 gene overexpression in breast carcinoma

2000 • 306 citations

Single-Chain Antibody-Mediated Intracellular Retention of ErbB-2 Impairs Neu Differentiation Factor and Epidermal Growth Factor Signaling

1995 • 300 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.

1999 • 293 citations

Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers.

1992 • 280 citations

Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.

1992 • 267 citations

Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene

1992 • 266 citations

Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.

1993 • 261 citations

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

1993 • 252 citations

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

1988 • 251 citations

Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease

1991 • 250 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.

1990 • 232 citations

HER‐2/ neu Signal Transduction in Human Breast and Ovarian Cancer

1997 • 227 citations

Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities.

1997 • 225 citations

Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.

1996 • 222 citations

c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties

1995 • 210 citations

An Intramembrane Modulator of the ErbB2 Receptor Tyrosine Kinase That Potentiates Neuregulin Signaling

1999 • 197 citations

Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotion

1995 • 194 citations

Emodin, a Protein Tyrosine Kinase Inhibitor from Polygonum cuspidatum

1992 • 180 citations

Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor.

1992 • 176 citations

Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations

1993 • 170 citations

Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.

1995 • 164 citations

The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

2000 • 164 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.

1999 • 158 citations

Trastuzumab in the Treatment of Metastatic Breast Cancer

2000 • 156 citations

Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.

1997 • 155 citations

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells

1994 • 153 citations

Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.

1999 • 150 citations

Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.

1990 • 140 citations

Nonviral vectors for gene therapy

1999 • 139 citations

Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

1995 • 137 citations

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines.

1993 • 133 citations

Amplification, overexpression, and rearrangement of the erbB-2 protooncogene in primary human stomach carcinomas.

1989 • 130 citations

Overexpression of the c‐erbB‐2/neu–encoded p185 protein in primary lung cancer

1992 • 129 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms.

1995 • 125 citations

Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol

1998 • 124 citations

Inhibition of Nuclear Factor-κB Activity Is Involved in E1A-mediated Sensitization of Radiation-induced Apoptosis

1997 • 123 citations

Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.

1990 • 119 citations

A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.

1996 • 117 citations

Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.

1996 • 113 citations

Antioncogenic effect of adenovirus E1A in human tumor cells.

1991 • 112 citations

Theetsmultigene family is conserved throughout the Metazoa

1993 • 108 citations

E1A Sensitizes Cells to Tumor Necrosis Factor-induced Apoptosis through Inhibition of IκB Kinases and Nuclear Factor κB Activities

1999 • 102 citations

Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.

1991 • 100 citations

Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.

1995 • 97 citations

Ligand and p185c-neu density govern receptorinteractions and tyrosine kinase activation.

1994 • 92 citations

Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells

1997 • 91 citations

Enhanced Chemoresistance by Elevation of p185neu Levels in HER-2/neu-Transfected Human Lung Cancer Cells

1995 • 89 citations

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

1991 • 87 citations

p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins.

1995 • 86 citations

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.

1992 • 85 citations

The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer

1997 • 82 citations

Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism.

1995 • 71 citations

HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model.

1995 • 70 citations

Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo

1998 • 70 citations

Calcium-Dependent Stimulation of Mitogen-Activated Protein Kinase Activity in A431 Cells by Low Doses of Ionizing Radiation

1998 • 69 citations

Evolution of the ets Gene Family

1993 • 63 citations

Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase.

1999 • 63 citations

Axl-Gas6 Interaction Counteracts E1A-Mediated Cell Growth Suppression and Proapoptotic Activity

1999 • 62 citations

Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.

1991 • 60 citations

The E1a Gene of Adenovirus Type 2 Reduces the Metastatic Potential of ras-Transformed Rat Embryo Cells

1988 • 57 citations

Mitosis-specific Negative Regulation of Epidermal Growth Factor Receptor, Triggered by a Decrease in Ligand Binding and Dimerization, Can Be Overcome by Overexpression of Receptor

1997 • 57 citations

Oncogene-lnitiated Aberrant Signaling Engenders the Metastatic Phenotype: Synergistic Transcription Factor Interactions are Targets for Cancer Therapy

1996 • 55 citations

Involvement of Co-activator p300 in the Transcriptional Regulation of the HER-2/neu Gene

1997 • 55 citations

Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

1989 • 52 citations

ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

1995 • 52 citations

Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras.

1988 • 45 citations

Safety study and characterization of E1A–liposome complex gene-delivery protocol in an ovarian cancer model

1998 • 43 citations

A Role for the ETS Domain Transcription Factor PEA3 in Myogenic Differentiation

1997 • 41 citations

Differentiation-stimulated Activity Binds an ETS-like, Essential Regulatory Element in the Human Promyelocytic defensin-1Promoter

1998 • 35 citations

Safety studies of the intraperitoneal injection of E1A–liposome complex in mice

1997 • 35 citations

Cloning and characterization of the mouse neu promoter.

1992 • 33 citations

Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A.

1993 • 33 citations

Association of the Ras to Mitogen-activated Protein Kinase Signal Transduction Pathway with Microfilaments

1999 • 29 citations

Adenovirus E1A-Mediated Negative Control of Genes Activated during F9 Differentiation

1989 • 26 citations

Identification and Characterization of a Novel Enhancer for the Rat neu Promoter

1991 • 25 citations

Cell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.

1995 • 23 citations

MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES

1994 • 19 citations

REGULATION OF HER2/NEU GENE-EXPRESSION (REVIEW)

1995 • 15 citations

Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome

1999 • 10 citations

Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185neu

1997 • 9 citations