Effects of 2-mercaptoethanol and buthionine sulfoximine on cystine metabolism by and proliferation of mitogen-stimulated human and mouse lymphocytes

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Glutathione: interorgan translocation, turnover, and metabolism.

1979 • 601 citations

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

1980 • 409 citations

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

1990 • 383 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Transport of cystine and cysteine in mammalian cells

1984 • 329 citations

Interorgan amino acid nutrition

1982 • 193 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

Enhancement of antibody synthesis in vitro by mercaptoethanol

1972 • 160 citations

Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine

1987 • 156 citations

Induction of 32- and 34-kDa stress proteins by sodium arsenite, heavy metals, and thiol-reactive agents.

1986 • 138 citations

Glutathione Regulates Interleukin-2 Activity on Cytotoxic T-cells

1989 • 127 citations

The interorgan metabolism of glutathione

1980 • 116 citations

Sulfhydryl dependence in primary explant hematopoietic cells. Inhibition of growth in vitro with vitamin B12 compounds.

1975 • 98 citations

Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation

1987 • 91 citations

Abnormal Amino-Acid Concentrations in the Blood of Patients with Acquired Immunodeficiency Syndrome (AIDS) May Contribute to the Immunological Defect

1988 • 90 citations

Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide

1987 • 89 citations

Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes

1979 • 88 citations

Mechanism of augmentation of the antibody response in vitro by 2-mercaptoethanol in murine lymphocytes. I. 2-Mercaptoethanol-induced stimulation of the uptake of cystine, an essential amino acid.

1982 • 84 citations

Effect of diethylmaleate and other glutathione depletors on protein synthesis

1986 • 78 citations

Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen

1986 • 76 citations

Abnormalities of blood selenium and glutathione peroxidase activity in patients with acquired immunodeficiency syndrome and aids-related complex

1988 • 73 citations

Oxidative phenomena are implicated in human T-cell stimulation.

1988 • 64 citations

Cystine requirement of continuous human lymphoid cell lines of normal and leukemic origin.

1977 • 62 citations

Determination of glutathione in lymphocytes and possible association of redox state and proliferative capacity of lymphocytes

1981 • 61 citations

Mechanism of augmentation of the antibody response in vitro by 2-mercaptoethanol in murine lymphocytes

1983 • 60 citations

Formation of sulfhydryl groups in the culture medium by human diploid fibroblasts

1980 • 57 citations

Modulation of T-cell function

1981 • 56 citations

Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine

1989 • 49 citations

Immune oxidative injury induced in mice exposed to normobaric O2: effects of thiol compounds on the splenic cell sulfhydryl content and Con A proliferative response.

1985 • 44 citations

Fluorometric quantitation of cellular and nonprotein thiols

1986 • 43 citations

Characteristics of cystine and cysteine transport in rat kidney cortex slices.

1968 • 42 citations

Evidence that glutathione participates in the induction of a stress protein

1986 • 33 citations

Mechanism of augmentation of the antibody response in vitro by 2-mercaptoethanol in murine lymphocytes

1983 • 29 citations

Unique Characteristics of Rat Spleen Lymphocyte, L1210 Lymphoma and HeLa Cells in Glutathione Biosynthesis from Sulfur-Containing Amino Acids

1982 • 28 citations

Dithiothreitol in the study of cysteine transport

1966 • 27 citations

Enhanced transport of natural amino acids after activation of pig lymphocytes

1979 • 26 citations

Nonspecific activation of murine lymphocytes. II. Parameters of the interaction between splenic lymphocytes and radiolabeled 2-mercaptoethanol in vitro.

1978 • 23 citations

Flow cytometric analysis of protein thiol groups in relation to the cell cycle and the intracellular content of glutathione in rat hepatocytes

1989 • 17 citations

[Blood deficiency values of polyunsaturated fatty acids of phospholipids, vitamin E and glutathione peroxidase as possible risk factors in the onset and development of acquired immunodeficiency syndrome].

1990 • 14 citations

Activation of murine lymphocytes by 2-mercaptoethanol and related thiol compounds and its mechanism. II Effect of thiol compounds on the viability of the lymphocytes under a cystine-deficient culture condition.

1986 • 2 citations