Chromatographic and electrophoretic analysis of biomedically important retinoids

Modern Nutrition in Health and Disease.

1988 • 3,468 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Modern Nutrition in Health and Disease

1994 • 1,201 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Analytical Methods Validation: Bioavailability, Bioequivalence, and Pharmacokinetic Studies

1992 • 1,134 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

The retinoids; Biology, chemistry, and medicine

1994 • 400 citations

Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard.

1988 • 393 citations

Simultaneous determination of retinol, α-tocopherol and β-carotene in serum by isocratic high-performance liquid chromatography

1991 • 329 citations

Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia.

1992 • 295 citations

Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase.

1991 • 286 citations

The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification

1993 • 285 citations

Retinol, alpha-tocopherol, lutein/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, trans-beta-carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection

1994 • 256 citations

A method for determining concentrations of retinol, tocopherol, and five carotenoids in human plasma and tissue samples

1992 • 254 citations

Modern Chromatographic Analysis of Vitamins

1992 • 253 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

Retinoids: New Trends in Research and Therapy

1986 • 252 citations

The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.

1992 • 237 citations

Effects of storage and handling conditions on concentrations of individual carotenoids, retinol, and tocopherol in plasma.

1988 • 227 citations

VITAMIN A AND RETINOIDS: FROM NUTRITION TO PHARMACOTHERAPY IN DERMATOLOGY AND ONCOLOGY

1983 • 218 citations

Modern nutrition in health and disease. 8th ed.

1994 • 206 citations

Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations.

1993 • 205 citations

Fully automated high-performance liquid chromatography

1981 • 200 citations

Liquid chromatographic method for the determination of carotenoids, retinoids and tocopherols in human serum and in food

1993 • 194 citations

Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.

1990 • 172 citations

Changing Patterns of the Retinoic Acid System in the Developing Retina

1993 • 165 citations

The Retinoids: Biology, Chemistry and Medicine, 2nd ed

1994 • 156 citations

All-trans-retinoic acid: measurement of reference values in human serum by high performance liquid chromatography

1982 • 153 citations

Quantitative determination of retinals with complete retention of their geometric configuration

1980 • 145 citations

Vitamin A in Human Skin: II Concentrations of Carotene, Retinol and Dehydroretinol in Various Components of Normal Skin

1982 • 145 citations

Plasma retinol level reduction by the synthetic retinoid fenretinide: a one year follow-up study of breast cancer patients.

1989 • 140 citations

Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid

1994 • 130 citations

Chromatographic determination of vitamins in foods

1992 • 129 citations

Reported effects of long-term freezer storage on concentrations of retinol, beta-carotene, and alpha-tocopherol in serum or plasma summarized

1993 • 127 citations

Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.

1985 • 126 citations

Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro.

1992 • 126 citations

Retinoids : new trends in research and therapy

1985 • 125 citations

High-performance liquid chromatographic method for routine determination of vitamins A and E and β-carotene in plasma

1992 • 125 citations

Serum concentrations of carotenoids, retinol, and α-tocopherol in healthy persons determined by high-performance liquid chromatography

1990 • 119 citations

Retinoids: progress in research and clinical applications

1993 • 119 citations

Retinol and retinal metabolism. Relationship to the state of differentiation of cultured human keratinocytes

1990 • 116 citations

Teratogenicity and placental transfer of All-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low oral dose during organogenesis in mice

1989 • 115 citations

New simplified procedures for the extraction and simultaneous high-performance liquid chromatographic analysis of retinol, tocopherols and carotenoids in human serum

1993 • 111 citations

Retinoic acid: An endogenous compound of human blood. Unequivocal demonstration of endogenous retinoic acid in normal physiological conditions

1979 • 110 citations

Column-switching techniques for high-performance liquid chromatography of drugs in biological samples

1993 • 108 citations

13-cis-retinoic acid is an endogenous compound in human serum.

1990 • 108 citations

Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

1982 • 105 citations

Determination of retinol, alpha-tocopherol, and beta-carotene in serum by liquid chromatography with absorbance and electrochemical detection.

