The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.

1982 • 932 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias.

1994 • 318 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias in Mice

1988 • 275 citations

Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs.

1995 • 209 citations

Apoptosis (Programmed Cell Death) in Arteries of the Neonatal Lamb

1995 • 200 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Programmed Cell Death and Expression of the Protooncogene bcl-2 in Myocytes during Postnatal Maturation of the Heart

1995 • 177 citations

Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.

1993 • 170 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

Adenovirus E1A Represses Cardiac Gene Transcription and Reactivates DNA Synthesis in Ventricular Myocytes, via Alternative Pocket Protein- and p300-binding Domains

1995 • 153 citations

Involvement of p53 Expression in cAMP-Mediated Apoptosis in Immortalized Granulosa Cells

1995 • 103 citations

The involvement of oncogenes and tumor suppressor genes in the control of apoptosis

1992 • 99 citations

Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone.

1995 • 94 citations

Direct involvement of p53 in programmed cell death of oligodendrocytes.

1995 • 89 citations

p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins.

1995 • 86 citations

Tumor suppressor gene expression during normal and pathologic myocardial growth.

1994 • 76 citations

Positive and negative control of the skeletal alpha-actin promoter in cardiac muscle. A proximal serum response element is sufficient for induction by basic fibroblast growth factor (FGF) but not for inhibition by acidic FGF.

1992 • 60 citations

Heterodimerization with Bax is Required for Bcl-2 to Repress Cell Death

1995 • 57 citations

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1995 • 48 citations

In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection.

1994 • 37 citations

Identification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice

1993 • 33 citations