Identification and Characterization of a Novel Enhancer for the Rat neu Promoter

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Current protocols in molecular biology

1988 • 4,543 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

1988 • 321 citations

A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.

1989 • 314 citations

Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes

1987 • 312 citations

Compilation of transcription regulating proteins

1988 • 303 citations

Use of a protein-blotting procedure and a specific DNA probe to identify nuclear proteins that recognize the promoter region of the transferrin receptor gene.

1985 • 290 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.

1990 • 143 citations

Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester

1990 • 143 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.

1990 • 140 citations

Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.

1988 • 127 citations

Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.

1989 • 101 citations

Estrogen receptor selectively binds the "coding strand" of an estrogen responsive element.

1989 • 94 citations

Characterization of the promoter region of the human c-erbB-2 protooncogene.

1987 • 87 citations

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1984 • 84 citations

Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation.

1987 • 77 citations

Transformation of NIH 3T3 Cells by Overexpression of the Normal Coding Sequence of the Rat neu Gene

1990 • 75 citations

DNA denatures upon drying after ethanol precipitation

1987 • 59 citations

c-myc reverses neu-induced transformed morphology by transcriptional repression.

1991 • 59 citations

DNase I Footprinting as an Assay for Mammalian Gene Regulatory Proteins

1987 • 53 citations

Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

1989 • 52 citations

Multiple cis- and trans-acting elements involved in regulation of the neu gene.

1990 • 51 citations

Structure and inducible regulation of the human c-erb B2/neu promoter.

1990 • 51 citations

Direct sequencing analysis of transmembrane region of human neu gene by polymerase chain reaction

1990 • 28 citations

Characterization of the promoter region of the human c-erb B-2 proto-oncogene

1987 • 25 citations