Genetic Susceptibility to Eating Disorders: Associated Polymorphisms and Pharmacogenetic Suggestions

Central nervous system control of food intake

2000 • 6,305 citations

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

A Psychobiological Model of Temperament and Character

1993 • 5,380 citations

Allelic Variation of Human Serotonin Transporter Gene Expression

1996 • 2,225 citations

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

1996 • 1,780 citations

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

2003 • 1,665 citations

The spectrum of behaviors influenced by serotonin

1998 • 1,126 citations

A functional polymorphism in the monoamine oxidase A gene promoter

1998 • 1,070 citations

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

2003 • 887 citations

Strategy for Investigating Interactions Between Measured Genes and Measured Environments

2005 • 786 citations

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

1992 • 718 citations

The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants

2000 • 622 citations

A Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa

1998 • 605 citations

Prevalence, Heritability, and Prospective Risk Factors for Anorexia Nervosa

2006 • 571 citations

Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa: Evidence of Shared Liability and Transmission of Partial Syndromes

2000 • 545 citations

Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets

1999 • 523 citations

A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia

1997 • 454 citations

Serotonergic control of the organization of feeding and satiety

1995 • 419 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Fluoxetine After Weight Restoration in Anorexia Nervosa

2006 • 381 citations

Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations

2003 • 371 citations

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

1997 • 356 citations

Twin studies of eating disorders: A review

2000 • 335 citations

The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density

2005 • 310 citations

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

2000 • 304 citations

Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use

2004 • 269 citations

Blood Levels of the Endocannabinoid Anandamide are Increased in Anorexia Nervosa and in Binge-Eating Disorder, but not in Bulimia Nervosa

2005 • 258 citations

The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity

2004 • 254 citations

Heritability of binge-eating and broadly defined bulimia nervosa

1998 • 252 citations

Serotonin manipulations and the structure of feeding behaviour

1986 • 249 citations

Melanocortin 4 Receptor Mutations in a Large Cohort of Severely Obese Adults: Prevalence, Functional Classification, Genotype-Phenotype Relationship, and Lack of Association with Binge Eating

2006 • 235 citations

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations

2004 • 228 citations

Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1

2002 • 224 citations

Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?

1998 • 208 citations

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type

2003 • 202 citations

Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa

1998 • 184 citations

Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait

2000 • 171 citations

Association between an agouti-related protein gene polymorphism and anorexia nervosa

2001 • 168 citations

Linkage analysis of anorexia nervosa incorporating behavioral covariates

2002 • 166 citations

Phenotypes in Three Pedigrees with Autosomal Dominant Obesity Caused by Haploinsufficiency Mutations in the Melanocortin-4 Receptor Gene

1999 • 150 citations

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

2003 • 150 citations

The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects

2005 • 149 citations

Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention‐deficit/hyperactivity disorder

2004 • 146 citations

Cytokines and feeding

2001 • 146 citations

The Genetics of Anorexia Nervosa

2007 • 145 citations

Shared transmission of eating disorders and anxiety disorders

2005 • 145 citations

Systematic Mutation Screening of the Estrogen Receptor Beta Gene in Probands of Different Weight Extremes: Identification of Several Genetic Variants

1998 • 144 citations

Significant Linkage on Chromosome 10p in Families with Bulimia Nervosa

2003 • 142 citations

Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations

2004 • 141 citations

Pharmacologic Treatment of Eating Disorders

2002 • 138 citations

Association of Multiple DRD2 Polymorphisms with Anorexia Nervosa

2005 • 133 citations

The human genetics of anorexia nervosa

2003 • 131 citations

RAPID COMMUNICATION: A Novel Melanocortin 4 Receptor (MC4R) Gene Mutation Associated with Morbid Obesity

2001 • 129 citations

Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins

2003 • 127 citations

Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers

1997 • 126 citations

Functional Analysis of the Human D2 Dopamine Receptor Missense Variants

1996 • 125 citations

Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset

2007 • 122 citations

Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa

1997 • 117 citations

Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity

2004 • 108 citations

Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables

2004 • 107 citations

Association of anorexia nervosa with the high activity allele of the COMT gene: a family-based study in Israeli patients

2001 • 107 citations

Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and bingeing/purging subtypes

2003 • 103 citations

5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa

1999 • 102 citations

Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity

2004 • 99 citations

Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations

2004 • 99 citations

Eating disorders with binge-eating behaviour are associated with the s allele of the 3'-UTR VNTR polymorphism of the dopamine transporter gene.