1987 • 103 citations

Conversion of Acitretin to Etretinate in Psoriatic Patients Is Influenced by Ethanol

1993 • 103 citations

Retinoid concentrations in skin, serum and adipose tissue of patients treated with etretinate*

1983 • 103 citations

Retinoyl β-glucuronide: an endogenous compound of human blood

1986 • 101 citations

Characterization of retinol metabolism in cultured human epidermal keratinocytes

1993 • 100 citations

Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: Comparison to the all-trans isomer

1987 • 95 citations

Vitamin A in Human Skin: I. Detection and Identification of Retinoids in Normal Epidermis

1982 • 93 citations

[13] Quantification of physiological levels of retinoic acid

1986 • 93 citations

Separation of long-chain fatty acid esters of retinol by high-performance liquid chromatography

1981 • 93 citations

Simultaneous determination of vitamins A and E and carotenoids in plasma by reversed-phase HPLC in elderly and younger subjects

1993 • 90 citations

Vitamin A2-based visual pigments in fully terrestrial vertebrates

1992 • 90 citations

Retinol secretion by the lacrimal gland.

1986 • 89 citations

4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse

1992 • 88 citations

Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

1982 • 85 citations

Uptake and metabolism of β-carotene and retinal by C3H/10T1/2 cells

1988 • 85 citations

Distribution of fenretinide in the mammary gland of breast cancer patients

1991 • 84 citations

Simple determination of retinol, α-tocopherol and carotenoids (lutein, all-trans-lycopene, α- and β-carotenes) in human plasma by isocratic liquid chromatography

1994 • 83 citations

High-pressure liquid chromatographic determination of 13-cis-retinoic acid and all-trans-retinoic acid in human plasma

1978 • 80 citations

Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching

1988 • 79 citations

Determination of several retinoids, carotenoids and E vitamers by high-performance liquid chromatography

1991 • 77 citations

[8] Separation and quantitation of retinyl esters and retinol by high-performance liquid chromatography

1986 • 77 citations

Protocol for the study of the metabolism of retinyl esters in plasma lipoproteins during postprandial lipemia.

1992 • 77 citations

Metabolism of all-trans-retinoic acid and all-trans-retinyl acetate. Demonstration of common physiological metabolites in rat small intestinal mucosa and circulation.

1985 • 76 citations

Metabolism in vivo of all-trans-retinoic acid. Biosynthesis of 13-cis-retinoic acid and all-trans- and 13-cis-retinoyl glucuronides in the intestinal mucosa of the rat.

1982 • 75 citations

Simultaneous measurement of serum retinol, tocopherols, carotenes, and carotenoids by high performance liquid chromatography

1987 • 75 citations

Dose-dependent kinetics of all-trams-retinoic acid in rats

1981 • 73 citations

Nomenclature of Retinoids

1982 • 72 citations

Pharmacology of 13-cis-retinoic acid in humans.

1982 • 71 citations

Determination of isotretinoin or etretinate and their major metabolites in human blood by reversed-phase high-performance liquid chromatography

1985 • 70 citations

Chromatography of fat-soluble vitamins in clinical chemistry

1988 • 67 citations

Human Plasma all-trans-, 13-cis- and 13-cis-4-Oxoretinoic Acid Profiles during Subchronic Vitamin A Supplementation: Comparison to Retinol and Retinyl Ester Plasma Levels

1991 • 66 citations

Determination of vitamins A and E in liver tissue.

1992 • 65 citations

Simultaneous analysis of individual carotenoids, retinol, retinyl esters, and tocopherols in serum by isocratic non-aqueous reversed-phase HPLC

1993 • 64 citations

Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.

1991 • 63 citations

Derivation of retinoic acid and metabolites from a teratogenic dose of retinol (vitamin A) in mice

1988 • 62 citations

Pharmacokinetics of n‐4‐hydroxyphenyl‐retinamide and the effect of its oral administration on plasma retinol concentrations in cancer patients

1989 • 62 citations

A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human tissues.

1993 • 61 citations

Separation and estimation of retinyl fatty acyl esters in tissues of normal rat by high-performance liquid chromatography

1983 • 60 citations

Uptake, processing and release of retinoids by cultured human retinal pigment epithelium

1990 • 60 citations

Separation of retinyl esters by non-aqueous reversed-phase high-performance liquid chromatography

1986 • 58 citations

Gradient reversed-phase high-performance liquid chromatographic separation of naturally occurring retinoids

1984 • 58 citations

9-cis-retinoic acid, a potent inducer of digit pattern duplications in the chick wing bud

1993 • 57 citations

Intestinal perfusion of β -carotene in the ferret raises retinoic acid level in portal blood

1993 • 56 citations

Transplacental pharmacokinetics and teratogenicity of a single dose of retinol (vitamin A) during organogenesis in the mouse

1989 • 56 citations

Serum carotenoids and retinoids in ferrets fed canthaxanthin

1993 • 56 citations

Rapid, simultaneous determination of isomers of retinal, retinal oxime and retinol by high-performance liquid chromatography

1988 • 55 citations

Chromatography of retinoids

1990 • 54 citations

Food Increases the Bioavailability of Acitretin

1988 • 54 citations

Disposition of all-trans-retinoic acid in mice following oral doses.

