Eating disorders, gene–environment interactions and epigenetics

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Epigenetic programming by maternal behavior

2004 • 5,974 citations

Human DNA methylomes at base resolution show widespread epigenomic differences

2009 • 4,388 citations

The Structured Clinical Interview for DSM-III-R (SCID)

1992 • 4,294 citations

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

2007 • 4,239 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Epigenetic differences arise during the lifetime of monozygotic twins

2005 • 3,451 citations

Persistent epigenetic differences associated with prenatal exposure to famine in humans

2008 • 2,912 citations

Risk and maintenance factors for eating pathology: A meta-analytic review.

2002 • 2,295 citations

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

2006 • 1,997 citations

Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming

2005 • 1,872 citations

Living with the Past: Evolution, Development, and Patterns of Disease

2004 • 1,804 citations

Bulimia nervosa: an ominous variant of anorexia nervosa

1979 • 1,760 citations

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

2006 • 1,724 citations

The Developmental Origins of Adult Disease

2004 • 1,678 citations

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

2007 • 1,674 citations

The Obesity-AssociatedFTOGene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

2007 • 1,425 citations

Coming to Terms With Risk Factors for Eating Disorders: Application of Risk Terminology and Suggestions for a General Taxonomy.

2004 • 1,403 citations

Epigenetic regulation in psychiatric disorders

2007 • 1,357 citations

Role of body dissatisfaction in the onset and maintenance of eating pathology

2002 • 1,321 citations

Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why?

2007 • 1,303 citations

Gene–environment interactions in psychiatry: joining forces with neuroscience

2006 • 1,263 citations

Preventing the return of fear in humans using reconsolidation update mechanisms

2009 • 1,176 citations

Childhood maltreatment predicts adult inflammation in a life-course study

2007 • 1,153 citations

The Human Obesity Gene Map: The 2005 Update

2006 • 1,148 citations

Inherited epigenetic variation — revisiting soft inheritance

2006 • 1,126 citations

Sex-specific, male-line transgenerational responses in humans

2005 • 1,125 citations

How can drug addiction help us understand obesity?

2005 • 1,065 citations

Two classes of short interfering RNA in RNA silencing

2002 • 1,022 citations

Timing of Pubertal Maturation in Girls: An Integrated Life History Approach.

2004 • 967 citations

Risk factors for eating disorders.

2007 • 965 citations

Inactivation of the Fto gene protects from obesity

2009 • 911 citations

Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

2005 • 904 citations

Epigenetic Epidemiology of the Developmental Origins Hypothesis

2007 • 833 citations

Beyond extinction: erasing human fear responses and preventing the return of fear

2009 • 792 citations

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases

2003 • 788 citations

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

2002 • 782 citations

New insights into symptoms and neurocircuit function of anorexia nervosa

2009 • 764 citations

Epigenetic mechanisms and the transgenerational effects of maternal care

2008 • 761 citations

Binge eating disorder: Its further validation in a multisite study

1993 • 755 citations

Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment

2008 • 750 citations

Risk Factors for Bulimia Nervosa

1997 • 741 citations

Epigenetic mechanisms in memory formation

2005 • 739 citations

Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology

2007 • 715 citations

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

2008 • 687 citations

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

2010 • 680 citations

Putative contributors to the secular increase in obesity: exploring the roads less traveled

2006 • 631 citations

Leptin Regulates Striatal Regions and Human Eating Behavior

2007 • 608 citations

Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?

2004 • 533 citations

Are eating disorders culture-bound syndromes? Implications for conceptualizing their etiology.

2003 • 508 citations

Transgenerational response to nutrition, early life circumstances and longevity

2007 • 497 citations

Metastable epialleles in mammals

2002 • 496 citations

A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

2008 • 494 citations

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

2010 • 475 citations

Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation

2007 • 474 citations

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

2007 • 465 citations

Psychological and Behavioral Risk Factors for Obesity Onset in Adolescent Girls: A Prospective Study.

