Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: Comparison to the all-trans isomer

Retinoic Acid Embryopathy

1985 • 1,921 citations

Vitamin A congeners

1986 • 369 citations

VITAMIN A AND RETINOIDS: FROM NUTRITION TO PHARMACOTHERAPY IN DERMATOLOGY AND ONCOLOGY

1983 • 218 citations

VAGINAL THRUSH

1962 • 164 citations

Changes in levels of cellular retinol- and retinoic-acid-binding proteins of liver and lung during perinatal development of rat.

1976 • 154 citations

The Village of Aro

1964 • 149 citations

Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo

1986 • 131 citations

Comparative teratogenic activities of two retinoids: Effects on palate and limb development

1984 • 114 citations

FROM VITAMIN A TO RETINOIDS IN EXPERIMENTAL AND CLINICAL ONCOLOGY: ACHIEVEMENTS, FAILURES, AND OUTLOOK

1981 • 110 citations

Pharmacokinetics of isotretinoin during repetitive dosing to patients

1983 • 108 citations

Cellular Vitamin A Binding Proteins

1979 • 107 citations

Isotretinoin teratogenicity in mouse whole embryo culture.

1986 • 83 citations

Dose-dependent kinetics of all-trams-retinoic acid in rats

1981 • 73 citations

Systemic Mode of Action of Vitamin A

1981 • 67 citations

Pharmacokinetics in teratogenesis

1986 • 66 citations

Disposition of all-trans-retinoic acid in mice following oral doses.

1981 • 53 citations

Disposition of all-trans- and 13-cis-retinoic acids and n-hydroxyethylretinamide in mice after intravenous administration.

1980 • 51 citations

Cellular retinoid binding proteins

1985 • 49 citations

Automated Determination of 13-Cis-and All-Trans-Retinoic Acid, Their 4-Oxo-Metabolites and Retinol in Plasma, Amniotic Fluid and Embryo by Reversed-Phase High-Performance Liquid Chromatography with a Precolumn Switching Technique

1988 • 45 citations

Identification of the cellular retinoic acid binding protein (cRABP) within the embryonic mouse (CD‐1) limb bud

1985 • 41 citations

Cellular Retinoic Acid-Binding Proteins in Human Epidermis and Sebaceous Follicles

1984 • 36 citations

Disposition of 13-cis-retinoic acid and N-(2-hydroxyethyl)retinamide in mice after oral doses.

1982 • 35 citations

Automated High-Pressure Liquid Chromatographic Assay for Antiepileptic Drugs and Their Major Metabolites by Direct Injection of Serum Samples

1984 • 30 citations