1981 • 53 citations

Oral Isotretinoin (13-cis-Retinoic Acid) Therapy in Severe Acne: Drug and Vitamin A Concentrations in Serum and Skin

1986 • 53 citations

Rapid analysis of the major classes of retinoids by step gradient reversed-phase high-performance liquid chromatography using retinal (O-ethyl) oxime derivatives

1985 • 53 citations

Gas chromatographic—mass spectrometric assay for low levels of retinoic acid in human blood

1980 • 53 citations

N-(4-hydroxyphenyl)-all-trans-retinamide pharmacokinetics in female rats and mice.

1986 • 53 citations

Variability in the Oral Bioavailability of All-trans-Retinoic Acid

1993 • 52 citations

Disposition of all-trans- and 13-cis-retinoic acids and n-hydroxyethylretinamide in mice after intravenous administration.

1980 • 51 citations

4-Hydroxyretinal, a new visual pigment chromophore found in the bioluminescent squid, Watasenia scintillans

1988 • 51 citations

Determiation of retinoic acid (13-cis- and all-trans-) and aromatic retinoic acid analogs possessing anti-tumor activity, in biological fluids by high-performance liquid chromatography

1978 • 51 citations

Determination of 13-cis-retinoic acid and its major metabolite, 4-oxo-13-cis-retinoic acid, in human blood by reversed-phase high-performance liquid chromatography

1982 • 50 citations

The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid

1994 • 49 citations

Etretinate. Persistent serum levels after long-term therapy

1989 • 48 citations

Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo

1989 • 48 citations

A simple procedure for the extraction of the native chromophore of visual pigments: The formaldehyde method

1986 • 47 citations

Isotretinoin in Lacrimal Gland Fluid and Tears

1987 • 46 citations

Reversed-phase high-performance liquid chromatographic separation and electrochemical detection of retinol and its isomers

1987 • 45 citations

Effects of Meals and Meal Composition on the Bioavailability of Fenretinide

1992 • 45 citations

Automated Determination of 13-Cis-and All-Trans-Retinoic Acid, Their 4-Oxo-Metabolites and Retinol in Plasma, Amniotic Fluid and Embryo by Reversed-Phase High-Performance Liquid Chromatography with a Precolumn Switching Technique

1988 • 45 citations

Pharmacokinetics of 13-cis-retinoic acid in patients with advanced cancer.

1982 • 45 citations

Effect of silver ions on the reversed phase high performance liquid chromatographic separation of retinyl esters

1979 • 45 citations

Effect of tetrachlorodibenzo-p-dioxin (TCDD) on the glucuronidation of retinoic acid in the rat

1989 • 44 citations

[15] Simultaneous, high-performance liquid chromatographic analysis of retinol, tocopherols, lycopene, and α- and β-carotene in serum and plasma

1990 • 44 citations

A Rapid Separation of Ten Carotenoids, Three Retinoids, Alpha-Tocopherol and d-Alpha-Tocopherol Acetate by High Performance Liquid Chromatography and its Application to Serum and Vegetable Samples

1990 • 43 citations

Separation and identification of retinoic acid photo-isomers

1989 • 43 citations

Pharmacokinetics of N-(4-hydroxyphenyl)-all-trans-retinamide in rats.

1980 • 42 citations

An improved protocol for determining ratios of retinol-d4 to retinol isolated from human plasma

1993 • 42 citations

Determination of highly protein bound in plasma using high-performance liquid chromatography and column switching, exemplified by the retinoids

1988 • 41 citations

Nonenzymatic isomerization of all-trans- and 13-cis-retinoids catalyzed by sulfhydryl groups.

