Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

Phlorizin: a review

2004 • 855 citations

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

1987 • 792 citations

Active sugar transport in health and disease

2007 • 610 citations

The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

1994 • 598 citations

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

2008 • 574 citations

Brenner and Rector's the Kidney

2003 • 565 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

Molecular physiology of sodium-glucose cotransporters.

1994 • 416 citations

Glomerular Hyperfiltration in Experimental Diabetes Mellitus

1999 • 338 citations

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

1987 • 335 citations

Molecular Analysis of the SGLT2 Gene in Patients with Renal Glucosuria

2003 • 297 citations

Sergliflozin, a Novel Selective Inhibitor of Low-Affinity Sodium Glucose Cotransporter (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose Reabsorption and Modulates Plasma Glucose Level

2006 • 263 citations

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

1999 • 245 citations

Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)

2002 • 212 citations

Molecular Characteristics of Na+-coupled Glucose Transporters in Adult and Embryonic Rat Kidney

1995 • 197 citations

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

2001 • 187 citations

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

1991 • 172 citations

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

1995 • 168 citations

Bioavailability of Phloretin and Phloridzin in Rats

2001 • 167 citations

Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter

1992 • 160 citations

In vivo insulin sensitivity in the rat determined by euglycemic clamp

1983 • 155 citations

Improved diabetic syndrome in C57BL/KsJ‐db/db mice by oral administration of the Na⁺‐glucose cotransporter inhibitor T‐1095

2001 • 153 citations

Phlorizin hydrolase: A β-glucosidase of hamster intestinal brush border membrane

1969 • 103 citations

Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats

2000 • 73 citations

Effects of hyperglycemia on glucose transporters of the muscle

1992 • 68 citations

Antidiabetic effect of T-1095, an inhibitor of Na+-glucose cotransporter, in neonatally streptozotocin-treated rats

2000 • 58 citations

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions

2006 • 56 citations

Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats.

1996 • 46 citations

Glucose Rapidly Decreases Plasma Membrane GLUT4 Content in Rat Skeletal Muscle

1999 • 32 citations

Antihyperglycemic Effect of T-1095 via Inhibition of Renal Na+-Glucose Cotransporters in Streptozotocin-Induced Diabetic Rats.

2000 • 30 citations