Novel mutational spectrum induced by N-methyl-N′-nitro-N-nitrosoguanidine in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Genetic studies of the lac repressor

1977 • 610 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Mutational specificity of depurination.

1984 • 361 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography

1980 • 301 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

1983 • 222 citations

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

1990 • 210 citations

Mechanism of mutagenesis by O6-methylguanine

1984 • 191 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells

1991 • 169 citations

DNA strand specificity for UV-induced mutations in mammalian cells.

1989 • 169 citations

The role of DNA polymerase in base substitution mutagenesis on non-instructional templates

1982 • 160 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells

1989 • 138 citations

Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

1989 • 129 citations

Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene.

1990 • 128 citations

Correlation between O⁶-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N′-nitro-N-nitrosoguanidine

1984 • 119 citations

Influence of neighbouring base sequence on N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli

1987 • 107 citations

Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells.

1991 • 107 citations

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes.

1989 • 103 citations

Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O⁶-guanine position of dGTP

1983 • 86 citations

Kinds and location of mutations induced by (±)-7β,8α- dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts

1991 • 78 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.

1990 • 69 citations

O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.

1986 • 66 citations

Role of neighbouring bases and assessment of strand specificity in ethylmethanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis in the SUP4-o gene of Saccharomyces cerevisiae

1988 • 64 citations

Escherichia coli polymerase I can use O2-methyldeoxythymidine or O4-methyldeoxythymidine in place of deoxythymidine in primed poly(dA-dT).poly(dA-dT) synthesis.

1983 • 61 citations

DNA base changes in benzo [α]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hamster ovary cells

1990 • 53 citations

Analysis of forward mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the bacteriophage P22 mnt repressor gene

1986 • 47 citations

Human O⁶-alkylguanine-DNA alkyltransferase fails to repair O⁴-methylthymine and methyl phosphotriesters in DNA as efficiently as does the alkyltransferase from Escherichia coli

1985 • 44 citations

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

1984 • 44 citations

DNA base changes induced following in vivo exposure of unadapted, adapted or Ada− Escherichia coli to N-methyl-N′-nitro-N-nitrosoguanidine

1987 • 37 citations

Comparative efficiency of forming m4T.cntdot.G versus m4T.cntdot.A base pairs at a unique site by use of Escherichia coli DNA polymerase I (Klenow fragment) and Drosophila melanogaster polymerase .alpha.-primase complex

1990 • 35 citations

Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.

1988 • 31 citations

HPRT gene organization and expression.

1987 • 28 citations