Column-switching techniques for high-performance liquid chromatography of drugs in biological samples

Sensitive high-performance liquid chromatographic determination of ionic drugs in biological fluids with short-wavelength ultraviolet detection using column switching combined with ion-pair chromatography: application to basic compounds

1989 • 282 citations

Fully automated high-performance liquid chromatography

1981 • 200 citations

Some characteristics of a protein-coated ODS column and its use for the determination of drugs by the direct injection analysis of plasma samples

1984 • 95 citations

Monitoring of veterinary drug residues by a combination of continuous flow techniques and column-switching high-performance liquid chromatography

1988 • 90 citations

Direct injection of plasma into column liquid chromatographic systems

1987 • 89 citations

Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching

1988 • 79 citations

Systematic approach to column switching

1988 • 74 citations

On-line combination of dialysis and column-switching liquid chromatography as a fully automated sample preparation technique for biological samples

1990 • 71 citations

Automated on-line multi-dimensional high-performance liquid chromatographic techniques for the clean-up and analysis of water-soluble samples

1981 • 71 citations

Review: ultraselectivity through column switching and mode sequencing in liquid chromatography

1981 • 69 citations

Automated liquid chromatographic analysis of drugs in urine by on-line sample cleanup and isocratic multi-column separation

1989 • 68 citations

Application of column switching in high-performance liquid chromatography to on-line sample preparation for complex separations

1981 • 67 citations

Determination of β-19-nortestosterone and its metabolite α-19-nortestosterone in biological samples at the sub parts per billion level by high-performance liquid chromatography with on-line immunoaffinity sample pretreatment

1989 • 65 citations

Fully automated sample handling system for liquid chromatography based on pre-column technology and automated cartridge exchange

1987 • 63 citations

Routine determination of eight common anti-epileptic drugs and metabolites by high-performance liquid chromatography using a column-switching system for direct injection of serum samples

1984 • 62 citations

Determination of ofloxacin in human serum by high-performance liquid chromatography with column switching

1992 • 60 citations

Review of Drug Analysis with Direct Serum Injection on the HPLC Column

1988 • 59 citations

Rapid determination of clenbuterol residues in urine by high-performance liquid chromatography with on-line automated sample processing using immunoaffinity chromatography

1990 • 56 citations

A simple high-performance liquid chromatographic pre-column technique for investigation of drug metabolism in biological fluids

1982 • 56 citations

Optimization of precolumn design in liquid chromatography

1984 • 52 citations

Boxcar chromatography

1981 • 50 citations

Applications of a microprocessor-controlled valve-switching unit for automated sample cleanup and trace enrichment in high-performance liqud chromatography

1983 • 47 citations

Coupled-column chromatography on immobilized protein phases for direct separation and determination of drug qenantiomers in plasma

1989 • 47 citations

Procedures for direct injections of untreated blood plasma into liquid chromatographic columns with emphasis on a pre-column venting technique

1984 • 46 citations

Drug Monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma

1986 • 46 citations

Automated analysis of antiepileptic drugs in serum by column-switching high-performance liquid chromatography

1984 • 46 citations

Precolumns of Amberlite XAD-2 for direct injection liquid chromatographic determination of methaqualone in blood plasma

1982 • 46 citations

Automated pre-column system for trace enrichment and clean-up of plasma samples in narrow-bore liquid chromatography

1985 • 45 citations

Determination of drug substances in biological fluids by direct injection multidimensional liquid chromatography with a micellar cleanup and reversed-phase chromatography

1988 • 44 citations

Determination of tryptophan and its metabolites in human plasma and serum by high-performance liquid chromatography with automated sample clean-up system

1990 • 43 citations

Determination of highly protein bound in plasma using high-performance liquid chromatography and column switching, exemplified by the retinoids

1988 • 41 citations

Improvements in automated analysis of catecholamine and related metabolites in biological samples by column-switching high-performance liquid chromatography

1991 • 40 citations

Application of micellar mobile phases for the assay of drugs in biological fluids

1990 • 39 citations

Coupled column chromatography—mass spectrometry

1989 • 39 citations

Immunoaffinity precolumn for selective sample pretreatment in column liquid chromatography: Immunoselective desorption

1991 • 35 citations

Automated determination of orotic acid, uracil and pseudouridine in urine by high-performance liquid chromatography with column switching

1991 • 34 citations

Influence for solute polarity in column-switching chromatography for the assay of drugs in plasma and urine

1984 • 32 citations

Automated determination of drugs in serum by column-switching high-performance liquid chromatography. IV. Separation of tricyclic and tetracyclic antidepressants and their metabolites.

1989 • 29 citations

Column-switching high-performance liquid chromatography for on-line simultaneous determination and resolution of enantiomers of verapamil and its metabolites.

