Effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Tissue Culture. Methods and Applications

1974 • 1,068 citations

Amiloride: a molecular probe of sodium transport in tissues and cells

1982 • 837 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

1987 • 503 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

An epithelial scatter factor released by embryo fibroblasts

1985 • 368 citations

Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.

1984 • 342 citations

Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

1985 • 308 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

1987 • 263 citations

Phospholipid-sensitive calcium-dependent protein kinase: Inhibition by antipsychotic drugs

1981 • 243 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Vinculin, a cytoskeletal substrate of protein kinase C.

1983 • 215 citations

Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

1989 • 210 citations

Biological activities of the two major components of tunicamycin.

1979 • 204 citations

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

1985 • 179 citations

Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure

1989 • 158 citations

Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts.

1989 • 153 citations

A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors

1982 • 144 citations

Smooth muscle releases an epithelial cell scatter factor which binds to heparin

1989 • 136 citations

Effect of scatter factor on motility of epithelial cells and fibroblasts

1989 • 102 citations

Protein factors which regulate cell motility

1989 • 100 citations

Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads

1990 • 90 citations

Purified Scatter Factor Stimulates Epithelial and Vascular Endothelial Cell Migration

1990 • 86 citations

Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures.

1987 • 76 citations

Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C.

1988 • 72 citations

Tumor promoters induce a specific morphological signature in the nuclear matrix-intermediate filament scaffold of Madin-Darby canine kidney (MDCK) cell colonies.

1984 • 70 citations

Evidence against interconversion of microtubules and filaments

1975 • 69 citations

High affinity binding of [3H]dihydrocytochalasin B to peripheral membrane proteins related to the control of cell shape in the human red cell.

1978 • 68 citations

Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists

1985 • 62 citations

Specific desensitization to tumor-promoting phorbol esters in mouse pituitary cells. Evidence that desensitization is a two-step process.

1983 • 61 citations

Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis

1986 • 60 citations

Protein kinase C inhibitor H‐7 alters the actin cytoskeleton of cultured cells

1989 • 54 citations

Protein kinase C activation and down‐regulation in relation to phorbol ester‐induced differentiation of SH‐SY5Y human neuroblastoma cells

1989 • 48 citations

The shape of cultured epithelial cells does not depend on the integrity of their microtubules

1988 • 40 citations

Decline in c-myc mRNA expression but not the induction of c-fos mRNA expression is associated with differentiation of SH-SY5Y human neuroblastoma cells

1988 • 39 citations

Analysis of desmin and vimentin phosphopeptides in cultured avian myogenic cells and their modulation by 8-bromo-adenosine 3',5'-cyclic monophosphate.

1982 • 35 citations

Actin stress fiber disruption and tropomyosin isoform switching in normal thyroid epithelial cells stimulated by thyrotropin and phorbol esters

1989 • 33 citations

Association of phorbol ester receptor down modulation with a cryptic receptor state.

1983 • 23 citations

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase

1986 • 22 citations

The effects of tubulazole, a new synthetic microtubule inhibitor on experimental neoplasms

1984 • 19 citations

Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures.

1979 • 19 citations