Ascorbate Is the Primary Reductant of the Phenoxyl Radical of Etoposide in the Presence of Thiols both in Cell Homogenates and in Model Systems

Tissue sulfhydryl groups

1959 • 25,130 citations

Biochemistry of metallothionein

1988 • 1,222 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

1990 • 461 citations

Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase

1992 • 363 citations

Ascorbate free radical as a marker of oxidative stress: An EPR study

1993 • 360 citations

Recycling of vitamin E in human low density lipoproteins.

1992 • 329 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Metallothionein protects DNA from oxidative damage

1993 • 254 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

1990 • 194 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Potential role of free radicals in benzene-induced myelotoxicity and leukemia

1991 • 139 citations

Differences between male and female rats in the regulation of hepatic glycogenolysis. The relative role of calcium and cAMP in phosphorylase activation by catecholamines.

1982 • 120 citations

Oxygen dependence of oxidative stress

1990 • 99 citations

Peroxidase-catalyzed Oxidation of Eugenol: Formation of a Cytotoxic Metabolite(s)

1989 • 96 citations

Generation and recycling of radicals from phenolic antioxidants

1990 • 92 citations

Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules.

1987 • 74 citations

Radioprotection of Hematopoietic Tissues in Mice by Lipoic Acid

1992 • 73 citations

Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.

1991 • 64 citations

Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26)

1986 • 63 citations

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR study

1989 • 63 citations

A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program

1990 • 60 citations

Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds

1989 • 59 citations

Oxygen dependence of glutathione synthesis in hepatocytes

1989 • 47 citations

Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): Implications for mode of action

1985 • 35 citations

Genotoxicity of Phenolic Antioxidants

1993 • 33 citations

Immunohistochemical localization of metallothionein in the eye of rats

1991 • 33 citations

Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack

1993 • 32 citations

Interactions of the antitumor drug, etoposide, with reduced thiols in vitro and in vivo

1987 • 30 citations

Structure-activity relationships defining the cytotoxicity of catechol analogues against human malignant melanoma.

1988 • 23 citations

Photoreactions of thymine and thymidine with N-acetyltyrosine

1992 • 22 citations

Coppier ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide

1990 • 18 citations

Tyrosinase-Induced Free Radical Formation From VP-16,213: Relationship To Cytotoxicity

1990 • 17 citations

Pineal and retinal protein kinase C isoenzymes: Cooperative activation by calcium and zinc metallothionein

1992 • 16 citations

One-Electron Oxidation of Trolox C (a Vitamin E Analogue) by Peroxidases

1990 • 14 citations

Tyrosinase-Induced Phenoxyl Radicals of Etoposide (VP-16): Interaction with Reductants in Model Systems, K562 Leukemic Cell and Nuclear Homogenates

1993 • 12 citations

Forestomach neoplasms in Fischer F344/N rats and B6C3F1 mice exposed to diglycidyl resorcinol ether—an epoxy resin

1990 • 5 citations

Effects of Oxygen Radical Scavengers on the Inactivation of SS ΦX174 DNA by the Semi-Quinone Free Radical of the Antitumor Agent Etoposide

1990 • 4 citations