Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

1986 • 1,644 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Receptors for the TGF-β family

1992 • 638 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

Production of transforming growth factor beta 1 during repair of arterial injury.

1991 • 539 citations

α ₂ “Macroglobulin, a multifunctional binding protein with targeting characteristics

1992 • 454 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Clearance and binding of two electrophoretic “fast” forms of human alpha 2-macroglobulin.

1981 • 398 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α₂‐macroglobulin receptor

1990 • 320 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.

1992 • 295 citations

Expression of smooth muscle and nonmuscle myosin heavy chains in cultured vascular smooth muscle cells.

1986 • 233 citations

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

1983 • 220 citations

Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins.

1991 • 216 citations

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta.

1990 • 214 citations

Human transforming growth factor beta.alpha 2-macroglobulin complex is a latent form of transforming growth factor beta.

1988 • 209 citations

Physical properties of human α2-macroglobulin following reaction with methylamine and trypsin

1982 • 188 citations

Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.

1984 • 186 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

1990 • 148 citations

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.

1991 • 139 citations

Vascular Smooth Muscle Cells Express Distinct Transforming Growth Factor-β Receptor Phenotypes as a Function of Cell Density in Culture

1989 • 137 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth.

1993 • 130 citations

Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors.

1984 • 95 citations

Effects of transforming growth factor-β1 on growth of aortic smooth muscle cells Influences of interaction with growth factors, cell state, cell phenotype, and cell cycle

1991 • 64 citations

Transforming growth factor β1 is a powerful modulator of platelet‐derived growth factor action in vascular smooth muscle cells

1992 • 64 citations

PDGF‐stimulated fibroblast proliferation is enhanced synergistically by receptor‐recognized α₂‐Macroglobulin

1990 • 56 citations

Alpha 2-macroglobulin: a protein at the interface of fibrinolysis and cellular growth regulation.

1992 • 51 citations

Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin-proteinase complexes

1992 • 37 citations

Analysis of the mitogenic effect of fetuin preparations on arterial smooth muscle cells: The role of contaminant platelet‐derived growth factor

1985 • 30 citations

Inhibitory effect of transforming growth factor-β on epidermal growth factor-induced proliferation of cultured rat aortic smooth muscle cells

1988 • 24 citations

ANG II- or AVP-induced increases in protein synthesis are not dependent on autocrine secretion of PDGF-AA

1993 • 23 citations

Inhibition of adrenocortical steroidogenesis by α2-macroglobulin is caused by associated transforming growth factor β

1992 • 16 citations