Involvement of nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Analysis of reduced forms of biopterin in biological tissues and fluids

1980 • 713 citations

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction

1993 • 569 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

1994 • 199 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

1992 • 162 citations

Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity.

1995 • 153 citations

Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma

1986 • 151 citations

An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures

1990 • 128 citations

Nitric Oxide Acts in Conjunction with Proinflammatory Cytokines to Promote Cell Death in Osteoblasts

1997 • 118 citations

Skeletal Tissue Response to Cytokines

1990 • 116 citations

The effects of recombinant human interleukin-1β on cellular proliferation and the production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phosphatase by osteoblast-like cells derived from human bone

1990 • 111 citations

Effects of interleukin-1? and tumor necrosis factor-? on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro

1992 • 107 citations

Cytokines Induce Nitric Oxide Production in Mouse Osteoblasts

1994 • 105 citations

Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264).

1993 • 95 citations

Skeletal tissue response to cytokines.

1990 • 88 citations

Induction of apoptosis in murine clonal osteoblasts expressed by human T-cell leukemia virus type I tax by NF-κPB and TNF-α

1996 • 74 citations

Impact of tumour necrosis factor-α and interferon-γ on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages

1991 • 48 citations

Tetrahydrobiopterin as a Mediator of PC12 Cell Prolifeiation Induced by EGF and NGF

1997 • 40 citations

Tetrahydrobiopterin biosynthesis in C6 glioma cells: induction of GTP cyclohydrolase I gene expression by lipopolysaccharide and cytokine treatment

1996 • 37 citations

Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines

1998 • 37 citations

Formation and mineralization of extracellular matrix secreted by an immortal human osteoblastic cell line: Modulation by tumor necrosis factor-alpha

1994 • 35 citations

Mitogenic effects of tetrahydrobiopterin in PC12 cells.

1996 • 30 citations

Modulation of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) induced HL-60 cell death by tetrahydrobiopterin.

1997 • 13 citations