Physical and Conformational Properties of Synthetic Idealized Signal Sequences Parallel Their Biological Function

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Computed circular dichroism spectra for the evaluation of protein conformation

1969 • 3,654 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

A MODIFIED NINHYDRIN REAGENT FOR THE PHOTOMETRIC DETERMINATION OF AMINO ACIDS AND RELATED COMPOUNDS

1954 • 3,024 citations

Culture Medium for Enterobacteria

1974 • 3,002 citations

Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

1974 • 2,173 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

The Ultraviolet Circular Dichroism of Polypeptides¹

1965 • 1,013 citations

Correlation of competence for export with lack of tertiary structure of the mature species: A study in vivo of maltose-binding protein in E. coli

1986 • 473 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

1990 • 455 citations

Intrinsic secondary structure propensities of the amino acids, using statistical ϕ–ψ matrices: Comparison with experimental scales

1994 • 294 citations

Side-chain entropy opposes alpha-helix formation but rationalizes experimentally determined helix-forming propensities.

1992 • 281 citations

The circular dichroism of the β structure of poly-l-lysine

1966 • 272 citations

Modulation of Folding Pathways of Exported Proteins by the Leader Sequence

1988 • 243 citations

Environment affects amino acid preference for secondary structure.

1992 • 241 citations

Effect of Chain Length on the Formation and Stability of Synthetic .alpha.-Helical Coiled Coils

1994 • 230 citations

Stabilization of alpha-helical structures in short peptides via end capping.

1993 • 229 citations

SecA interacts with secretory proteins by recognizing the positive charge at the amino terminus of the signal peptide in Escherichia coli.

1990 • 229 citations

On the Hydrophobic Nature of Signal Sequences

1981 • 193 citations

Predicted secondary structures of amino‐terminal extension sequences of secreted proteins

1979 • 172 citations

Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments

1993 • 169 citations

Conformational studies of the synthetic precursor-specific region of preproparathyroid hormone.

1980 • 109 citations

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide

1986 • 98 citations

Functional and Nonfunctional LamB Signal Sequences Can Be Distinguished by Their Biophysical Properties

1989 • 97 citations

Anionic phospholipids are essential for .alpha.-helix formation of the signal peptide of prePhoE upon interaction with phospholipid vesicles

1992 • 94 citations

Vacuum ultraviolet circular dichroism of .beta.-forming alkyl oligopeptides

1976 • 87 citations

Analysis of mutational alterations in the hydrophilic segment of the maltose-binding protein signal peptide

1989 • 79 citations

Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function

1991 • 74 citations

Characterization of the interfacial behavior and structure of the signal sequence of Escherichia coli outer membrane pore protein PhoE.

1988 • 72 citations

Functional limits of conformation, hydrophobicity, and steric constraints in prokaryotic signal peptide cleavage regions. Wild type transport by a simple polymeric signal sequence.

1991 • 61 citations

Titration of protein transport activity by incremental changes in signal peptide hydrophobicity

1993 • 58 citations

Comparison of helix stability in wild-type and mutant LamB signal sequences.

1990 • 52 citations

Signal peptide cleavage regions. Functional limits on length and topological implications.

1994 • 45 citations

Conformational requirement of signal sequences functioning in yeast: circular dichroism and proton nuclear magnetic resonance studies of synthetic peptides

1990 • 38 citations

Vacuum ultraviolet circular dichroism of protected homooligomers derived from L-leucine

1977 • 36 citations

Signal peptide hydrophobicity is finely tailored for function

1994 • 30 citations