The apolipoprotein multigene family: biosynthesis, structure, structure-function relationships, and evolution.
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Abstract
References (226)
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A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
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Human apolipoprotein E. The complete amino acid sequence.
1982 • 731 citations
A molecular theory of lipid—protein interactions in the plasma lipoproteins
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Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.
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A specific apoprotein activator for lipoprotein lipase
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Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins].
1980 • 639 citations
Animal lipoproteins: chemistry, structure, and comparative aspects
1980 • 625 citations
Complete protein sequence and identification of structural domains of human apolipoprotein B
1986 • 620 citations
Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II
1978 • 609 citations
Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.
1980 • 586 citations
Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane
1986 • 509 citations
Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein
1972 • 497 citations
Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat.
1979 • 443 citations
Molecular Evolutionary Genetics
1985 • 432 citations
Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins
1978 • 430 citations
Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.
1980 • 428 citations
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100
1986 • 423 citations
Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.
1985 • 422 citations
The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis
1979 • 408 citations
Polymorphism of apolipoprotein E
1979 • 405 citations
Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin. Cholesterol acyltransferase
1975 • 392 citations
Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
1981 • 391 citations
Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
1980 • 365 citations
Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.
1985 • 361 citations
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.
1985 • 352 citations
Apolipoprotein B: Structural and Metabolic Heterogeneity
1983 • 351 citations
Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.
1982 • 349 citations
STUDIES ON THE SYNTHESIS AND SECRETION OF SERUM LIPOPROTEINS BY RAT LIVER SLICES
1960 • 342 citations
Activation of lecithin: cholesterol acyltransferase by human apolipoprotein A-IV.
1985 • 339 citations
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
1985 • 301 citations
Secondary structures of proteins and peptides in amphiphilic environments. (A review).
1983 • 299 citations
Apoproteins B and A-I and coronary artery disease in humans.
1984 • 289 citations
Nucleotide sequence and structure of the human apolipoprotein E gene.
1985 • 289 citations
Human Apolipoprotein B: Structure of Carboxyl-Terminal Domains, Sites of Gene Expression, and Chromosomal Localization
1985 • 280 citations
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
1983 • 276 citations
Isolation and characterization of the human apolipoprotein A-I gene.
1983 • 243 citations
Structure of the human apolipoprotein B gene.
1986 • 237 citations
The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms.
1986 • 230 citations
The complete cDNA and amino acid sequence of human apolipoprotein B-100.
1986 • 227 citations
The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.
1983 • 226 citations
Cloning and expression of human apolipoprotein D cDNA.
1986 • 217 citations
Structure and evolution of the apolipoprotein multigene family
1986 • 214 citations
A cholesteryl ester transfer complex in human plasma.
1980 • 214 citations
Polymorphism of Apolipoprotein E
1980 • 212 citations
The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide.
1980 • 204 citations
Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.
1986 • 179 citations
Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.
1984 • 178 citations
The Influence of Lipid on the Conformation of Human Plasma High Density Apolipoproteins
1972 • 172 citations
Proteolytic processing of human preproapolipoprotein A-I. A proposed defect in the conversion of pro A-I to A-I in Tangier's disease.
1983 • 167 citations
Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.
1976 • 166 citations
The primary translation product of rat intestinal apolipoprotein A-I mRNA is an unusual preproprotein.
1982 • 166 citations
Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II.
1977 • 164 citations
The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man
1982 • 161 citations
Lipoprotein Mutations in Pigs Are Associated with Elevated Plasma Cholesterol and Atherosclerosis
1986 • 156 citations
The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.
1986 • 156 citations
Mapping of antigenic determinants of human apolipoprotein B using monoclonal antibodies against low density lipoproteins.
1982 • 152 citations
PHYLOGENIES CONSTRAINED BY THE CROSSOVER PROCESS AS ILLUSTRATED BY HUMAN HEMOGLOBINS AND A THIRTEEN-CYCLE, ELEVEN-AMINO-ACID REPEAT IN HUMAN APOLIPOPROTEIN A-I
1977 • 152 citations
The Synthesis of Plasma Lipoprotein by Rat Liver
1959 • 152 citations
Ovomucoid intervening sequences specify functional domains and generate protein polymorphism
1980 • 152 citations
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
1984 • 151 citations
Intron–exon splice junctions map at protein surfaces
1982 • 148 citations
Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.
1983 • 145 citations
Intron/exon structure of the chicken pyruvate kinase gene
1985 • 144 citations
Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.
1984 • 138 citations
Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA.
