The E1a Gene of Adenovirus Type 2 Reduces the Metastatic Potential of ras-Transformed Rat Embryo Cells

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

The roles of individual polyoma virus early proteins in oncogenic transformation

1982 • 366 citations

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

1983 • 353 citations

Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.

1981 • 304 citations

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture

1985 • 288 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element

1983 • 250 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.

1983 • 240 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.

1984 • 150 citations

Evolution of tumor cell heterogeneity during progressive growth of individual lung metastases.

1982 • 142 citations

Lytic and transforming functions of individual products of the adenovirus E1A gene

1986 • 136 citations

Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids

1982 • 118 citations

Tumor implantation and invasion at metastatic sites.

1983 • 115 citations

The E4 transcilpilonal unit of Ad2: far upstream sequences are required for its transactivation by E1A

1984 • 86 citations

Tumorigenicity of adenovirus-transformed cells: Region E1A of adenovirus 12 confers resistance to natural killer cells

1985 • 74 citations

Adenovirus: Transformation and oncogenicity

1984 • 58 citations

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.

1985 • 57 citations

Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.

1986 • 51 citations

Differential NK Cell and Macrophage Killing of Hamster Cells Infected with Nononcogenic or Oncogenic Adenovirus

1984 • 40 citations

Cancer cells, components of basement membranes, and proteolytic enzymes.

1985 • 35 citations

Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5

1984 • 29 citations

Different activities of the adenovirus types 5 and 12 E1A regions in transformation with the EJ Ha-ras oncogene

1986 • 28 citations