A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

Statistical Power Analysis for the Behavioral Sciences

1989 • 83,906 citations

Statistical power analysis for the behavioral sciences

1990 • 65,781 citations

The Yale-Brown Obsessive Compulsive Scale

1989 • 7,156 citations

Meta-Analytic Procedures for Social Research.

1994 • 4,403 citations

Meta-Analytic Procedures for Social Research

1991 • 4,330 citations

Meta-analysis in social research

1982 • 3,988 citations

Development and validation of measures of social phobia scrutiny fear and social interaction anxiety11Editor’s note: This article was written before the development of some contemporary measures of social phobia, such as the Social Phobia and Anxiety Inventory (Turner et al., 1989). We have invited this article for publication because of the growing interest in the scales described therein. S.T.

1998 • 3,040 citations

The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency

1994 • 2,415 citations

The practice of behavior therapy

1969 • 2,341 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Fear conditioning induces associative long-term potentiation in the amygdala

1997 • 1,285 citations

Energy on Demand

1999 • 1,162 citations

Cognitive Enhancers as Adjuncts to Psychotherapy

2004 • 1,058 citations

Randomized, Placebo-Controlled Trial of Exposure and Ritual Prevention, Clomipramine, and Their Combination in the Treatment of Obsessive-Compulsive Disorder

2004 • 966 citations

Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder

2000 • 949 citations

The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia

2001 • 915 citations

Randomized trial of prolonged exposure for posttraumatic stress disorder with and without cognitive restructuring: Outcome at academic and community clinics.

2005 • 891 citations

Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

1995 • 891 citations

Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala

1999 • 885 citations

Multicenter Collaborative Panic Disorder Severity Scale

1997 • 884 citations

Psychometric properties of the Liebowitz Social Anxiety Scale

1999 • 859 citations

Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats

2002 • 807 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

A Comparison of Cognitive Therapy, Applied Relaxation and Imipramine in the Treatment of Panic Disorder

1994 • 657 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

Neural systems involved in fear and anxiety measured with fear-potentiated startle.

2006 • 583 citations

Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder

2006 • 559 citations

Glycine transporters are differentially expressed among CNS cells

1995 • 515 citations

Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work

2006 • 497 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Alprazolam and Exposure Alone and Combined in Panic Disorder with Agoraphobia

1993 • 470 citations

Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation

2006 • 463 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

2003 • 435 citations

A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia

1999 • 435 citations

Modulation of N -methyl- <scp>d</scp> -aspartate receptor function by glycine transport

1998 • 410 citations

Glycine binding primes NMDA receptor internalization

2003 • 408 citations

Fluoxetine, Comprehensive Cognitive Behavioral Therapy, and Placeboin Generalized Social Phobia

2004 • 396 citations

The practice of behavior therapy

1970 • 395 citations

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1997 • 393 citations

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)

1997 • 388 citations

D-Cycloserine Augmented Exposure Therapy for Obsessive-Compulsive Disorder

2007 • 385 citations

Effects of D-cycloserine on extinction of conditioned freezing.

2003 • 384 citations

The practice of behavior therapy, 2nd ed.

1973 • 371 citations

Psychological treatment of panic: Work in progress on outcome, active ingredients, and follow-up

1993 • 369 citations

Consolidation of Extinction Learning Involves Transfer from NMDA-Independent to NMDA-Dependent Memory

2001 • 363 citations

Augmentation of Behavior Therapy With <scp>d</scp> -Cycloserine for Obsessive-Compulsive Disorder

2008 • 358 citations

A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder

2008 • 329 citations

d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics

1989 • 302 citations

Sarcosine or D-Serine Add-on Treatment for Acute Exacerbation of Schizophrenia

2005 • 267 citations

Long-term outcome in cognitive-behavioral treatment of panic disorder: Clinical predictors and alternative strategies for assessment.

1995 • 248 citations

d-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction

2005 • 242 citations

Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo

2003 • 230 citations

Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis

2004 • 206 citations

Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses

2002 • 205 citations

D-cycloserine does not enhance exposure–response prevention therapy in obsessive–compulsive disorder

2007 • 200 citations

Adjunctive high-dose glycine in the treatment of schizophrenia

2001 • 198 citations

Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene

1993 • 194 citations

D-Cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement.

2004 • 190 citations

Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype

2004 • 188 citations

Facilitation of Fear Extinction by D-Cycloserine: Theoretical and Clinical Implications

2004 • 185 citations

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

1996 • 170 citations

d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes

1990 • 168 citations

The Glycine Transporter Type 1 InhibitorN-[3-(4′-Fluorophenyl)-3-(4′-Phenylphenoxy)Propyl]Sarcosine Potentiates NMDA Receptor-Mediated ResponsesIn Vivoand Produces an Antipsychotic Profile in Rodent Behavior

2003 • 167 citations

Neurobiology of anxiety disorders and implications for treatment.