1983 • 137 citations
Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins.
1983 • 137 citations
DNA Sequence of the Human Apolipoprotein B Gene
1987 • 136 citations
Gene structure of human apolipoprotein Al
1983 • 133 citations
The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.
1982 • 133 citations
Human apoHpoprotetas AI, AII, CII and CIII. cDNA sequences and mRNA abundance
1984 • 132 citations
Stimulation of the Synthesis of Very Low Density Lipoproteins in Rooster Liver by Estradiol
1974 • 131 citations
Apolipoprotein B synthesis by human liver and intestine in vitro.
1986 • 129 citations
Repeated helical pattern in apolipoprotein-A-I
1977 • 120 citations
A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.
1984 • 112 citations
In vitro conversion of proapoprotein A-I to apoprotein A-I. Partial characterization of an extracellular enzyme activity.
1983 • 112 citations
Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.
1984 • 109 citations
Human Apolipoprotein D Gene: Gene Sequence, Chromosome Localization, and Homology to the α2u-Globulin Superfamily
1987 • 108 citations
Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino acid segment with amphipathic helical potential.
1984 • 107 citations
Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.
1986 • 106 citations
Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.
1984 • 103 citations
Antigen Polymorphism of a Low-Density Beta-Lipoprotein. Allotypy in Human Serum
1962 • 103 citations
Characterization and immunoassay of apolipoprotein D
1981 • 102 citations
On computer-assisted analysis of biological sequences: proline punctuation, consensus sequences, and apolipoprotein repeats.
1990 • 100 citations
Cellular Regulation of Secretion and Release
1982 • 98 citations
Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV
1986 • 97 citations
A Comparison of the Major Apolipoprotein from Pig and Human High Density Lipoproteins
1973 • 96 citations
Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2.
1985 • 96 citations
Comparative analysis of repeated sequences in rat apolipoproteins A-I, A-IV, and E.
1985 • 95 citations
Biosynthesis of human preproapolipoprotein A-II.
1983 • 94 citations
Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.
1985 • 92 citations
Localization of the structural gene for human apolipoprotein A-I on the long arm of human chromosome 11.
1984 • 91 citations
Extrahepatic synthesis of lipoproteins of plasma and chyle: role of the intestine.
1966 • 90 citations
Distribution and characterization of the serum lipoproteins and their apoproteins in the rainbow trout (Salmo gairdnerii)
1978 • 89 citations
Apolipoprotein/Lipid Interactions: Studies with Synthetic Polypeptide
1982 • 89 citations
Parallel expression of the MB19 genetic polymorphism in apoprotein B-100 and apoprotein B-48. Evidence that both apoproteins are products of the same gene.
1986 • 89 citations
Nucleotide sequence of cloned cDNA of human apolipoprotein A-l
1983 • 88 citations
Apolipoproteins and the association of egg yolk proteins with plasma high density lipoproteins after ovulation and follicular atresia in the rainbow trout (Salmo gairdneri).
1987 • 88 citations
Characterization of apolipoproteins in chicken serum and egg yolk
1972 • 87 citations
Structure, evolution, and regulation of chicken apolipoprotein A-I.
1987 • 85 citations
Isolation and Sequence Analysis of the Human Apolipoprotein CIII Gene and the Intergenic Region between the Apo AI and Apo CIII Genes
1984 • 84 citations
Human apolipoprotein A-I. Post-translational modification by fatty acid acylation.
1986 • 83 citations
Evolution of lipoproteins deduced from protein sequence data
1977 • 83 citations
The Interaction of Apolipoprotein-Serine with Phosphatidylcholine
1974 • 80 citations
PHOSPHOLIPID BINDING STUDIES WITH SYNTHETIC APOLIPOPROTEIN FRAGMENTS *
1980 • 80 citations
Molecular cloning of human LDL apolipoprotein B cDNA
1985 • 78 citations
Cloning and expression of apolipoprotein B, the major protein of low and very low density lipoproteins.
1985 • 77 citations
Physicochemical Properties of Bovine Serum High Density Lipoprotein
1972 • 76 citations
A synthetic amphiphilic helical docosapeptide with the surface properties of plasma apolipoprotein A-I
1979 • 76 citations
Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein.
1987 • 75 citations
CONCENTRATION AND COMPOSITION OF SERUM LIPOPROTEINS OF CHOLESTEROL-FED AND STILBESTROL-INJECTED BIRDS
1956 • 74 citations
The use of polymer-bound oximes for the synthesis of large peptides usable in segment condensation: synthesis of a 44 amino acid amphiphilic peptide model of apolipoprotein A-1
1985 • 74 citations
Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids.