1986 • 40 citations

PHOTOISOMERIZATION OF RETINOIC ACID AND ITS PHOTOPROTECTION IN PHYSIOLOGIC‐LIKE SOLUTIONS

1988 • 40 citations

[17] Determination of retinol, α-tocopherol, and β-carotene in serum by liquid chromatography

1990 • 39 citations

Quantitation of biological retinoids by high-pressure liquid chromatography: Primary internal standardization using tritiated retinoids

1986 • 39 citations

Isotretinoin (13‐cis‐retinoic acid) metabolism, cis‐trans isomerization, glucuronidation, and transfer to the mouse embryo: Consequences for teratogenicity

1991 • 38 citations

The formation of all-trans-retinoic acid from all-trans-retinol in hairless mouse skin

1987 • 37 citations

Characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry

1990 • 37 citations

Fast minimicroassay of serum retinol (vitamin A) by capillary zone electrophoresis with laser-excited fluorescence detection

1993 • 37 citations

Determination of an aromatic retinoid and its main metabolite by high-performance liquid chromatography

1979 • 36 citations

High-performance liquid chromatography of the unsaponifiable from samples of marine and freshwater fish: fractionation and identification of retinol (vitamin A1) and dehydroretinol (vitamin A2) isomers

1984 • 36 citations

Disposition of 13-cis-retinoic acid and N-(2-hydroxyethyl)retinamide in mice after oral doses.

1982 • 35 citations

Etretinate

1989 • 35 citations

Chemical synthesis of all-trans-[11-3H]retinoyl β-glucuronide and its metabolism in rats in vivo

1989 • 35 citations

Characterization of retinyl beta-glucuronide in human blood

1989 • 34 citations

Simultaneous determination of endogenous retinoic acid isomers and retinol in human plasma by isocratic normal-phase HPLC with ultraviolet detection

1994 • 34 citations

Separation and identification of geometric isomers of 3-hydroxyretinoids and occurrence in the eyes of insects

1986 • 33 citations

Evidence for Percutaneous Absorption of Isotretinoin from the Photo-Isomerization of Topical Tretinoin

1989 • 33 citations

Simultaneous liquid chromatographic determination of carotenoids, retinoids, and tocopherols in human buccal mucosal cells.

1992 • 32 citations

Micro liquid chromatography—mass spectrometry with direct liquid introduction used for separation and quantitation of all-trans- and 13-cis-retinoic acids and their 4-oxo metabolites in human plasma

1993 • 31 citations

Separation of 13-cis and all-trans retinoic acid and their photodegradation products using capillary zone electrophoresis and micellar electrokinetic chromatography (MEC)

1993 • 31 citations

High-performance liquid chromatography of 13-cis-retinoic acid and of endogenous retinol in human plasma

1980 • 30 citations

9-cis-retinoic acid: A direct-acting dysmorphogen

1993 • 30 citations

[13] Analysis of water-soluble compounds: glucuronides

1990 • 30 citations

Simultaneous determination of endogenous retinoic acid isomers and retinol in human plasma by isocratic normal-phase HPLC with ultraviolet detection.

1994 • 30 citations

[53] Quantification and characteristics of retinoid synthesis from retinol and β-carotene in tissue fractions and established cell lines

1990 • 30 citations

Separation of cis and trans double-bond isomers using capillary zone electrophoresis

1991 • 30 citations

Analysis and Stability of Retinol in Plasma2

1987 • 29 citations

Separation and identification of triglycerides, cholesteryl esters, cholesterol, 7-dehydrocholesterol, dolichol, ubiquinone, alpha-tocopherol, and retinol by high performance liquid chromatography with a diode array detector

1988 • 29 citations

Biosynthesis of retinoyl-β-glucuronide, a biologically active metabolite of all-trans-retinoic acid

1986 • 28 citations

Teratogenicity and Transplacental Pharmacokinetics of 13-cis-Retinoic Acid in Rabbits

1994 • 27 citations

Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching

1988 • 27 citations

Determination of etretinate and its main metabolite in human plasma using normal-phase high-performance liquid chromatography

1983 • 27 citations

Use of direct injection procolumn techniques for the high-performance liquid chromatographic determination of the retinoids acitretin and 13-cis-acitretin in plasma

1992 • 26 citations

Simultaneous determination of the aromatic retinoids etretin and etretinate and their main metabolites by reversed-phase liquid chromatography

1987 • 26 citations

Alteration of retinol-binding-protein concentrations by the synthetic retinoid fenretinide in healthy human subjects

1990 • 26 citations

Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice

1988 • 25 citations

Acitretin Biotransformation into Etretinate: Role of Ethanol on in vitro Hepatic Metabolism

