Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

2000 • 896 citations

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

2000 • 837 citations

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

1998 • 783 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

1996 • 726 citations

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

1996 • 649 citations

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1998 • 647 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Isoform-specific binding of apolipoprotein E to beta-amyloid.

1994 • 529 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

α ₂ “Macroglobulin, a multifunctional binding protein with targeting characteristics

1992 • 454 citations

Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture

1995 • 365 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

1999 • 342 citations

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease

1997 • 303 citations

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α₂‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

1995 • 297 citations

LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism

1995 • 272 citations

α₂‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

1997 • 259 citations

Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP)

2000 • 256 citations

The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant

1996 • 206 citations

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.

1992 • 177 citations

Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A Evidence that this protein is required for uptake and degradation of multiple ligands

1994 • 167 citations

Neuropathology in controls and demented subjects from the Baltimore longitudinal study of aging

1996 • 138 citations

Interaction of Nascent ApoE2, ApoE3, and ApoE4 Isoforms Expressed in Mammalian Cells with Amyloid Peptide β (1−40). Relevance to Alzheimer's Disease

1997 • 135 citations

α₂‐Macroglobulin Enhances the Clearance of Endogenous Soluble β‐Amyloid Peptide via Low‐Density Lipoprotein Receptor‐Related Protein in Cortical Neuron

1999 • 134 citations

alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.

1997 • 131 citations

Confirmation of an association between a polymorphism in exon 3 of the low‐density lipoprotein receptor‐related protein gene and Alzheimer's disease

1998 • 124 citations

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)

1996 • 113 citations

Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner

1999 • 111 citations

α₂‐Macroglobulin as a β‐Amyloid Peptide‐Binding Plasma Protein

1997 • 108 citations

Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma.

1993 • 100 citations

Expression of ?2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

2000 • 87 citations

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene

1998 • 80 citations

Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese

1998 • 61 citations

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease

1999 • 53 citations

The expression of megalin (gp330) and LRP diverges during F9 cell differentiation

1995 • 49 citations

Amyloid β Peptide Formation in Cell-free Preparations

1996 • 49 citations

α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites

1983 • 16 citations

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