Genetic basis for a mouse model of down syndrome

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1967 • 1,210 citations

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

1981 • 836 citations

Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster

1983 • 626 citations

Lengths of chromosomal segments conserved since divergence of man and mouse.

1984 • 599 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

Genetic variants and strains of the Laboratory mouse

1996 • 500 citations

Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes

1982 • 292 citations

THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21

1973 • 291 citations

Population Cytogenetics: Studies in Humans

1978 • 279 citations

High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization.

1983 • 274 citations

The neurobiologie consequences of down syndrome

1986 • 249 citations

Enzyme Replacement Therapy for Adenosine Deaminase Deficiency and Severe Combined Immunodeficiency

1976 • 249 citations

A Correlation of Cytological and Genetical Crossing-Over in Zea Mays

1931 • 249 citations

Assignment of the genes for human λ immunoglobulin chains to chromosome 22

1981 • 239 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA.

1983 • 193 citations

Down's syndrome and acute leukemia: Myeloblastic or lymphoblastic?

1972 • 185 citations

Interferon effects on microfilament organization cellular fibronectin distribution, and cell motility in human fibroblasts

1980 • 178 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

ADENOSINE INHIBITION OF γ‐AMINOBUTYRIC ACID RELEASE FROM SLICES OF RAT CEREBRAL CORTEX

1980 • 163 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Construction and characterization of genomic libraries from specific human chromosomes.

1982 • 142 citations

Nucleotide sequence of a cDNA clone encoding mouse protamine 1

1985 • 133 citations

Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies

1982 • 129 citations

Interferon effects on the growth and division of human fibroblasts

1979 • 123 citations

Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.

1981 • 121 citations

Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes.

1980 • 121 citations

Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans.

1986 • 114 citations

Localization of the Gene AVG for the Antiviral Expression of Immune and Classical Interferon to the Distal Portion of the Long Arm of Chromosome 21

1976 • 110 citations

Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16.

1980 • 108 citations

Cystathionine beta synthase: Gene dosage effect in trisomy 21

1985 • 101 citations

Trisomy 21 (Down Syndrome) Research Perspectives

1981 • 101 citations

Assignment of the gene for cytoplasmic superoxide dismutase ( Sod-1 ) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse

1979 • 99 citations

Mouse trisomy 16 as an animal model of human trisomy 21 (Down syndrome): Production of viable trisomy 16 ↔ diploid mouse chimeras

1984 • 97 citations

Autosomal aneuploidy in mice: Generation and developmental consequences

1986 • 90 citations

Demonstration, by somatic cell genetics, of coordinate regulation of genes for two enzymes of purine synthesis assigned to human chromosome 21.

1981 • 86 citations

Location of genes coding for 18S and 28S ribosomal RNA within the genome of Mus musculus

1975 • 86 citations

The Dementia of Down's Syndrome and its Relevance to Aetiological Studies of Alzheimer's Disease

1982 • 85 citations

Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble).

1977 • 83 citations

Genetic structure of avian myeloblastosis virus, released from transformed myeloblasts as a defective virus particle

1980 • 82 citations

Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse.

1980 • 81 citations

An explanation of fine structure map expansion in terms of excision repair

1970 • 74 citations

Comparative Gene Mapping of Human Chromosome 21 and Mouse Chromosome 16a

1985 • 74 citations

Changes in fatty acyl chains of phospholipids induced by interferon in mouse sarcoma S-180 cells

1981 • 72 citations

Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.

1980 • 71 citations

Assignment of a type I collagen structural gene to human chromosome 7

1978 • 66 citations

Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16

1984 • 60 citations

Serum Uric Acid in Mongolism

1962 • 59 citations

T-lymphocyte function and sensitivity to interferon in trisomy 21

1980 • 58 citations

Alzheimer's disease, Down's syndrome, and aging.

1982 • 58 citations

Assignment of the Murine Interferon Sensitivity and Cytoplasmic Superoxide Dismutase Genes to Chromosome 16

1980 • 58 citations

Mapping of haploid expressed genes: Genes for both mouse protamines are located on chromosome 16

1986 • 57 citations

Down syndrome: Gene dosage at the transcriptional level in skin fibroblasts

1979 • 57 citations

Genetics of the connective tissue proteins: Assignment of the gene for human type I procollagen to chromosome 17 by analysis of cell hybrids and microcell hybrids

1977 • 56 citations

Experimental Genetics and Human Evolution

1966 • 56 citations

Developmental and other pathologic changes in syndromes caused by chromosome abnormalities.