1994 • 25 citations

Single-run analysis of isomers of retinoyl-β-D-glucuronide and retinoic acid by reversed-phase high-performance liquid chromatography

1994 • 25 citations

Simultaneous determination of retinol and tocopherols by high-performance liquid chromatography

1992 • 25 citations

Determination of plasma levels of two aromatic retinoic acid analogues with antipsoriatic activity by high-performance liquid chromatography

1980 • 25 citations

Teratogenicity of Steady-State Concentrations of Etretinate and Metabolite Acitretin Maintained in Maternal Plasma and Embryo by Intragastric Infusion during Organogenesis in the Mouse: A Possible Model for the Extended Elimination Phase in Human Therapy

1990 • 24 citations

Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application

1989 • 24 citations

Voltammetric behaviour of all-trans-retinol (vitamin A1) at a glassy carbon electrode and its determination in human serum using high-performance liquid chromatography with electrochemical detection

1988 • 24 citations

Pharmacokinetic assessment of teratologically effective concentrations of an endogenous retinoic acid metabolite

1989 • 23 citations

Human biliary metabolites of isotretinoin: identification, quantification, synthesis, and biological activity

1990 • 23 citations

Metabolism in vivo of all-trans-[11-3H]retinoic acid after an oral dose in rats. Characterization of retinoyl β-glucuronide in the blood and other tissues

1991 • 23 citations

A potentially new metabolic pathway: ethyl esterification of acitretin

1992 • 23 citations

Correlations between conceptal concentrations of all-trans-retinoic acid and dysmorphogenesis after microinjections of all-trans-retinoic acid, 13-cis-retinoic acid, all-trans-retinoyl-beta-glucuronide, or retinol in cultured whole rat embryos.

1992 • 22 citations

カラムスイッチング高速液体クロマトグラフィーによる生体液中レチノイド類の定量分析 II 血しょう中エトレチナート,アシトレチンおよび13-cis-アシトレチンの同時定量

1988 • 22 citations

Simultaneous determination of 13-cis- and all-trans-retinoic acids and retinol in human serum by high-performance liquid chromatography

1994 • 22 citations

[18] Separation of retinyl esters and their geometric isomers by isocratic adsorption high-performance liquid chromatography

1990 • 22 citations

Metabolism of the chemopreventive retinoid N-(4-hydroxyphenyl)retinamide by mammary gland in organ culture

1988 • 22 citations

Distribution of retinol isomerase in vertebrate eyes and its emergence during retinal development

1989 • 22 citations

Tissue levels of retinoids in human embryos/fetuses

1993 • 22 citations

Systemic pharmacokinetics of acitretin, etretinate, isotretinoin, and acetylenic retinoids in guinea pigs and obese rats.

1992 • 21 citations

Simple high-performance liquid chromatographic method for the separation of retinoids including N-(4-hydroxyphenyl)-all-trans-retinamide

1985 • 21 citations

[8] Reversed-phase high-performance liquid chromatography of retinyl esters

1990 • 21 citations

Analysis of retinoids by high-performance liquid chromatography using programmed gradient separation

1984 • 21 citations

Teratogenicity of the 13‐cis and all‐trans‐isomers of the aromatic retinoid etretin: Correlation to transplacental pharmacokinetics in mice during organogenesis after a single oral dose

1990 • 21 citations

High-performance liquid chromatography of natural and synthetic retinoids in human skin samples

1990 • 20 citations

Determination of orally administered all-trans-retinoic acid in human plasma by high-performance liquid chromatography

1994 • 20 citations

Changes of egg retinoids during the development of Xenopus laevis

1990 • 20 citations

Increased concentrations of endogenous 13-cis- and all-trans-retinoic acids in diffuse idiopathic skeletal hyperostosis, as demonstrated by HPLC

1991 • 20 citations

Pharmacokinetics and drug interactions of etretinate and acitretin

1992 • 20 citations

The pharmacokinetics of all-trans-retinoic acid and N-(2-hydroxyethyl)retinamide in mice as determined with a sensitive and convenient procedure. Solid-phase extraction and reverse-phase high performance liquid chromatography.