2005 • 444 citations

Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

2002 • 442 citations

Prenatal Exposure to Wartime Famine and Development of Antisocial Personality Disorder in Early Adulthood

1999 • 425 citations

Modulation of Brain Reward Circuitry by Leptin

2000 • 411 citations

The co‐morbidity of eating disorders and anxiety disorders: a review

2007 • 407 citations

Epigenetics at the Epicenter of Modern Medicine

2008 • 405 citations

Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat

1992 • 404 citations

Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO

2008 • 404 citations

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

2008 • 402 citations

Evolution, development and timing of puberty

2005 • 401 citations

Genomic imprinting effects on brain development and function

2007 • 374 citations

Further Evidence of Relation Between Prenatal Famine and Major Affective Disorder

2000 • 366 citations

Time trends in eating disorder incidence

2005 • 364 citations

Prevention of obesity and eating disorders: a consideration of shared risk factors

2006 • 359 citations

The genetics of obesity: FTO leads the way

2010 • 350 citations

Low-Dose Cortisol for Symptoms of Posttraumatic Stress Disorder

2004 • 336 citations

Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring

2010 • 335 citations

Fat and bone

2010 • 334 citations

Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome

2002 • 328 citations

Eating Disorder Behaviors Are Increasing: Findings from Two Sequential Community Surveys in South Australia

2008 • 323 citations

Leptin: Structure, Function and Biology

2005 • 323 citations

Leptin in reproduction

2001 • 309 citations

Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes

2003 • 303 citations

The effect of finite periods of undernutrition at different ages on the composition and subsequent development of the rat

1963 • 301 citations

Neurobiology of early life stress: Clinical studies

2002 • 300 citations

Genetic Epidemiology of Obesity

2007 • 300 citations

Brain function and chromatin plasticity

2010 • 298 citations

Molecular studies of major depressive disorder: the epigenetic perspective

2007 • 295 citations

Adolescent-onset anorexia nervosa: 18-year outcome

2009 • 276 citations

Impact of Folate Deficiency on DNA Stability

2002 • 274 citations

A neurodevelopmental model for anorexia nervosa

2003 • 257 citations

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

2006 • 251 citations

Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia

2003 • 247 citations

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?

2008 • 243 citations

The Dutch Famine and schizophrenia spectrum disorders

1998 • 238 citations

Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction

2007 • 238 citations

Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile

2008 • 238 citations

Membrane-Associated Glucocorticoid Activity Is Necessary for Modulation of Long-Term Memory via Chromatin Modification

2010 • 234 citations

Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

2009 • 229 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis

1997 • 223 citations

Recovery and chronicity in anorexia nervosa

2003 • 212 citations

Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats

2004 • 209 citations

Pre‐ and peri‐natal environmental risks for attention‐deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility

2008 • 208 citations

Stress, Hypothalamic-Pituitary-Adrenal Axis and Eating Disorders

2008 • 201 citations

The eating disorders as addiction

1998 • 197 citations

Fetal programming: link between early nutrition, DNA methylation, and complex diseases

2010 • 196 citations

The pattern of maternal weight gain in women with good pregnancy outcomes.

1997 • 194 citations

Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety

2008 • 192 citations

Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the dutch famine

2006 • 187 citations

The role of genetic variation in the causation of mental illness: an evolution-informed framework

2009 • 183 citations

Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response

2006 • 183 citations

Risk of major adverse perinatal outcomes in women with eating disorders

2007 • 183 citations

Fetal Growth and the Adrenocortical Response to Psychological Stress

2006 • 177 citations

Patterns of remission, continuation and incidence of broadly defined eating disorders during early pregnancy in the Norwegian Mother and Child Cohort Study (MoBa)

2007 • 175 citations

Repetitive Transcranial Magnetic Stimulation Reduces Cue-Induced Food Craving in Bulimic Disorders

2010 • 163 citations

An investigation of decision making in anorexia nervosa using the Iowa Gambling Task and skin conductance measurements

2007 • 163 citations

Maternal nutrition during gestation and blood pressure in later life

2001 • 162 citations

Association of the FTO Gene With BMI

2008 • 161 citations

Eating disorders symptoms in pregnancy: A longitudinal study of women with recent and past eating disorders and obesity

2007 • 161 citations

Is there a specific trauma precipitating anorexia nervosa?

