Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

2001 • 3,785 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system

2000 • 1,053 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

CREB: A Major Mediator of Neuronal Neurotrophin Responses

1997 • 936 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

2001 • 882 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function

1995 • 812 citations

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

1999 • 797 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

The neurotrophin hypothesis for synaptic plasticity

2000 • 729 citations

Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis.

2002 • 720 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation ofArcSynthesis

2002 • 638 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Making New Connections

1999 • 601 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Expression of Constitutively Active CREB Protein Facilitates the Late Phase of Long-Term Potentiation by Enhancing Synaptic Capture

2002 • 571 citations

Neurotrophin-evoked rapid excitation through TrkB receptors

1999 • 540 citations

Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses

2001 • 508 citations

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

1997 • 482 citations

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

2002 • 468 citations

Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice

1999 • 463 citations

Abnormal Cerebellar Development and Foliation in BDNF−/− Mice Reveals a Role for Neurotrophins in CNS Patterning

1997 • 432 citations

BDNF, and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones

1994 • 402 citations

Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2

1995 • 402 citations

The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB

2000 • 399 citations

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

1996 • 350 citations

Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

2001 • 333 citations

Enhancement of Neurotransmitter Release Induced by Brain-Derived Neurotrophic Factor in Cultured Hippocampal Neurons

1998 • 317 citations

Neurotrophin regulation of synaptic transmission

1999 • 315 citations

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

1998 • 302 citations

An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory

2001 • 285 citations

A Phospho-Switch Controls the Dynamic Association of Synapsins with Synaptic Vesicles

1999 • 269 citations

A role for BDNF in the late-phase of hippocampal long-term potentiation

1998 • 260 citations

CaM-kinases: modulators of synaptic plasticity

2000 • 232 citations

TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.

1996 • 231 citations

Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

1996 • 221 citations

Deficits in Memory Tasks of Mice with CREB Mutations Depend on Gene Dosage

1998 • 214 citations

Ulysses Solar Wind Plasma Observations at High Southerly Latitudes

1995 • 207 citations

Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

1998 • 199 citations

The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture

1987 • 195 citations

Reversible inhibition of

1996 • 121 citations

Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways

2001 • 101 citations

Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes

1989 • 67 citations

Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation

2000 • 38 citations

Postsynaptic Elevation of Calcium Induces Persistent Depression of Developing Neuromuscular Synapses

1996 • 37 citations

Activation of Dynamin I Gene Expression by Sp1 and Sp3 Is Required for Neuronal Differentiation of N1E-115 Cells

2002 • 34 citations

A 27 kd protein of E. coli promotes antitermination of replication in vitro at a sequence-specific replication terminus

1993 • 20 citations