1987 • 20 citations

Routine clinical determination of carotene, vitamin E, vitamin A, 25‐hydroxy vitamin D3 and trans‐vitamin K1 in human serum by straight phase HPLC

1987 • 19 citations

High-performance liquid chromatography of Ro 10-9359 (Tigason) and its metabolite Ro 10-1670 in human plasma

1982 • 19 citations

[6] High-performance liquid chromatography of retinoid isomers

1990 • 19 citations

Simultaneous determination of retinol, α-tocopherol and retinyl palmitate in plasma of premature newborns by reversed-phase high-performance liquid chromatography

1993 • 18 citations

[25] Analysis of apocarotenoids and retinoids by capillary gas chromatography-mass spectrometry

1992 • 18 citations

Gas chromatography of retinol and α-tocopherol without derivatization

1988 • 18 citations

Determination of Acitretin in the Skin, in the Suction Blister, and in Plasma of Human Volunteers after Multiple Oral Dosing

1994 • 18 citations

Quantitative plasma disposition of retinol and retinyl esters after high-dose oral vitamin A administration in the cynomolgus monkey

1992 • 18 citations

Plasma concentrations of β‐carotene, vitamin A and vitamin E after β‐carotene and vitamin E intake

1993 • 18 citations

Isotretinoin Treatment of Severe Acne Affects the Endogenous Concentration of Vitamin A in Sebaceous Glands

1990 • 18 citations

Metabolism of isotretinoin. Biliary excretion of isotretinoin glucuronide in the rat.

1986 • 17 citations

Oral acitretin in psoriasis: drug and vitamin A concentrations in plasma, skin and adipose tissue.

1992 • 17 citations

Serum concentrations of retinol, d-α-tocopherol and β-carotene: effects of storage at —70°C for five years

1993 • 17 citations

Tear secretion and lacrimal gland function of rabbits treated with isotretinoin

1988 • 17 citations

Targeted slow-release of retinoids into chick embryos

1990 • 17 citations

Identification of 11-cis-retinal and demonstration of its light-induced isomerization in the chicken pineal gland

1991 • 17 citations

Analysis of high dysmorphogenic activity of Ro 13‐6307, a tetramethylated tetralin analog of retinoic acid

1992 • 17 citations

HPLC, MS, and Pharmacokinetics of Melphalan, Bisantrene and 13-cis Retinoic Acid

1982 • 17 citations

Micronutrient Assay for Cancer Prevention Clinical Trials: Serum Retinol, Retinyl Palmitate, Alpha-Carotene, and Beta-Carotene With the Use of High-Performance Liquid Chromatography<xref ref-type="fn" rid="FN2">2</xref>

1987 • 16 citations

Electrochemical Detection of Retinoids Using Normal Phase HPLC

1991 • 16 citations

A direct microassay for serum retinol (vitamin A alcohol) by using size-exclusion high-pressure liquid chromatography with fluorescence detection

1988 • 16 citations

Serum concentrations of retinol, d-alpha-tocopherol and beta-carotene: effects of storage at -70 degrees C for five years.

1993 • 16 citations

Determination of retinyl palmitate and total vitamin A content in liver and liver-based ready-to-eat foods

1992 • 16 citations

Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all-trans-retinamide, the major metabolite of N-(4-hydroxyphenyl)-all-trans-retinamide, in female mice.

1990 • 16 citations

Separation of retinoic acid all-trans, mono-cis and poly-cis isomers by reversed-phase high-performance liquid chromatography

1993 • 16 citations

Ultra-sensitive coupled-column liquid chromatographic determination of retinoids by direct injection of large plasma volumes and ultraviolet detection

1990 • 16 citations

Rapid high-performance liquid chromatographic analysis of retinal mixtures

1986 • 15 citations

High-Performance Liquid Chromatography of Vitamin A Compounds

1988 • 15 citations

Improved and Rapid High-Performance Liquid Chromatographic Assay for 13-cis- Retinoic Acid or All-trans-retinoic Acid

1982 • 15 citations

Vitamin a is stored as fatty acyl esters of retinol in the lacrimal gland

1988 • 15 citations

Separation of isomeric compounds by reversed-phase high-performance liquid chromatography using Ag+ complexation

1993 • 15 citations

Pharmacokinetics, tissue distribution and placental permeability of tetrahydro-tetramethyl-naphthalenyl-propenyl benzoic acid (a retinoidal benzoic acid derivative) in hamsters

1989 • 15 citations

Retinoids and carotenoids in bovine pineal gland

1991 • 15 citations

Glucuronidation of all-trans-retinoic acid in liposomal membranes

1993 • 15 citations

High-performance liquid chromatographic determination of etretinate and all- trans- and 13- cis-acitretin in human plasma

1990 • 15 citations

[5] High-performance liquid chromatography of retinoid isomers: An overview

1990 • 14 citations

Biotransformation of etretinate and developmental toxicity of etretin and other aromatic retinoids in teratogenesis bioassays.