1997 • 161 citations

Neuropsychological studies in anorexia nervosa

2005 • 155 citations

Epigenetic dysregulation of dopaminergic genes in eating disorders

2009 • 155 citations

Pathologic fear conditioning and anorexia nervosa: On the search for novel paradigms

2004 • 153 citations

The association of anxiety disorders and obsessive compulsive personality disorder with anorexia nervosa: Evidence from a family study with discussion of nosological and neurodevelopmental implications

2007 • 152 citations

Brief Undernutrition in Late-Gestation Sheep Programs the Hypothalamic-Pituitary-Adrenal Axis in Adult Offspring

2003 • 148 citations

The Genetics of Anorexia Nervosa

2007 • 145 citations

Birth weight is associated with salivary cortisol responses to psychosocial stress in adult life

2005 • 142 citations

Pregnancy: Outcome and impact on symptomatology in a cohort of eating-disordered women

2000 • 141 citations

Programming of the stress response: a fundamental mechanism underlying the long‐term effects of the fetal environment?

2007 • 141 citations

Regulation of chromatin structure in memory formation

2009 • 137 citations

Neural correlates of body dissatisfaction in anorexia nervosa

2010 • 136 citations

Enhancing exposure-based therapy from a translational research perspective

2007 • 135 citations

Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats

2005 • 135 citations

Toward an understanding of risk factors for binge-eating disorder in black and white women: a community-based case-control study

2005 • 133 citations

Enhancing exposure therapy for anxiety disorders with glucocorticoids: From basic mechanisms of emotional learning to clinical applications

2009 • 127 citations

Stress response and binge eating disorder

2005 • 125 citations

Links between eating disorder symptom severity and psychiatric comorbidity

2006 • 123 citations

The rising prevalence of comorbid obesity and eating disorder behaviors from 1995 to 2005

2008 • 122 citations

Fetal and perinatal consequences of maternal obesity

2010 • 119 citations

Eating disorder that was diagnosed before pregnancy and pregnancy outcome

2004 • 118 citations

HPA axis programming by maternal undernutrition in the male rat offspring

2007 • 117 citations

Prenatal Hormone Exposure and Risk for Eating Disorders

2008 • 116 citations

Human Leptin: An Adipocyte Hormone with Weight-Regulatory and Endocrine Functions

2005 • 108 citations

The prevalence of eating disorders in infertile women

2008 • 107 citations

Gene–environment interactions and obesity—Further aspects of genomewide association studies

2009 • 107 citations

Hypothalamic leptin regulation of energy homeostasis and glucose metabolism

2007 • 106 citations

Prenatal exposure to the 1944–45 Dutch ‘hunger winter’ and addiction later in life

2008 • 105 citations

Toward an understanding of risk factors for anorexia nervosa: a case-control study

2007 • 104 citations

Environmental and Genetic Risk Factors for Eating Disorders: What the Clinician Needs to Know

2008 • 103 citations

Infertility and eating disorders

1991 • 99 citations

In Vivo Methylation Patterns of the Leptin Promoter in Human and Mouse

2006 • 96 citations

The evolving functions of DNA methylation

2008 • 92 citations

Influence of overanxious disorder of childhood on the expression of anorexia nervosa

2008 • 92 citations

Altered brain‐derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia

2007 • 92 citations

Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa

2010 • 91 citations

The Effects of Stress on Body Weight: Biological and Psychological Predictors of Change in BMI

2007 • 91 citations

One-carbon metabolism in psychiatric illness

2006 • 89 citations

Inappropriate eating behaviors during pregnancy: Prevalence and associated factors among pregnant women attending primary care in southern Brazil

2008 • 88 citations

Birth outcomes and pregnancy complications in women with a history of anorexia nervosa

2006 • 88 citations

Epidemiology of Anorexia Nervosa in Men: A Nationwide Study of Finnish Twins

2009 • 82 citations

Determinants of early ponderal and statural growth in full-term infants in the EDEN mother-child cohort study