2004 • 98 citations

Functional Analyses of Melanocortin-4 Receptor Mutations Identified from Patients with Binge Eating Disorder and Nonobese or Obese Subjects

2005 • 98 citations

The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [³H-] paroxetine binding in bulimic syndromes

2004 • 98 citations

Interacting Genetic Loci on Chromosomes 20 and 10 Influence Extreme Human Obesity

2003 • 96 citations

The 5-HT2A −1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres

2002 • 94 citations

Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients

2001 • 90 citations

No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive–compulsive disorder, anorexia nervosa, and alcoholism

1999 • 89 citations

Further Evidence of Association of OPRD1 & HTR1D Polymorphisms with Susceptibility to Anorexia Nervosa

2006 • 87 citations

Studies of serotonin function in anorexia nervosa

1996 • 87 citations

Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia nervosa

2002 • 87 citations

5-HT2A receptor gene polymorphism and eating disorders

2002 • 84 citations

The β3-Adrenergic Receptor Gene Trp64Arg Mutation is Overrepresented in Obese Women: Effects on Weight, BMI, Abdominal Fat, Blood Pressure, and Reproductive History in an Elderly Australian Population

1996 • 82 citations

Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice

2001 • 81 citations

A DRD4/BDNF gene–gene interaction associated with maximum BMI in women with bulimia nervosa

2007 • 79 citations

hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21

1999 • 78 citations

β3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa

1997 • 77 citations

Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region

2002 • 77 citations

Association of estrogen receptor β gene polymorphisms with bulimic disease in women

2003 • 76 citations

D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

2007 • 75 citations

Influence of heredity on dietary restraint, disinhibition, and perceived hunger in humans

2005 • 73 citations

Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index

2008 • 73 citations

Association between the brain‐derived neurotrophic factor 196G/A polymorphism and eating disorders

2003 • 73 citations

Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4)

2007 • 72 citations

Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa

2000 • 70 citations

Eating Disorders, Serotonin Transporter Polymorphisms and Potential Treatment Response

2004 • 69 citations

Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates

2005 • 68 citations

The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder

2006 • 67 citations

Dopamine Transporter Gene (DAT1) Associated with Appetite Suppression to Methylphenidate in a Case–Control Study of Binge Eating Disorder

2007 • 67 citations

Independent Confirmation of a Major Locus for Obesity on Chromosome 10

2000 • 67 citations

The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women

2008 • 66 citations

The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder

2006 • 65 citations

Altered norepinephrine metabolism following long-term weight recovery in patients with anorexia nervosa

1985 • 65 citations

Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa

2006 • 65 citations

No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region

1998 • 64 citations

Genetic factors in anorexia nervosa

1999 • 63 citations

Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls

2002 • 62 citations

No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity

1999 • 60 citations

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

2005 • 60 citations

Neuroendocrine dysregulation of food intake in eating disorders

2008 • 60 citations

Association of a functional serotonin transporter gene polymorphism with binge eating disorder

2005 • 60 citations

Serotonergic dysfunction across the eating disorders: relationship to eating behaviour, purging behaviour, nutritional status and general psychopathology

2000 • 59 citations

Investigation of the Serotonin Transporter Regulatory Region Polymorphism in Bulimia Nervosa: Relationships to Harm Avoidance, Nutritional Parameters, and Psychiatric Comorbidity

