ICAM-1 co-stimulates target cells to facilitate antigen presentation

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

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The State of Lipid Rafts: From Model Membranes to Cells

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The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

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The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

2000 • 327 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

2000 • 296 citations

Characterization of a Nonclathrin Endocytic Pathway: Membrane Cargo and Lipid Requirements

2004 • 294 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

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ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration

2004 • 236 citations

The nature of molecular recognition by T cells

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Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes

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Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

1995 • 210 citations

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

1998 • 201 citations

CD28/CTLA-4 and CD80/CD86 families

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The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.

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Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts

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Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

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Intracellular Domain of Brain Endothelial Intercellular Adhesion Molecule-1 Is Essential for T Lymphocyte-Mediated Signaling and Migration

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MHC Class II-Peptide Complexes and APC Lipid Rafts Accumulate at the Immunological Synapse

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Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism.

1999 • 134 citations

Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

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Structural mechanisms of costimulation

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Cytotoxic T lymphocytes form an antigen-independent ring junction

2004 • 120 citations

Structural Basis for Dimerization of ICAM-1 on the Cell Surface

2004 • 104 citations

Ligation of ICAM-1 on Endothelial Cells Leads to Expression of VCAM-1 Via a Nuclear Factor-κB-Independent Mechanism

1999 • 103 citations

E‐selectin and ICAM‐1 are incorporated into detergent‐insoluble membrane domains following clustering in endothelial cells

2002 • 80 citations

Activation of SRC Tyrosine Kinases in Response to ICAM-1 Ligation in Pulmonary Microvascular Endothelial Cells

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Lateral organization of the ICAM‐1 molecule at the surface of human lymphoblasts: A possible model for its co‐distribution with the IL‐2 receptor, class I and class II HLA molecules

1994 • 75 citations

Cross-linking of Intercellular Adhesion Molecule-1 Induces Interleukin-8 and RANTES Production through the Activation of MAP Kinases in Human Vascular Endothelial Cells

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Clustering of Peptide-Loaded MHC Class I Molecules for Endoplasmic Reticulum Export Imaged by Fluorescence Resonance Energy Transfer

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Formation of a central supramolecular activation cluster is not required for activation of naive CD8 ⁺ T cells

2004 • 68 citations

Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells

2000 • 66 citations

Src Homology Domain 2-containing Tyrosine Phosphatase 2 Associates with Intercellular Adhesion Molecule 1 to Regulate Cell Survival

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Membrane domains and the immunological synapse: keeping T cells resting and ready

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Function by association? MHC antigens and membrane receptor complexes

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CD54/intercellular adhesion molecule 1 and major histocompatibility complex II signaling induces B cells to express interleukin 2 receptors and complements help provided through CD40 ligation.

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Membrane domains and the immunological synapse: keeping T cells resting and ready

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T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2

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The Role of Intercellular Adhesion Molecule-1/LFA-1 Interactions in the Generation of Tumor-Specific CD8+ T Cell Responses

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INF-γ Rearranges Membrane Topography of MHC-I and ICAM-1 in Colon Carcinoma Cells

2002 • 45 citations

Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy

1993 • 45 citations

The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death

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An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal.

1990 • 42 citations

Cross-Linking of Brain Endothelial Intercellular Adhesion Molecule (ICAM)-1 Induces Association of ICAM-1 With Detergent-Insoluble Cytoskeletal Fraction

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MHC Class II Molecules Traffic into Lipid Rafts during Intracellular Transport

2004 • 37 citations

ICAM-1 Contributes to but Is Not Essential for Tumor Antigen Cross-Priming and CD8+ T Cell-Mediated Tumor Rejection In Vivo

2005 • 33 citations

Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction.

1994 • 32 citations

Major histocompatibility complex class I–intercellular adhesion molecule‐1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes

2004 • 31 citations

Membrane topography of HLA I, HLA II, and ICAM-1 is affected by IFN-γ in lipid rafts of uveal melanomas

2004 • 25 citations

Cooperative Disengagement of Fas and Intercellular Adhesion Molecule-1 Function in Neoplastic Cells Confers Enhanced Colonization Efficiency

2005 • 22 citations