2006 • 164 citations

A randomized controlled trial of the effect of d-cycloserine on exposure therapy for spider fear

2006 • 160 citations

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

1996 • 157 citations

Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy*

2002 • 153 citations

Role of the Amygdala in Fear Extinction Measured with Potentiated Startle

2003 • 151 citations

d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference

2006 • 150 citations

Effects of multiple exposures to d-cycloserine on extinction of conditioned fear in rats

2005 • 146 citations

Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents

1995 • 144 citations

The G72/G30 Gene Complex and Cognitive Abnormalities in Schizophrenia

2006 • 139 citations

Postsynaptically Silent Synapses in Single Neuron Cultures

1998 • 138 citations

Enhancing exposure-based therapy from a translational research perspective

2007 • 135 citations

D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response.

2006 • 134 citations

Improved Cognition in Alzheimer’s Disease With Short-Term D-Cycloserine Treatment

1999 • 130 citations

Comparative effects of glycine and d-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis

2003 • 121 citations

Augmentation Treatment of Psychotherapy for Anxiety Disorders with D‐Cycloserine

2006 • 120 citations

Extinction Training in Conjunction with a Partial Agonist of the Glycine Site on the NMDA Receptor Erases Memory Trace

2006 • 113 citations

Long‐term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning

2002 • 110 citations

A six-month, placebo-controlled trial of d-cycloserine co-administered with conventional antipsychotics in schizophrenia patients

2004 • 109 citations

IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans

2000 • 107 citations

Developmental Expression of the Glycine Transporters GLYT1 and GLYT2 in Mouse Brain

1996 • 106 citations

Actions of ?-cycloserine at the ? glycine receptor site in vivo

1991 • 105 citations

A randomized controlled trial of the effect of d-cycloserine on extinction and fear conditioning in humans

2006 • 105 citations

White matter lesions in Fabry disease occur in ‘prior’ selectively hypometabolic and hyperperfused brain regions

2003 • 101 citations

Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala

2005 • 90 citations

Effects of d-cycloserine on negative symptoms in schizophrenia

2004 • 90 citations

Long-term memory of cocaine-associated context: disruption and reinstatement

2007 • 88 citations

Effects of d-cycloserine on extinction of learned fear to an olfactory cue

2007 • 84 citations

Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists

1999 • 83 citations

Glutamate NMDA Receptors within the Amygdala Participate in the Modulatory Effect of Glucocorticoids on Extinction of Conditioned Fear in Rats

2006 • 74 citations

The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesic responses in the rat.

1994 • 74 citations

Influence of ethanol withdrawal on fear memory: Effect of d-cycloserine

2006 • 73 citations

Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures

1993 • 69 citations

D-cycloserine for Alzheimer's disease

2002 • 67 citations

Glycine Site Agonists of the NMDA Receptor: A Review

1995 • 57 citations

D-Cycloserine Treatment of Alzheimer Disease

1994 • 53 citations

Clinical Perspectives on the Combination of D-Cycloserine and Cognitive-Behavioral Therapy for the Treatment of Anxiety Disorders

2007 • 52 citations

Evaluation of Cycloserine in the Treatment of Alzheimer's Disease

1995 • 49 citations

Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices

2004 • 47 citations

Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo

1997 • 43 citations

Effects of D-Cycloserine on Extinction: Consequences of Prior Exposure to Imipramine

2007 • 43 citations

NMDA Partial Agonist Reverses Blocking of Extinction of Aversive Memory by GABAA Agonist in the Amygdala

2006 • 43 citations

Delay aversion: Effects of 7-OH-DPAT, 5-HT1A/1B-receptor stimulation and d-cycloserine

2006 • 42 citations

Facilitation of Extinction of Conditioned Fear by D-Cycloserine

2005 • 40 citations

d-Cycloserine and performance under different states of anxiety in healthy volunteers

2007 • 35 citations

The Glial and the Neuronal Glycine Transporters Differ in Their Reactivity to Sulfhydryl Reagents

2001 • 32 citations

D-Cycloserine enhances memory consolidation of hippocampus-dependent latent extinction

2007 • 32 citations

Emotional Learning and Glutamate: Translational Perspectives

2005 • 27 citations

Pharmacotherapy for performance anxiety disorders: Occasionally useful but typically contraindicated

2004 • 27 citations

Manipulation of NMDA-receptor activity alters extinction of an instrumental response in rats

1998 • 24 citations

Effects of light deprivation on recovery from neglect and extinction induced by unilateral lesions of the medial agranular cortex and dorsocentral striatum

2003 • 22 citations

Unilateral destruction of the dorsocentral striatum in rats produces neglect but not extinction to bilateral simultaneous stimulation

2002 • 21 citations

Glycine ketamine interactions in healthy humans

1997 • 18 citations

D-cycloserine Inhibits Amygdala Responses During Repeated Presentations of Faces

2007 • 15 citations

Quantitative gene expression of two types of glycine transporter in the rat central nervous system

1996 • 14 citations

Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety

2007 • 14 citations