IL-12 Signaling Drives CD8+ T Cell IFN-γ Production and Differentiation of KLRG1+ Effector Subpopulations during Toxoplasma gondii Infection

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

2007 • 824 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Regulation and Function of T-Cell-Mediated Immunity duringToxoplasma gondiiInfection

1998 • 685 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

1991 • 617 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.

1992 • 563 citations

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

2004 • 547 citations

Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

2003 • 494 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.

1989 • 355 citations

CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool

2003 • 355 citations

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

2006 • 323 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen,Toxoplasma gondii

2000 • 296 citations

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

2007 • 273 citations

Immediate Cytotoxicity But Not Degranulation Distinguishes Effector and Memory Subsets of CD8+ T Cells

2004 • 265 citations

De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii

2002 • 254 citations

Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-γ– and Tumor Necrosis Factor (TNF)-α–dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii

1999 • 244 citations

Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.

1995 • 239 citations

Viral Infections Induce Abundant Numbers of Senescent CD8 T Cells

2001 • 236 citations

Generation of CD8 T Cell Memory Is Regulated by IL-12

2007 • 219 citations

Interleukin-12 enhances murine survival against acute toxoplasmosis

1994 • 203 citations

Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation

2006 • 199 citations

CD8+ T cells are the major lymphocyte subpopulatlon involved in the protective immune response toToxoplasma gondiiin mice

1991 • 183 citations

Cutting Edge: Dendritic Cells Are Essential for In Vivo IL-12 Production and Development of Resistance againstToxoplasma gondiiInfection in Mice

2006 • 177 citations

Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion

2006 • 167 citations

IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12

2004 • 167 citations

Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation

2005 • 162 citations

IL-12 Receptor β2 (IL-12Rβ2)-Deficient Mice Are Defective in IL-12-Mediated Signaling Despite the Presence of High Affinity IL-12 Binding Sites

2000 • 161 citations

Coordinate Analysis of Murine Immune Cell Surface Markers and Intracellular Phosphoproteins by Flow Cytometry

2005 • 134 citations

Strength of Stimulus and Clonal Competition Impact the Rate of Memory CD8 T Cell Differentiation

2007 • 132 citations

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

2003 • 127 citations

Tyk2 Negatively Regulates Adaptive Th1 Immunity by Mediating IL-10 Signaling and Promoting IFN-γ-Dependent IL-10 Reactivation

2006 • 99 citations

CD8⁺-T-Cell Immunity againstToxoplasma gondiiCan Be Induced but Not Maintained in Mice Lacking Conventional CD4⁺T Cells

2002 • 91 citations

Cutting Edge: T-bet and IL-27R Are Critical for In Vivo IFN-γ Production by CD8 T Cells during Infection

2008 • 89 citations

IL-12 and Type-I IFN Synergize for IFN-γ Production by CD4 T Cells, Whereas Neither Are Required for IFN-γ Production by CD8 T Cells afterListeria monocytogenesInfection

2007 • 85 citations

IL-15 Prolongs the Duration of CD8+ T Cell-Mediated Immunity in Mice Infected with a Vaccine Strain ofToxoplasma gondii

1999 • 78 citations

IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells

1998 • 74 citations

Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection.

1999 • 66 citations

Differential Regulation of Killer Cell Lectin-Like Receptor G1 Expression on T Cells

2003 • 66 citations

Properties of murine CD8+CD27- T cells

2005 • 61 citations

Augmentation of the CD8+ T Cell Response by IFN-γ in IL-12-Deficient Mice DuringToxoplasma gondiiInfection

1999 • 59 citations

CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-γ, and Protect the Host against Tuberculosis Infection

2007 • 46 citations

Involvement of CD27/CD70 interactions in antigen-specific cytotoxic T-lymphocyte (CTL) activity by perforin-mediated cytotoxicity

2002 • 31 citations

Absence of a role for natural killer cells in the control of acute infection by Toxoplasma gondii oocysts.

1988 • 18 citations