Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Breast Tumor Cell Lines From Pleural Effusions2

1974 • 973 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 • 606 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

1987 • 315 citations

A new in vitro assay for quantitating tumor cell invasion.

1989 • 297 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.

1996 • 222 citations

Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis.

1991 • 166 citations

Metastatic tumor cell interactions with endothelium, basement membrane and tissue

1989 • 157 citations

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.

1990 • 143 citations

Expression of gelatinase A and TIMP-2 mRNAs in desmoplastic fibroblasts in both mammary carcinomas and basal cell carcinomas of the skin.

1993 • 136 citations

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.

1992 • 85 citations

A study on fibroblast chemotaxis using fibronectin and conditioned medium as chemoattractants.

1983 • 62 citations

Stimulation of angiogenesis as an explanation of matrigel‐enhanced tumorigenicity

1994 • 48 citations

Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu.

1995 • 32 citations

Low Metastatic Potential of Clone From Murine Colon Adenocarcinoma 26 Increased by Transfection of Activated c-erbB-2 Gene

1990 • 31 citations

Direct sequencing analysis of transmembrane region of human neu gene by polymerase chain reaction

1990 • 28 citations