2006 • 57 citations

Epistatic interaction between the monoamine oxidase A and serotonin transporter genes in anorexia nervosa

2004 • 56 citations

No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa

2006 • 56 citations

From molecular biology to pharmacogenetics: a review of the literature on antidepressant treatment and suggestions of possible candidate genes

2004 • 56 citations

Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes

1998 • 56 citations

Types of Depression More Frequent in Bipolar than in Unipolar Affective Illness: Results of the Polish DEP-BI Study

2007 • 54 citations

Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population

2005 • 54 citations

The 5-HT2A –1438 A/G and 5-HTTLPR Polymorphisms and Personality Dimensions in Adolescent Anorexia Nervosa: Association Study

2006 • 52 citations

Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study

2002 • 52 citations

Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa

2001 • 52 citations

Intentional Weight Loss in Young Adults: Sex‐Specific Genetic and Environmental Effects

2005 • 52 citations

Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa

2004 • 52 citations

Lack of Association between Anorexia Nervosa and D3 Dopamine Receptor Gene

1998 • 51 citations

Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa

1999 • 49 citations

Combined family trio and case‐control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa

2003 • 49 citations

Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa

2003 • 49 citations

Association of catecholamine-O-methyltransferase and 5-HTTLPR genotype with eating disorder-related behavior and attitudes in females with eating disorders

2006 • 49 citations

Contribution of the serotoninergic system to anxious and depressive traits that may be partially responsible for the phenotypical variability of bulimia nervosa

2006 • 46 citations

Case–control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa

2006 • 44 citations

5-HT_2A gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa

2002 • 44 citations

Association of the promoter polymorphism −1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa

2005 • 43 citations

Gene-gene interaction between the monoamine oxidase A gene and solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype)

2003 • 40 citations

Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder

1999 • 40 citations

No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery

2006 • 39 citations

Psychopathological traits and 5-HT2A receptor promoter polymorphism (−1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa

2004 • 39 citations

Investigation of Epistasis Between the Serotonin Transporter and Norepinephrine Transporter Genes in Anorexia Nervosa

2003 • 37 citations

Association of Eating Disorders with Catechol-<i>O</i>-Methyltransferase Gene Functional Polymorphism

2006 • 37 citations

Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosa.

2007 • 37 citations

Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients

2003 • 36 citations

No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa

1999 • 35 citations

5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients

2001 • 33 citations

Selection of eating‐disorder phenotypes for linkage analysis

2005 • 30 citations

Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa

2004 • 29 citations

The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study

2007 • 28 citations

Haplotype analysis of the COMT‐ARVCF gene region in Israeli anorexia nervosa family trios

2005 • 23 citations

The serotonin-1Dβ receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa

2005 • 22 citations

CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: A case‐control study of female patients and several ethnic groups in the Israeli Jewish population

2004 • 22 citations

Analysis of tumor necrosis factor-α gene promoter polymorphisms in anorexia nervosa

2001 • 20 citations

Serotonin-2A receptor gene polymorphisms are associated with serotonin-induced platelet aggregation

2003 • 20 citations

Plasma norepinephrine after a standardized test meal in acute and remitted patients with anorexia nervosa and in healthy controls

1992 • 19 citations

Analysis of the −1438 G/A polymorphism of the 5-HT2A serotonin receptor gene in bulimia nervosa patients with or without a history of anorexia nervosa

2004 • 18 citations

Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa

2007 • 15 citations

A polymorphism in the 3′ untranslated region of the CCK gene is associated with anorexia nervosa in Dutch patients

2006 • 11 citations

Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa

2004 • 11 citations

[Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa].

2006 • 9 citations

Melanocortin-4 receptor molecular scanning and pro-opiomelanocortin R236G variant screening in binge eating disorder

2005 • 8 citations

TNF-α and intPLA2 genes' polymorphism in anorexia nervosa

2004 • 3 citations

5-HT2A gene promoter polymorphism and anorexia nervosa

1999 • 3 citations

Deleted Work

1955 • 0 citations