Identification of a Surface for Binding to the GDNF-GFRα1 Complex in the First Cadherin-like Domain of RET

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

RASMOL: biomolecular graphics for all

1995 • 2,601 citations

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

The GDNF family: Signalling, biological functions and therapeutic value

2002 • 1,722 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules

1998 • 1,038 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms

2002 • 663 citations

The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands

2003 • 597 citations

Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

2003 • 593 citations

The GDNF family ligands and receptors — implications for neural development

2000 • 464 citations

ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

1987 • 346 citations

Structure-Function Analysis of Cell Adhesion by Neural (N-) Cadherin

1998 • 327 citations

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1997 • 302 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase

1998 • 188 citations

Neuroprotective and neurorestorative properties of GDNF

1998 • 157 citations

Molecular Modeling of the Extracellular Domain of the RET Receptor Tyrosine Kinase Reveals Multiple Cadherin-like Domains and a Calcium-binding Site

2001 • 157 citations

Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

1996 • 132 citations

Distinct structural elements in GDNF mediate binding to GFRalpha 1 and activation of the GFRalpha 1-c-Ret receptor complex

1999 • 125 citations

Characterization of the ret proto-oncogene products expressed in mouse L cells.

1993 • 88 citations

Ret in human development and oncogenesis

1997 • 79 citations

Calcium-dependent Ret activation by GDNF and neurturin

1998 • 70 citations

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor

1998 • 67 citations

Determinants of Ligand Binding Specificity in the Glial Cell Line-derived Neurotrophic Factor Family Receptor αs

2001 • 65 citations

Functional Mapping of Receptor Specificity Domains of Glial Cell Line-derived Neurotrophic Factor (GDNF) Family Ligands and Production of GFRα1 RET-specific Agonists

2000 • 64 citations

Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET

2003 • 59 citations

Defining the Factor Xa-binding Site on Factor Va by Site-directed Glycosylation

2002 • 44 citations

Molecular mechanisms of RET activation in human neoplasia

1999 • 41 citations

Expression of the Receptor Tyrosine Kinase Ret on the Plasma Membrane Is Dependent on Calcium

1998 • 38 citations