Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Role of amino acid transport and countertransport in nutrition and metabolism.

1990 • 1,101 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

Synthesis of the translational apparatus is regulated at the translational level

2000 • 515 citations

<scp>l</scp> -Amino acid sensing by the extracellular Ca ²⁺ -sensing receptor

2000 • 484 citations

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

1995 • 455 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

1988 • 449 citations

Regulation of the p70 S6 Kinase by Phosphorylation in Vivo

1998 • 375 citations

The TOR Kinases Link Nutrient Sensing to Cell Growth

2001 • 348 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 331 citations

The Principal Rapamycin-Sensitive p70^s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

1996 • 245 citations

Amino Acid-dependent Control of p70s6k

1999 • 205 citations

Genetic and Biochemical Analysis of the Yeast Plasma Membrane Ssy1p-Ptr3p-Ssy5p Sensor of Extracellular Amino Acids

2001 • 151 citations

Amino-acid-dependent signal transduction

2000 • 132 citations

Control of Initiation of Protein Synthesis in Human Cells

1973 • 129 citations

Regulation by nutrient limitation

1999 • 122 citations

Regulation of Glycogen Synthesis by Amino Acids in Cultured Human Muscle Cells

2001 • 117 citations

Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells

2000 • 108 citations

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

2001 • 105 citations

Structural requirement of leucine for activation of p70 S6 kinase

1999 • 98 citations

Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes

2001 • 83 citations

Amino-acid-dependent signal transduction

2000 • 79 citations

Nutrients differentially regulate multiple translation factors and their control by insulin

1999 • 78 citations

Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in Xenopus oocytes

1999 • 66 citations

p70^S6K Controls Selective mRNA Translation during Oocyte Maturation and Early Embryogenesis in Xenopus laevis

1999 • 60 citations

Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable derivative of the multiple antigen peptide Leu8-Lys4-Lys2-Lys-beta Ala.

1994 • 59 citations

Biomembrane Transport

1999 • 51 citations

Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

2000 • 37 citations

Amino-Acid-Dependent Modulation of Amino Acid Transport in Xenopus Laevis Oocytes

1996 • 33 citations

Regulation of amino acid transporters by amino acid availability

2001 • 22 citations

Multiple components of arginine and phenylalanine transport induced in neutral and basic amino acid transporter-cRNA-injected Xenopus oocytes

1996 • 20 citations

Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

2000 • 20 citations

Interactions between the thiol-group reagent N-ethylmaleimide and neutral and basic amino acid transporter-related amino acid transport

1999 • 17 citations

Biomembrane Transport and Interorgan Nutrient Flows

1999 • 14 citations