Human embryonic stem cells: multilineage differentiation and mechanisms of self-renewal

Embryonic Stem Cell Lines Derived from Human Blastocysts

1998 • 15,541 citations

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

2003 • 3,230 citations

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

2003 • 3,179 citations

Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

2000 • 2,733 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

2001 • 1,874 citations

Feeder-free growth of undifferentiated human embryonic stem cells

2001 • 1,860 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1998 • 1,518 citations

Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture

2000 • 1,488 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

1978 • 1,303 citations

Embryo-Derived Stem Cells: Of Mice and Men

2001 • 1,274 citations

Placental development: Lessons from mouse mutants

2001 • 1,239 citations

Isolation of a primate embryonic stem cell line.

1995 • 1,113 citations

Neural progenitors from human embryonic stem cells

2001 • 1,113 citations

BMP4 initiates human embryonic stem cell differentiation to trophoblast

2002 • 1,107 citations

Multilineage Differentiation from Human Embryonic Stem Cell Lines

2001 • 982 citations

New Human Tumor Cell Lines

1975 • 974 citations

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes

2003 • 966 citations

Hematopoietic colony-forming cells derived from human embryonic stem cells

2001 • 933 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

Insulin Production by Human Embryonic Stem Cells

2001 • 913 citations

Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells

2002 • 906 citations

Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells

1996 • 860 citations

Endothelial cells derived from human embryonic stem cells

2002 • 796 citations

Human Embryonic Stem Cells Develop Into Multiple Types of Cardiac Myocytes

2003 • 781 citations

Teratocarcinomas and Mammalian Embryogenesis

1980 • 767 citations

Human Tumor Cells in Vitro

1975 • 753 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells

2002 • 735 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Alkaline Phosphatase Activity in Mouse Teratoma

1973 • 630 citations

Human embryonic stem cells

2000 • 569 citations

Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells

1999 • 569 citations

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

1987 • 567 citations

Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells.

1983 • 535 citations

Enrichment of Neurons and Neural Precursors from Human Embryonic Stem Cells

2001 • 502 citations

A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells

2003 • 501 citations

Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens

2002 • 483 citations

Surface antigens of human embryonic stem cells: changes upon differentiation in culture*

2002 • 477 citations

Human Feeder Layers for Human Embryonic Stem Cells1

2003 • 457 citations

Induced neuronal differentiation of human embryonic stem cells

2001 • 435 citations

Pluripotent Cell Lines Derived from Common Marmoset (Callithrix jacchus) Blastocysts1

1996 • 410 citations

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

1987 • 403 citations

Monoclonal antibody to murine embryos defines a stage-specific embryonic antigen expressed on mouse embryos and human teratocarcinoma cells

1982 • 366 citations

Human Adult Marrow Cells Support Prolonged Expansion of Human Embryonic Stem Cells in Culture

2003 • 333 citations

High-Resolution Electrophysiological Assessment of Human Embryonic Stem Cell-Derived Cardiomyocytes

2002 • 309 citations

Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines

2001 • 264 citations

Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes

1991 • 262 citations

Teratocarcinoma stem cells

1983 • 250 citations

Derivation and spontaneous differentiation of human embryonic stem cells*

2002 • 219 citations

A comparative study of eight cell lines derived from human testicular teratocarcinoma

1980 • 212 citations

Cell‐surface antigens of a clonal human embryonal carcinoma cell line: Morphological and antigenic differentiation in culture

1982 • 200 citations

Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells

1999 • 189 citations

Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.

1989 • 186 citations

Teratocarcinomas and human embryology: Pluripotent human EC cell lines

1998 • 139 citations

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway

1998 • 126 citations

Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines

2001 • 107 citations

The cDNA sequence and chromosomal location of the human SOX2 gene

1994 • 100 citations

Immunohistochemical localization of murine stage-specific embryonic antigens in human testicular germ cell tumors.

1982 • 82 citations

Two Monoclonal Antibodies Recognizing Determinants on Human Embryonal Carcinoma Cells React Specifically with the Liver Isozyme of Human Alkaline Phosphatase

1984 • 48 citations

Differential expression of two homologous and clustered oncogenes, Hst1 and Int-2, during differentiation of F9 cells

1988 • 48 citations

Human embryonal carcinoma cells in culture do not synthesize fibronectin until they differentiate

1982 • 42 citations

Do human concepti have the potential to enter into diapause?

1999 • 29 citations

Teratocarcinomas rarely develop from embryos transplanted into athymic mice

1979 • 27 citations

Human Embryonic Stem Cells

2004 • 18 citations

Embryonal Carcinoma Cells: The Malignant Counterparts of ES and EG Cells

2003 • 1 citations