1991 • 28 citations

Phase-system switching: A new approach in liquid chromatography/mass spectrometry coupling

1988 • 27 citations

Automated determination of drugs in serum by columnswitching high-performance liquid chromatography II. Separation of theophylline and its metabolites

1988 • 26 citations

9-Fluoreneacetyl-tagged, solid-phase reagent for derivatization in direct plasma injection

1992 • 26 citations

Determination of anticonvulsant drugs and methyl xanthine derivatives in serum by liquid chromatography with direct injection: column-switching method using a new internal-surface reversed-phase silica support as a precolumn

1990 • 26 citations

Use of enzymatic solubilization of tissues and direct injection of pre-columns of large volumes for analysing biological samples by high-performance liquid chromatography

1986 • 26 citations

Liquid chromatography-mass spectrometry system using column-switching techniques

1991 • 24 citations

Automation of liquid chromatographic techniques for biomedical analysis

1989 • 23 citations

Determination of residues of carbadox and some of its metabolites in swine tissues by high-performance liquid chromatography using on-line pre-column enrichment and post-column derivatization with UV—VIS detection

1988 • 23 citations

Simultaneous quantification of zidovudine and its metabolites in serum and urine by high-performance liquid chromatography using a column-switching technique

1990 • 23 citations

Column-switching techniques for high-performance liquid chromatography of ibuprofen and mefenamic acid in human serum with short-wavelength ultraviolet detection

1991 • 23 citations

High-performance liquid chromatographic determination of phenylpropanolamine in human plasma and urine, using column switching combined with ion-pair chromatography

1990 • 20 citations

On-Line Sample Enrichment and Cleanup for High Performance Liquid Chromatography with Column Switching Technique A Review

1989 • 20 citations

Determination of S-carboxymethylcysteine in serum by reversed-phase ion-pair liquid chromatography with column switching following pre-column derivatization with o-phthalaldehyde

1988 • 20 citations

Full automation of catecholamine metabolite determination by column switching and high-performance liquid chromatography

1989 • 19 citations

Automated reversed-phase chromatographic analysis of etoposide and teniposide in plasma by using on-line surfactant-mediated sample clean-up and column-switching

1989 • 19 citations

Coupled column chromatography in chiral separations: systems employing β-eyclodextrin phases for chiral separation

1991 • 18 citations

High-performance liquid chromatographic determination of rifapentine in serum using column switching

1992 • 17 citations

Direct analysis of the dopamine agonist (−)-2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin hydrochloride in plasma by high-performance liquid chromatography using two-dimensional column switching

1991 • 17 citations

Measurement of urinary catecholamines and their catechol metabolites and precursor by liquid chromatography with column-switching and on-line fluorimetric and electrochemical detection

1985 • 16 citations

Optimization of multidimensional high-performance liquid chromatography for the determination of drugs in plasma by direct injection, micellar cleanup and photodiode array detection

1990 • 16 citations

Application of column switching in high-performance liquid chromatographic analysis of medroxalol in plasma

1987 • 13 citations

Determination of a new non-benzodiazepine anxiolytic and its O-demethyl metabolite in plasma by high-performance liquid chromatography using automated column-switching

1988 • 12 citations

Sensitive high-performance liquid chromatographic determination of propranolol in human plasma with ultraviolet detection using column switching combined with ion-pair chromatography

1990 • 12 citations

Determination of Ketoprofen Enantiomers in Plasma by Solid Phase Extraction and Column Switching High Performance Liquid Chromatography

1991 • 12 citations

Simultaneous determination of a new gastrointestinal prokinetic agent (HSR-803) and its metabolites in human serum and urine by high-performance liquid chromatography using automated column-switching

1992 • 12 citations

Selective on-line trace enrichment for the determination of ethynyl steroids in urine by liquid chromatography with precolumn technology

1987 • 11 citations

Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching

1992 • 11 citations

Determination of oxiracetam in plasma and urine by column-switching high-performance liquid chromatography

1989 • 11 citations

High-performance liquid chromatographic determination of adriblastin in human plasma, urine, saliva and liver punctuate by column switching for drug monitoring studies

1988 • 9 citations

Automated determination of disopyramide and N-monodealkyldisopyramide in plasma by reversed-phase liquid chromatography with a column switching system

1992 • 8 citations

Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism

1992 • 8 citations

Determination of amifloxacin and two of its principal metabolites in plasma and urine by high-performance liquid chromatography using automated column switching

1990 • 8 citations

Direct injection of highly protein-bound compounds by column-switching high-performance liquid chromatography

1990 • 7 citations

Increased Flexibility in Multicolumn Chromatography (MC[sbnd]HPLC) via On-line Effluent Mixing Technique

1987 • 7 citations

Determination of a new dihydropyridine derivative, methyl 3-cyclopentyl-4,7-dihydro-1,6-dimethyl-4-(3-nitrophenyl)pyrazolo[3,4-b] pyridine-5-carboxylate, in human serum by high-performance liquid chromatography with electrochemical detection and column switching

1986 • 6 citations

Determination of Clocapramine and Its Metabolites in Plasma by Automated Column-Switching High Performance Liquid Chromatography

1990 • 4 citations

Analysis of drug in tissue homogenates by high performance liquid chromatography with direct injection and column switching

1989 • 4 citations

Column liquid chromatographic determination of prajmalium in plasma and urine by direct sample injection

1987 • 4 citations

Determination of cicletanine in human plasma by high-performance liquid chromatography using automated column switching

1992 • 4 citations

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