1989 • 14 citations

Bioanalytical application of multidimensional open tubular column supercritical fluid chromatography

1993 • 14 citations

[14] Determination of retinoids in plasma by high-performance liquid chromatography and automated column switching

1990 • 14 citations

Determination of the aromatic retinoids (etretin and isoetretin) in biological fluids by high-performance liquid chromatography

1987 • 14 citations

Skin, adipose tissue and plasma levels of acitretin with rare occurrence of esterified acitretin during long/term treatment.

1993 • 14 citations

Retinoids

1993 • 13 citations

The Reversed-Phase HPLC Behavior of Retinyl Esters

1989 • 13 citations

Concurrent analysis of plasma retinol and alpha-tocopherol by isocratic HPLC.

1990 • 13 citations

Quantification of acitretin in human plasma by microbore liquid chromatography—negative chemical ionization mass spectrometry

1991 • 13 citations

Use of stop-flow oxalate ester chemiluminescence as a means to determine conditions for high-performance liquid chromatography chemiluminescence detection of retinoids using normal-phase chromatography

1991 • 13 citations

Intramuscular Relative Dose Response (RDR) Determination of Liver Vitamin A Stores in Rats

1991 • 12 citations

Systemic pharmacokinetics of acetylenic retinoids in rats.

1990 • 12 citations

Etretinate Blood Levels in Monitoring of Compliance and Contamination in a Chemoprevention Trial

1989 • 12 citations

[2] Synthetic retinoic acid analogs: handling and characterization

1990 • 12 citations

[6] Quantitative analysis of retinal and 3-dehydroretinal by high-pressure liquid chromatography

1986 • 12 citations

Adaptation of a Carotenoid Procedure to Analyze Carotenoids, Retinol, and Alpha-Tocopherol Simultaneously

1994 • 12 citations

[61] Retinoic acid formation from retinol and retinal metabolism in epidermal cells

1990 • 12 citations

Determination of Acitretin and 13<i>-cis-</i>Acitretin in Skin

1989 • 12 citations

Simple reversed-phase high-performance liquid chromatographic method for 13-cis-retinoic acid in serum

1992 • 11 citations

Nonaqueous reversed-phase liquid chromatography and fluorimetry compared for determination of retinol in serum.

1983 • 11 citations

Identification of etretinate metabolites in human bile.

1989 • 11 citations

Simultaneous microassay for etretinate and its active metabolite, etretin, by reversed-phase high-performance liquid chromatography

1988 • 11 citations

Determination of the new aromatic retinoic acid Ro 13-7410 in plasma by two-dimensional gas chromatography negative ion chemical ionization mass spectrometry with selected-ion monitoring

1989 • 11 citations

Rapid Determination of Acitretin or Isotretinoin and Their Major Metabolites by High-Performance Liquid Chromatography

1988 • 11 citations

Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching

1992 • 11 citations

Separation of retinoic acid isomers using micellar electrokinetic chromatography

1993 • 10 citations

Glutathione Catalysis of lnterconversion of Acitretin and Its 13-cis Isomer lsoacitretin

1990 • 10 citations

Disposition of [14C]acitretin in humans following oral administration.

1994 • 10 citations

[9] Stable isotope dilution mass spectrometry to assess vitamin a status

1990 • 10 citations

Conceptal biotransformation of 4-oxo-all-tranas-retinoic acid, 4-oxo-13-cis-retinoic acid and all-tranas-retinoyl-β-glucuronide in rat whole embryo culture

1992 • 10 citations

The metabolism of acitretin and isoacitretin in the in situ isolated perfused rat liver

1992 • 10 citations

[60] Metabolism of retinoic acid and retinol by intact cells and cell extracts

1990 • 10 citations

[10] Mass spectrometry of methyl ester of retinoic acid

1990 • 9 citations

Improved quantitation of 13-cis- and all-trans-acitretin in human plasma by normal-phase high-performance liquid chromatography

1991 • 9 citations

Effect of end-capping of reversed-phase high-performance liquid chromatographic matrices on the analysis of vitamin A and its metabolites

1986 • 9 citations

The pharmacokinetics of etretinate and its metabolites in the dog.