1982 • 50 citations

Neurochemical Changes in Murine Trisomy 16: Delay in Cholinergic and Catecholaminergic Systems

1984 • 47 citations

Platelet-Derived Growth Factor (PDGF) Inhibits Antiviral and Anticellular Action of Interferon in Synchronized Mouse or Human Cells

1980 • 47 citations

A case of 21q-syndrome with normal SOD-1 activity

1979 • 47 citations

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Characterization of Chinese hamster cell mutants defective in phosphoribosylpyrophosphate amidotransferase and phosphoribosylglycinamide synthetase and an examination of alternatives to the first step of purine biosynthesis

1977 • 46 citations

Alzheimer's Disease, Down's Syndrome, and Aging: The Genetic Approach

1982 • 44 citations

Trisomy 21 (Down syndrome) : research perspectives

1981 • 43 citations

Moderate Down's syndrome in three siblings having partial trisomy 21q22.2?qter and therefore no SOD-1 excess

1982 • 43 citations

Two genetically transmitted BALB/c mouse mammary tumor virus genomes located on chromosomes 12 and 16

1984 • 42 citations

The effect of trisomy 21 on the patterns of polypeptide synthesis in human fibroblasts.

1979 • 40 citations

Establishment of the interferon-mediated antiviral state: possible role of superoxide dismutase.

1981 • 38 citations

Interferon-Resistant Cell Line Lacks Fatty Acid Cyclooxygenase Activity

1981 • 38 citations

Subregional Localization of the Gene(s) Governing the Human Interferon Induced Antiviral State in Man

1976 • 37 citations

Fatty acid composition of lipids of human brain myelin and synaptosomes: Changes in phenylketonuria and down's syndrome

1979 • 36 citations

Assignment of human phosphoribosylglycinamide synthetase locus to region 21q221

1984 • 35 citations

Trisomy 21: Mechanisms and Models*

1982 • 32 citations

Mouse chimeras composed of trisomy 16 and normal (2n) cells: Preliminary studies

1986 • 32 citations

Analysis of protein patterns in two-dimensional gels of cultured human cells with trisomy 21.

1982 • 30 citations

Fatty Acid Composition of Lipids in Cerebral Myelin and Synaptosomes in Phenylketonuria and Down Syndrome

1977 • 29 citations

Analysis of protein patterns in two-dimensional gels of cultured human cells with trisomy 21.

1982 • 27 citations

Protein Variations Associated with Down's Syndrome, Chromosome 21, and Alzheimer's Disease*

1982 • 25 citations

Comparative gene mapping: murine lambda light chain genes are located in region cen→B5 of mouse chromosome 16 not homolous to human chromosome 21

1982 • 23 citations

Molecular structure of the number 21 chromosome and Down syndrome.

1985 • 16 citations

ASSIGNMENT OF THE HUMAN ALPHA-CRYSTALLIN GENE (CRYA1) TO CHROMOSOME-21

1985 • 16 citations

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Isolation and characterization of a mutant deficient in the activity of phosphoribosylaminoimidazole synthetase

1979 • 15 citations

Establishment of the interferon-mediated antiviral state: Role of fatty acid cyclooxygenase

1981 • 15 citations

Somatostatin levels in the central nervous system of the Snell dwarf mouse; is somatostatin excess the primary molecular defect in the dw/dw dwarfism?

1985 • 14 citations

Assignment of the genes coding for pyrophosphatase and hexokinase-1 to mouse chromosome 10: implications for comparative gene mapping in man and mouse

1978 • 13 citations

Linkage of the Igl-1 structural and regulatory genes to Akv-2 on chromosome 16

1984 • 13 citations

Regional mapping of liver type 6 phosphofructokinase isoenzyme on chromosome 21

1984 • 13 citations

1306 NEURAL CREST INVOLVEMENT IN MOUSE TRISOMY 16 EMBRYOPATHY

1985 • 10 citations

1308 DEVELOPMENT OF THE HIPPOCAMPAL FORMATION IN TRISOMY 16 MICE

1985 • 9 citations

Assignment of the genes for mouse type I procollagen to chromosome 16 using mouse fibroblast-Chinese hamster somatic cell hybrids

1983 • 9 citations

Indophenol-oxidase in patients with Down's syndrome due to simple trisomy and to translocation 21/22

1976 • 8 citations

Inborn errors in metabolism in humans

1983 • 8 citations

Selective culture medium enhances survival of neuroblasts from postnatal rodent brain

1986 • 6 citations

Vesicular stomatitis virus induced membrane changes: A spin label study

1984 • 6 citations

850 GENETIC LOCALIZATION OF THE DOWN SYNDROME REGION IN THE MOUSE

1985 • 1 citations