Homologous desensitization of bombesin‐induced increases in intracellular Ca²⁺ in quiescent swiss 3T3 cells involves a protein kinase C‐independent mechanism

Inositol phosphates and cell signalling

1989 • 4,058 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.

1991 • 330 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Cloning and Functional Characterization of a Complementary DNA Encoding the Murine Fibroblast Bombesin/Gastrin-Releasing Peptide Receptor

1990 • 256 citations

Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

1991 • 230 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Neuropeptides as cellular growth factors: role of multiple signalling pathways

1991 • 131 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin.

1988 • 125 citations

Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells. Effect of guanine nucleotides.

1988 • 120 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester

1992 • 90 citations

Arachidonic acid release by bombesin. A novel postreceptor target for heterologous mitogenic desensitization.

1990 • 76 citations

Synergistic signals in mitogenesis: role of ion fluxes, cyclic nucleotides and protein kinase c in swiss 3t3 cells

1985 • 73 citations

Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization.

1990 • 69 citations

Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.

1988 • 67 citations

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

1988 • 57 citations

Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

1983 • 56 citations

Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanisms

1989 • 52 citations

The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMP.

1992 • 47 citations

Phorbol esters and diacylglycerol inhibit vasopressin-induced increases in cytoplasmic-free Ca2+ and 45Ca2+ efflux in Swiss 3T3 cells

1986 • 39 citations

Single-cell analysis of the mitogen-induced calcium responses of normal and protein kinase C-depleted Swiss 3T3 cells.

1989 • 31 citations

The rapid desensitization of receptors for platelet derived growth factor, bradykinin and ATP: Studies on individual cells using quantitative digital video fluorescence microscopy

1988 • 24 citations

Heterologous desensitization of bombesin-induced mitogenesis by prolonged exposure to vasopressin: a post-receptor signal transduction block.

1989 • 23 citations

Heterologous desensitization of platelet-derived growth factor-mediated arachidonic acid release and prostaglandin synthesis.

1992 • 14 citations