Quiescence-Inducing and Antiapoptotic Activities of IL-15 Enhance Secondary CD4+ T Cell Responsiveness to Antigen

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

1986 • 380 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

Chemoattraction of human blood T lymphocytes by interleukin-15.

1995 • 303 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

From Naive to Memory T Cells

1996 • 252 citations

IL-6 rescues resting mouse T cells from apoptosis.

1997 • 246 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

Cellular environments and apoptosis: tissue microenvironments control activated T-cell death

1997 • 226 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

Interleukin 7 is a T-cell growth factor.

1989 • 206 citations

Fas and the art of lymphocyte maintenance.

1996 • 196 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.

1995 • 168 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses

1998 • 160 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells

2011 • 130 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor.

1995 • 107 citations

Regulation of T cell proliferation by IL-7.

1990 • 105 citations

Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis.

1996 • 80 citations

Interleukin‐15 up‐regulates interleukin‐2 receptor α chain but down‐regulates its own high‐affinity binding sites on human T and B cells

1996 • 67 citations

APOPTOSIS AND THE IMMUNE RESPONSE

1996 • 66 citations

Fibroblasts prevent apoptosis of IL‐2‐deprived T cells without inducing proliferation: a selective effect on Bcl‐x_L expression

1996 • 64 citations

DIFFERENTIAL REGULATION OF HUMAN T LYMPHOBLAST FUNCTIONS BY IL-2 AND IL-15

1997 • 58 citations

Induction of sensitivity to activation‐induced death in primary CD4⁺ cells: A role for interleukin‐2 in the negative regulation of responses by mature CD4⁺ T cells

1996 • 53 citations

T cell activation through TCR/-CD3 complex. IL-2 production of T cell clones stimulated with anti-CD3 without cross-linkage.

1992 • 22 citations