Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

1988 • 595 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Induction of protooncogene c-jun by serum growth factors.

1988 • 438 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Identification and purification of a polypeptide that binds to the c-fos serum response element.

1987 • 398 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning.

1982 • 280 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

1988 • 249 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

1989 • 220 citations

Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.

1990 • 218 citations

New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin

1987 • 205 citations

The biology and medicine of signal transduction

1991 • 185 citations

Identification of c-fos sequences involved in induction by insulin and phorbol esters.

1988 • 184 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

Casein kinase II enhances the DNA binding activity of serum response factor.

1990 • 181 citations

Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.

1988 • 180 citations

Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.

1987 • 156 citations

Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.

1990 • 156 citations

Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cells

1982 • 150 citations

Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester

1990 • 143 citations

Two distinct cellular phosphoproteins bind to the c-fos serum response element.

1989 • 140 citations

Structure-activity relationship within a series of okadaic acid derivatives

1990 • 139 citations

Okadaic acid as the causative toxin of diarrhetic shellfish poisoning in Europe.

1986 • 136 citations

The simultaneous extraction of high-molecular-weight DNA and of RNA from solid tumors

1983 • 136 citations

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.

1989 • 135 citations

Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse Skin

1988 • 129 citations

c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

1987 • 126 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Purification of intercalator-released p67, a polypeptide that interacts specifically with the c-fos serum response element

1987 • 92 citations

Skin Carcinogenesis. Mechanisms and Human Relevance.

1989 • 90 citations

Apparent “activation” of protein kinases by okadaic acid class tumor promoters

1989 • 87 citations

Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A.

1990 • 67 citations

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.

1990 • 66 citations

Specific binding ofadaic acid, a new tumor promoter in mouse skin

1989 • 63 citations

Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

1988 • 60 citations

Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways.

1989 • 59 citations

Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo

1988 • 43 citations

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

1989 • 42 citations

Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis

1988 • 41 citations

Elevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin

1990 • 38 citations

Effect of okadaic acid on phosphorylation-dephosphorylation of myosin light chain in aortic smooth muscle homogenate

1988 • 36 citations

Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid.

1987 • 33 citations

Induction of Interleukin-2 Receptor-α Gene Expression Is Regulated by Post-translational Activation of κ B Specific DNA Binding Proteins

1989 • 32 citations

Molecular cloning of sequences activated during multi-stage carcinogenesis in mouse skin

1986 • 31 citations

The binding of 7,12-dimethylbenz(a)anthracene to replicating and non-replicating DNA in mouse skin

1974 • 30 citations

Isolation and characterization of complementary DNA clones corresponding to genes induced in mouse epidermis in vivo by tumor promoters.

1990 • 27 citations

Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7- -(4-azidobenzoyl)okadaate

1990 • 19 citations

Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin

1991 • 9 citations