Formation and Function of Eicosanoids in the Central Nervous System

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Handbook of Experimental Pharmacology

1968 • 789 citations

Advances in prostaglandin, thromboxane, and leukotriene research

1985 • 759 citations

Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Other Derivatives of Carbon‐20 Unsaturated Fatty Acids

1982 • 580 citations

Functional receptors for neurotransmitters on astroglial cells

1987 • 436 citations

Accumulation of Cyclooxygenase Products of Arachidonic Acid Metabolism in Gerbil Brain During Reperfusion After Bilateral Common Carotid Artery Occlusion

1980 • 367 citations

Synthesis of Compounds with Properties of Leukotrienes C ₄ and D ₄ in Gerbil Brains After Ischemia and Reperfusion

1984 • 350 citations

Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain

1977 • 232 citations

Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.

1988 • 225 citations

Leukotrienes in the rat central nervous system.

1984 • 162 citations

Prostaglandin D2, a cerebral sleep-inducing substance in rats.

1983 • 154 citations

Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation

1987 • 144 citations

Prostaglandin profiles in nervous tissue and blood vessels of the brain of various animals

1980 • 116 citations

Identification of the neuroeffector transmitter in jejunal branches of the rabbit mesenteric artery

1987 • 115 citations

Identification of a smooth muscle-stimulating factor in bovine brain Prostaglandins and related factors 25

1964 • 113 citations

Comparison of prostanoid forming capacity of neuronal and astroglial cells in primary cultures

1985 • 109 citations

The Mongolian gerbil (Meriones unguiculatus) as a model for the study of the epilepsies: EEG records of seizures

1975 • 108 citations

Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates

1979 • 106 citations

Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain

1982 • 95 citations

Leukotrienes in health and disease

1987 • 94 citations

Effect of Bicuculline‐Induced Status Epilepticus on Prostaglandins and Hydroxyeicosatetraenoic Acids in Rat Brain Subcellular Fractions

1987 • 80 citations

PGF2α, thromboxane B2 and hete levels in gerbil brain cortex after ligation of common carotid arteries and decapitation

1979 • 80 citations

Formation of leukotriene C4-like material by rat brain tissue

1984 • 79 citations

Are cerebral prostanoids of astroglial origin? Studies on the prostanoid forming system in developing rat brain and primary cultures of rat astrocytes

1987 • 79 citations

Lowering of the convulsive threshold by non-steroidal anti-inflammatory drugs

1981 • 71 citations

Eicosanoid synthesis and release from primary cultures of rat central nervous system astrocytes and meningeal cells

1985 • 69 citations

Increased prostaglandin formation in rat brain following systemic application of kainic acid

1987 • 66 citations

Lipoxygenase Metabolism of Arachidonic Acid in Brain

1985 • 65 citations

Regional distribution of leukotriene and mono‐hydroxyeicosatetraenoic acid production in the rat brain Highest leukotriene C₄ formation in the hypothalamus

1987 • 59 citations

Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2?

1983 • 59 citations

Regional distribution of arachidonic acid metabolites in rat brain following convulsive stimuli

1981 • 57 citations

Leukotriene production by cultured astroglial cells

1987 • 56 citations

Electroencephalographic correlates of the audiogenic seizure response of inbred mice

1976 • 55 citations

Electroconvulsive shock raises prostaglandins F in rat cerebral cortex

1975 • 55 citations

Phorbol diester TPA elicits prostaglandin E release from cultured rat astrocytes

1987 • 54 citations

Comparison of the prostanoid synthesizing capacity in homogenates from primary neuronal and astroglial cell cultures

1984 • 53 citations

Phorbol ester stimulation of prostanoid synthesis by cultured astrocytes

1987 • 51 citations

Anticonvulsive effects of endogenous prostaglandins formed in brain of spontaneously convulsing gerbils

1984 • 49 citations

Relation between prostaglandin E2, F2α, and cyclic nucleotides levels in rat brain and induction of convilsions

1977 • 48 citations

Enzymic Synthesis of Leukotriene B₄ in Guinea Pig Brain

1987 • 47 citations

Adrenergic and cholinergic stimulation of arachidonate and phosphatidate metabolism in cultured astroglial cells

1986 • 39 citations

Prostanoid profile in specific brain areas, pituitary and pineal gland of the male rat. Influence of experimental conditions

1983 • 37 citations

[74] Use of microwave techniques to inactivate brain enzymes rapidly

1982 • 29 citations

Increase in brain prostaglandins during convulsions is due to increased neuronal activity and not to hypoxia.

1983 • 29 citations

Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils

1984 • 26 citations

The formation and regional distribution of prostaglandins D2 and F2α in the brain of spontaneously convulsing gerbils

1985 • 25 citations

Differential effects of probenecid on the levels of endogenous PGF2α and TXB2 in brain cortex

1979 • 24 citations

Formation of sulphidopeptide-leukotrienes in brain tissue of spontaneously convulsing gerbils

1987 • 23 citations

Characterization of Seizure‐Induced Cysteinyl‐Leukotriene Formation in Brain Tissue of Convulsion‐Prone Gerbils

1988 • 23 citations

Inositol phospholipids are probably not the source of arachidonic acid for eicosanoid synthesis in astrocytes

1987 • 23 citations

Changes in cyclooxygenase activity and prostaglandin profiles during monoamine metabolism in rat brain homogenates

1984 • 21 citations

C-6-Sulfidopeptide leukotrienes are unlikely to be involved in the endothelium dependent relaxation of rabbit aorta by acetylcholine

1984 • 19 citations

Prostanoid formation in primary astroglial cell cultures: Ca2+-dependency and stimulation by A 23187, melittin and phospholipases A2 and C

1987 • 17 citations

Studies on prostaglandin F2α formation caused by pentametylenetetrazol-induced convulsions in rat brain

1981 • 17 citations

Differential prostaglandin formation induced by convulsion in the brain of mice susceptible (DBA/2J) and resistant (CFLP) to acoustic stimulation

1990 • 11 citations

Involvement of protein kinase C in prostaglandin D2 synthesis by cultured astrocytes

1988 • 11 citations