Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

The MAPK signaling cascade

1995 • 3,300 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress

1985 • 699 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Induction of human vascular endothelial stress fibres by fluid shear stress

1984 • 538 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy.

1994 • 343 citations

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

1991 • 333 citations

Stabilizing Infrastructure of Cell Membranes

1985 • 317 citations

Single-Chain Antibody-Mediated Intracellular Retention of ErbB-2 Impairs Neu Differentiation Factor and Epidermal Growth Factor Signaling

1995 • 300 citations

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

1995 • 284 citations

Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo

1988 • 246 citations

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene

1986 • 225 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Animal cell shape changes and gene expression

1991 • 212 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

The cytoskeleton in cancer cells

1985 • 170 citations

Actin-binding proteins

1990 • 164 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Production of plasminogen activator by migrating cephalic neural crest cells.

1985 • 149 citations

Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas.

1987 • 136 citations

Microfilament-organizing centers in areas of cell contact: cytoskeletal interactions during cell attachment and locomotion.

1984 • 136 citations

Molecular aspects of signal transduction of shear stress in the endothelial cell

1994 • 126 citations

cDNA and gene nucleotide sequence of porcine plasminogen activator

1984 • 116 citations

p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells

1995 • 112 citations

Endothelial adherence under shear stress is dependent upon microfilament reorganization

1989 • 104 citations

Induction and desensitization of plasminogen activator gene expression by tumor promoters.

1985 • 103 citations

Translation and the cytoskeleton: a mechanism for targeted protein synthesis

1994 • 93 citations

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

1995 • 82 citations

Multiple instability-regulating sites in the 3' untranslated region of the urokinase-type plasminogen activator mRNA.

1994 • 78 citations

Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression.

1990 • 76 citations

Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion.

1993 • 70 citations

Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation.

1989 • 69 citations

Effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly

1990 • 64 citations

A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways

1995 • 55 citations

Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK₁cells

1993 • 55 citations

Cytoskeleton-associated proteins: their role as cellular integrators in the neoplastic process

1985 • 50 citations

Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.

1989 • 49 citations

Effect of shear stress upon localization of the Golgi apparatus and microtubule organizing center in isolated cultured endothelial cells

1993 • 49 citations

Malignant transformation of human fibroblasts correlates with increased activity of receptor-bound plasminogen activator.

1991 • 46 citations

Complexity and versatility of the transcriptional response to cAMP

1994 • 43 citations

Activation of microtubule-associated protein kinase by microtubule disruption in quiescent rat 3Y1 cells

1991 • 40 citations

Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells.

1991 • 39 citations

Urokinase-type plasminogen activator gene regulation by polyomavirus middle-T antigen.

1995 • 25 citations

hsp70 mRNA accumulates in LLC-PK1 pig kidney cells treated with calcitonin but not with 8-bromo-cyclic AMP.

1988 • 23 citations

The reorganization of microtubules and microfilaments in differentiating keratinocytes

1987 • 22 citations

Actin filaments and acetylcholine receptor clusters in embryonic chick myotubes.

1985 • 13 citations