2010 • 82 citations

DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence

2010 • 79 citations

Increased reproductive success of women after prenatal undernutrition

2008 • 79 citations

Difference in susceptibility to activity-based anorexia in two inbred strains of mice

2006 • 75 citations

Stress Responsiveness in Adult Life: Influence of Mother’s Diet in Late Pregnancy

2007 • 74 citations

Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients

2008 • 72 citations

Epigenetic Downregulation of Atrial Natriuretic Peptide but not Vasopressin mRNA Expression in Females with Eating Disorders is Related to Impulsivity

2008 • 70 citations

Developmental Changes of Leptin Receptors in Cerebral Microvessels: Unexpected Relation to Leptin Transport

2007 • 70 citations

An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: The role of CRH and AVP

2006 • 70 citations

Eating disorders in pregnancy

2008 • 70 citations

Poor social comparison and the tendency to submissive behavior in anorexia nervosa

2007 • 68 citations

alpha-Melanocyte stimulating hormone: production and degradation

2010 • 67 citations

Nutrient and food group intakes of women with and without bulimia nervosa and binge eating disorder during pregnancy

2008 • 62 citations

Genetic Susceptibility to Eating Disorders: Associated Polymorphisms and Pharmacogenetic Suggestions

2008 • 59 citations

Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver.

1995 • 59 citations

The central nervous system at the core of the regulation of energy homeostasis

2009 • 59 citations

Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine

2006 • 55 citations

Neurophysiology of hunger and satiety

2008 • 53 citations

Binge Eating in Rats Produced by Combining Dieting with Stress

2006 • 52 citations

Fetal Growth, Preterm Birth, Neonatal Stress and Risk for CNS Tumors in Children: A Nordic Population- and Register-Based Case-Control Study

2010 • 48 citations

External influences on the fetus and their long-term consequences

2006 • 45 citations

Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins

2008 • 45 citations

Anorexia and Bulimia Nervosa in Same-Sex and Opposite-Sex Twins: Lack of Association With Twin Type in a Nationwide Study of Finnish Twins

2008 • 44 citations

Role of Epigenetics in Mental Disorders

2008 • 43 citations

Epigenetics, genomic mutations and cognitive function

2009 • 43 citations

Trends in hospital admissions for eating disorders in a country undergoing a socio-cultural transition, the Czech Republic 1981–2005

2009 • 41 citations

Polygenic Contribution to Obesity: Genome-Wide Strategies Reveal New Targets

2008 • 40 citations

Attitudes toward weight gain during pregnancy: Results from the Norwegian mother and child cohort study (MoBa)

2008 • 40 citations

Genomic imprinting effects in a compromised in utero environment: Implications for a healthy pregnancy

2009 • 39 citations

Genes, the environment and the control of food intake

2004 • 39 citations

A Whole Genome Linkage Scan Identifies Multiple Chromosomal Regions Influencing Adiposity‐Related Traits among Samoans

2008 • 36 citations

Puberty, sexual milestones and abuse: how are they related in eating disorder patients?

1995 • 35 citations

Early handling reduces vulnerability of rats to activity‐based anorexia

2006 • 34 citations

The variability of phenomenology in anorexia nervosa

2000 • 33 citations

Epigenetic Marking and Neuronal Plasticity

2007 • 33 citations

Risk factors, correlates, and markers in early‐onset bulimia nervosa and EDNOS

2010 • 31 citations

Testing the validity of eating disorder diagnoses

2007 • 29 citations

Gut and Hormones and Obesity

2008 • 28 citations

Breast or bottle? Eating disordered childbearing women and infant‐feeding decisions

2008 • 28 citations

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

2009 • 27 citations

Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats

1994 • 27 citations

Cardiovascular Disease in Survivors of the Dutch Famine

2004 • 26 citations

Psychosocial Factors Associated With Broadly Defined Bulimia Nervosa During Early Pregnancy: Findings from the Norwegian Mother and Child Cohort Study

2008 • 21 citations

Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

2009 • 16 citations

Epigenetic Manifestations in Diet-Related Disorders

2008 • 15 citations

[Genetic determinants of obesity. Current issues].

2010 • 6 citations