Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin

The glamour and gloom of glycogen synthase kinase-3

2004 • 1,490 citations

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

2009 • 1,345 citations

An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior

2005 • 939 citations

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

2004 • 770 citations

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

2000 • 525 citations

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

2008 • 513 citations

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

1998 • 467 citations

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

2008 • 426 citations

Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

2008 • 407 citations

Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

2003 • 362 citations

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

2008 • 346 citations

WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells

2005 • 339 citations

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

2003 • 272 citations

Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretion

2004 • 257 citations

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

2006 • 237 citations

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3

2004 • 234 citations

The Antiapoptotic Actions of Mood Stabilizers: Molecular Mechanisms and Therapeutic Potentials

2005 • 198 citations

Psychiatric findings in Wolfram syndrome homozygotes

1990 • 182 citations

Sodium–glucose co‐transporter‐2 inhibitors: an emerging new class of oral antidiabetic drug

2008 • 170 citations

Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder

2006 • 149 citations

Targets for antiepileptic drugs in the synapse.

2007 • 131 citations

A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3

2002 • 130 citations

Streptozotocin-Induced Diabetes in Large Animals (Pigs/Primates): Role of GLUT2 Transporter and β-cell Plasticity

2006 • 115 citations

Molecular neurobiology of bipolar disorder: a disease of ‘mood-stabilizing neurons’?

2008 • 103 citations

Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice

2008 • 88 citations

Psychiatric disorders in 36 families with Wolfram syndrome

1991 • 87 citations

Valproate-Induced Insulin Resistance and Obesity in Children

2009 • 81 citations

Impaired Endoplasmic Reticulum Stress Response in B-Lymphoblasts From Patients With Bipolar-I Disorder

2007 • 81 citations

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activation

2005 • 79 citations

Support for the possible locus on chromosome 4p16 for bipolar affective disorder

1998 • 78 citations

Wfs1-deficient mice display impaired behavioural adaptation in stressful environment

2008 • 75 citations

XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

2006 • 73 citations

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

2009 • 59 citations

A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: Possible clinical significance

1985 • 58 citations

Psychiatric disorders and mutations at the Wolfram syndrome locus

2000 • 54 citations

Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway

2009 • 51 citations

Association of the XBP1−116C/G polymorphism with schizophrenia in the Japanese population

2004 • 45 citations

Valproate causes metabolic disturbance in normal man.

1986 • 44 citations

Mutation screening of the Wolfram syndrome gene in psychiatric patients

2000 • 42 citations

WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder

2000 • 38 citations

Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder

2000 • 38 citations

Sequence variation in DOCK9 and heterogeneity in bipolar disorder

2007 • 38 citations

Molecular and cellular mechanisms underlying mood stabilization in bipolar disorder: implications for the development of improved therapeutics

2002 • 36 citations

Is there a relationship between Wolfram syndrome carrier status and suicide?

2002 • 33 citations

Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands

2003 • 32 citations

Impaired striatal dopamine output of homozygous Wfs1 mutant mice in response to [K+] challenge

2010 • 16 citations

The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders

2003 • 15 citations

The effect of valproate on blood metabolite concentrations in spontaneously diabetic, ketoacidotic, BB/E Wistar rats.

1985 • 11 citations

Inhibition of glucose-induced insulin secretion by a peripheral-type benzodiazepine receptor ligand (PK 11195)

2000 • 6 citations