Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

[10] Gangliosides: Structure, isolation, and analysis

1982 • 705 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

ANIMAL GLYCOSPHINGOLIPIDS AS MEMBRANE ATTACHMENT SITES FOR BACTERIA

1989 • 686 citations

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1988 • 315 citations

Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium.

1979 • 306 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase

1987 • 254 citations

Intracellular transport and metabolism of sphingomyelin

1991 • 236 citations

Gangliosides shed by tumor cells enhance tumor formation in mice.

1987 • 144 citations

Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells

1987 • 138 citations

Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.

1990 • 99 citations

Sulfated glycolipids and cell adhesion

1988 • 99 citations

Effects of D‐threo‐PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells

1989 • 99 citations

Biochemistry of Organ Glycolipids

1964 • 96 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells

1990 • 86 citations

Antitumor activity via inhibition of glycosphingolipid biosynthesis

1987 • 74 citations

Use of diacylglycerol kinase to quantitate picomole levels of 1,2-diacylglycerol

1979 • 67 citations

Biosynthesis of sphingomyelin from Eryrtro-ceramides and phosphatidylcholine by a microsomal cholinephosphotransferase

1981 • 58 citations

Preparative isolation of cerebrosides (galactosyl and glucosyl ceramide)

1976 • 54 citations

Glucosphingolipids as sites of action in the chemotherapy of cancer

1988 • 49 citations

Glucosphingolipid dependence of hormone-stimulated inositol trisphosphate formation.

1990 • 49 citations

Stimulation of liver growth and DNA synthesis by glucosylceramide

1988 • 44 citations

Growth effects of lithium chloride in BALB/c 3T3 fibroblasts and madin-darby canine kidney epithelial cells

1981 • 43 citations

Gaucher's disease and chronic lymphocytic leukemia. Possible pathogenetic link between Gaucher's disease and b-cell proliferations?

1984 • 43 citations

Synthesis of diacylglycerol de novo is responsible for permanent activation and down-regulation of protein kinase C in transformed cells

1989 • 39 citations

Improved synthesis of conduritol B epoxide

1985 • 29 citations

Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor

1991 • 28 citations

Enzymic effects of β-glucosidase destruction in mice changes in glucuronidase levels

1979 • 23 citations

Use of PDMP for the Study of Glycosphingolipid Functions.

1991 • 18 citations

The effects of N-hexyl-O-glucosyl sphingosine on normal cultured human fibroblasts: a chemical model for Gaucher's disease

1976 • 11 citations