The cytokine receptor superfamily

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic Syndromes

1987 • 653 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

1987 • 636 citations

Human T-lymphotropic retroviruses

1985 • 623 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

A new cytokine receptor superfamily

1990 • 506 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes

1986 • 460 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

1990 • 362 citations

Colony-stimulating factor-1 receptor

1990 • 362 citations

Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor

1981 • 340 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial

1989 • 293 citations

Autocrine secretion of GM-CSF in acute myeloblastic leukemia

1986 • 280 citations

The effects of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblastic leukemia

1987 • 273 citations

THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS

1966 • 258 citations

Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system

1988 • 258 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

Human erythropoietin receptor: cloning, expression, and biologic characterization

1990 • 242 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Molecular cloning and expression of the murine interleukin-5 receptor.

1990 • 227 citations

Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells.

1987 • 227 citations

Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia

1986 • 223 citations

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

1990 • 213 citations

Erythropoietin receptor and interleukin-2 receptor β chain: A new receptor family

1989 • 208 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.

1988 • 202 citations

Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domains.

1987 • 193 citations

Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.

1984 • 192 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

Transformation by v- sis Occurs by an Internal Autoactivation Mechanism

1989 • 171 citations

Heterogeneity in Human Interleukin-3 Receptors

1989 • 153 citations

Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.

1990 • 150 citations

Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor.

1986 • 149 citations

Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.

1990 • 149 citations

Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10) [see comments]

1990 • 148 citations

Identification and analysis of human erythropoietin receptors on a factor-dependent cell line, TF-1

1989 • 146 citations

Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia

1986 • 139 citations

The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p

1990 • 128 citations

HIV-1, HTLV-1 and normal T-cell growth: transcriptional strategies and surprises

1989 • 126 citations

Kinases and phosphatases in T-cell activation

1989 • 118 citations

COOH-Terminal-Modified Interleukin-3 Is Retained Intracellularly and Stimulates Autocrine Growth

1989 • 117 citations

Localization of the human GM-CSF receptor gene to the X–Y pseudoautosomal region

1990 • 113 citations

Receptors for erythropoietin in mouse and human erythroid cells and placenta

1989 • 111 citations

Growth Hormone Mediates the Growth of TLymphoblast Cell Lines via Locally Generated Insulin-Like Growth Factor-I*

1990 • 104 citations

Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells.

1990 • 99 citations

Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines.

1989 • 99 citations

Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.

1988 • 79 citations

Erythropoietin receptors on murine erythroid colony-forming units: natural history

1989 • 78 citations

Protein tyrosine phosphorylation associated with activation of the interleukin 2 receptor.

1990 • 75 citations

Autocrine growth factors and tumourigenic transformation

1990 • 75 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation.

1988 • 68 citations

Autocrine growth mechanisms of the progenitors of blast cells in acute myeloblastic leukemia

1989 • 68 citations

The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.

1989 • 52 citations

Characterization of granulocyte-macrophage colony-stimulating factor receptor on the blast cells of acute myeloblastic leukemia

1990 • 51 citations

The IL-2 receptor beta-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms.

1990 • 50 citations

Stimulation of the antigen and interleukin-2 receptors on T lymphocytes activates distinct tyrosine protein kinases.

1990 • 42 citations

Interleukin 6 and plasma cell neoplasias

1989 • 38 citations

The 75,000-Dalton Interleukin-2 Receptor Transmits a Signal for the Activation of a Tyrosine Protein Kinase

1989 • 32 citations

Serum levels of soluble interleukin‐2 receptor in hairy cell leukaemia: a reliable marker of neoplastic bulk

1989 • 31 citations

Expression and modulation of IL‐3 and GM‐CSF receptors in human growth factor dependent leukaemic cells

1990 • 29 citations

New cytokines and receptors make their debut in San Antonio

1991 • 24 citations

DIFFERENTIAL IL-2 RECEPTOR EXPRESSION IN RENAL ALLOGRAFT RECIPIENTS TREATED WITH AN ANTI-IL-2-RECEPTOR ANTIBODY

1989 • 20 citations

Evaluation of serum levels of soluble interleukin-2 receptor in patients with chronic lymphoproliferative disorders of T-lymphocytes

1989 • 17 citations