1989 • 9 citations

A New Pathway for Vitamin A

1992 • 9 citations

Endogenous levels of β-carotene in human buccal mucosa cells by reversed-phase high-performance liquid chromatography

1990 • 9 citations

[4] High-performance liquid chromatography of retinoids in blood

1990 • 9 citations

A road less travelled: Normal phase microbore liquid chromatography—mass spectrometry using direct liquid introduction

1991 • 8 citations

Fatty acid composition and kinetic behaviour of liver retinyl esters in vitamin A sufficient and deficient rats

1988 • 8 citations

Capillary gas chromatography of retinoids (vitamin A compounds) and apo-retinoids: determination of Kováts retention indices

1990 • 8 citations

UV-induced isomerization of oral retinoids in vitro and in vivo in hairless mice.

1990 • 8 citations

Die Chemie des Vitamins A und des Sehvorgangs

1990 • 7 citations

Retinamides: Hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity

1992 • 7 citations

High-performance liquid chromatography determination of acitretin in plasma and its application to a pharmacokinetic study in human subjects.

1992 • 7 citations

Pharmacokinetics of ¹⁴C‐etretinate in healthy volunteers and two patients with biliary t‐tube drainage

1988 • 6 citations

Biosynthesis of 3,4-didehydroretinol and fatty acyl esters of retinol and 3,4-didehydroretinol by organ-cultured human skin

1990 • 6 citations

Determination of the retinoid (E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethenyl)naphthalene and its phenolic metabolite in human plasma by reversed-phase high-performance liquid chromatography

1991 • 6 citations

Analysis of retinoids by direct exposure probe mass spectrometry

1988 • 6 citations

Replacement of toxic mobile phases commonly used in high performance liquid chromatography of retinoids

1994 • 6 citations

Identification of 3-dehydroretinol (vitamin A2) in mouse liver

1988 • 6 citations

Determination of (E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethenyl) naphthalene, an antiacne agent, and its phenolic metabolite in plasma by reversed-phase high-performance liquid chromatography

1987 • 6 citations

The metabolic fate of 13-cis-retinoic acid in mouse skin microsomal preparations.

1990 • 6 citations

The distribution of cis‐ and trans‐acitretin in human epidermis.

1992 • 5 citations

[7] Separation of fatty acid esters of retinol by high-performance liquid chromatography

1990 • 5 citations

13-Cis Retinoyl-β-Glucuronide in Lacrimal Gland Fluid of Rabbits Treated with 13-Cis Retinoic Acid

1990 • 5 citations

Influence of pregnancy on the pharmacokinetic disposition of two aromatic retinoids (etretinate and acitretin) in the rat. II. Single and multiple oral dosing studies.

1989 • 4 citations

Aspects of the capillary GC analysis of all‐trans‐ and 13‐cis‐acitretin

1992 • 3 citations

Retinoids and Related Compounds. Part 12. Optical Resolution of(.+-.)-All-trans-3-Hydroxyretinal by Use of High-Performance Liquid Chromatography.

1992 • 3 citations

[16] High-performance liquid chromatography of aromatic retinoids and isotretinoin in biological fluids

1990 • 3 citations

Concentrations of Isotretinoin and the Arotinoid Ro 15-0778 in Plasma and Tissues of Hamsters and Rats

1988 • 3 citations

Therapeutic Drug Monitoring of Retinoids

1992 • 2 citations

Purity Determination by a Combination of Spectrophotometric and Liquid Chromatographic Methods: Application to 13-cis-Retinoic Acid

1990 • 2 citations

Influence of pregnancy on the pharmacokinetic disposition of two aromatic retinoids (etretinate and acitretin) in the rat. I. Intravenous studies.

1989 • 2 citations

A phase 1 and pharmacokinetic study using the aromatic retinoic acid analogue dichloroetretinate (Ro 12-7554)

1990 • 2 citations

Determination of Arotinoid Ro 15–0778 and its Metabolite in Plasma by HPLC

1991 • 1 citations

Concentration of Temarotene (Ro 15-0778) and Its Metabolite Ro 14-6113 in Plasma and Skin of Hairless Rat

1993 • 1 citations

Development of a simple method for the determination of serum vitamin A level as reflector of nutritional status.

1987 • 1 citations

Morphological and biochemical alterations in growing rats induced by etretinate.

1989 • 1 citations

[54] Retinol 4-hydroxylase

1990 • 1 citations