Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

1988 • 541 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.

1994 • 346 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

Regulation of 2‐acetylaminofluorene‐and 3‐methylcholanthrene‐mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1991 • 125 citations

Pathology of cytoskeleton of liver cells: Demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes

1981 • 124 citations

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

1991 • 104 citations

Biochemical and immunocytochemical analysis of the intermediate filament cytoskeleton in human hepatocellular carcinomas and in hepatic neoplastic nodules of mice.

1982 • 103 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Hepatocellar hyalin (Mallory bodies) in long term griseofulvin-treated mice: a new experimental model for the study of hyalin formation.

1975 • 98 citations

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas.

1990 • 85 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

Mallory bodies in experimental animals and man.

1979 • 72 citations

Multidrug resistance genes, p-glycoprotein and the liver

1990 • 57 citations

Experimental Production of Mallory Bodies in Mice by Diet Containing 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine

1982 • 55 citations

Experimental induction of hepatocellular hyalin (Mallory bodies) in mice by griseofulvin treatment. 1. Light microscopic observation.

1976 • 47 citations

Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice.

1992 • 39 citations

High molecular weight component of Mallory bodies detected by a monoclonal antibody.

1990 • 39 citations

Hepatocellular cytokeratins as substrates of transglutaminases.

1989 • 38 citations

The mouse multidrug resistance gene family: structural and functional analysis.

1993 • 36 citations

Fate of Mallory body-containing hepatocytes: Disappearance of Mallory bodies and restoration of the hepatocytic intermediate filament cytoskeleton after drug withdrawal in the griseofulvin-treated mouse

1990 • 36 citations

Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody.

1992 • 25 citations

Murinemdr-1, mdr-2,andmdr-3Gene Expression: No Coinduction with theCypla-1andNmo-1Genes in Liver by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

1991 • 22 citations

Changes of cytokeratin filament organization in human and murine Mallory body‐containing livers as revealed by a panel of monoclonal antibodies

1991 • 16 citations

Pathology of the cytoskeleton of hepatocytes.

1986 • 15 citations

Ubiquitin and the Lysosomal System: Molecular Pathological and Experimental Findings

1991 • 11 citations

Expression of multidrug‐resistance (P‐glycoprotein) genes in liver cancers: A molecular example of the convergence theory of hepatocarcinogenesis?

1993 • 11 citations

Enzyme‐histochemical studies of griseofulvin‐intoxicated mouse livers

1991 • 7 citations