1985 • 73 citations
Human apolipoprotein B cDNA clone isolation and demonstration that liver apolipoprotein B mRNA is 22 kilobases in length.
1985 • 73 citations
The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.
1985 • 72 citations
Apolipoprotein E gene mapping and expression: localization of the structural gene to human chromosome 19 and expression of ApoE mRNA in lipoprotein- and non-lipoprotein-producing tissues
1985 • 70 citations
Anti-apoprotein B monoclonal antibodies detect human low density lipoprotein polymorphism.
1984 • 70 citations
Evolution of the apolipoproteins. Structure of the rat apo-A-IV gene and its relationship to the human genes for apo-A-I, C-III, and E.
1986 • 69 citations
Origin of apolipoprotein A-I polymorphism in plasma.
1985 • 69 citations
PRODUCTION OF ATHEROMATOSIS IN THE AORTA OF THE BIRD BY THE ADMINISTRATION OF DIETHYLSTILBESTROL
1948 • 68 citations
Procollagen Genes: Further Sequence Studies and Interspecies Comparisons
1983 • 68 citations
Activation of lecithin:cholesterol acyltransferase by a synthetic model lipid-associating peptide.
1980 • 67 citations
Human apolipoprotein B: analysis of internal repeats and homology with other apolipoproteins.
1987 • 67 citations
A partial cDNA clone for human apolipoprotein B.
1985 • 64 citations
The synthesis of low- and high-density lipoproteins by rat liver in vitro
1958 • 64 citations
Biosynthesis of human preapolipoprotein A-IV.
1984 • 64 citations
Studies on Human Serum β1-Lipoprotein
1966 • 61 citations
Apoproteins of avian very low density lipoprotein: demonstration of a single high molecular weight apoprotein
1979 • 61 citations
Substitution in vitro of Lecithin–Cholesterol Acyltransferase
1980 • 60 citations
Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism.
1986 • 60 citations
[49] Genetic polymorphism in human apolipoprotein E
1986 • 59 citations
Characterisation of mRNAs encoding the precursor for human apolipoprotein CI
1984 • 58 citations
Cell-Free Translation of Human Liver Apolipoprotein AI and All mRNA Processing of Primary Translation Products
1983 • 58 citations
Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins.
1977 • 58 citations
Molecular cloning and expression of partial cDNAs and deduced amino acid sequence of a carboxyl-terminal fragment of human apolipoprotein B-100.
1985 • 58 citations
A synthetic amphiphilic .beta.-strand tridecapeptide: a model for apolipoprotein B
1984 • 57 citations
The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19.
1984 • 57 citations
Human apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11
1984 • 56 citations
The mechanism of lipid-binding by plasma lipoproteins
1975 • 56 citations
The chick as a laboratory model for the study of estrogen-induced hyperlipidemia
1973 • 55 citations
Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII
1984 • 55 citations
Chromosomal localization of the human apoprotein ci gene and of a polymorphic apoprotein AII gene
1984 • 55 citations
Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet.
1986 • 54 citations
Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.
1986 • 53 citations
Intrahepatic assembly of very low density lipoproteins. Phosphorylation of small molecular weight apolipoprotein B.
1984 • 52 citations
The gene for apolipoprotein C‐ll is closely linked to the gene for apolipoprotein E on chromosome 19
1984 • 51 citations
Molecular cloning of human apolipoprotein B cDNA
1985 • 51 citations
Biosynthesis of Low Density Lipoprotein by Cell-free Preparations of Rat Intestinal Mucosa
1970 • 50 citations
Human apolipoprotein A-II: Nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1
1984 • 50 citations
Evolution of the albumin: α-fetoprotein ancestral gene from the amplification of a 27 nucleotide sequence
1984 • 49 citations
Synthesis in vitro and Translocation of Apolipoprotein AI across Microsomal Vesicles
1981 • 49 citations
Human apolipoprotein B: identification of cDNA clones and characterization of mRNA
1985 • 48 citations
Comparison of the nucleotide sequence of cloned DNA coding for an apolipoprotein (apoVLDL-II) from avian blood and the amino acid sequence of an egg-yolk protein (apovitellenin I): equivalence of the two sequences
1981 • 45 citations
Observations on the conformation of human beta lipoprotein: evidence for the occurrence of beta structure.
1968 • 45 citations
The nucleotide sequence of the chicken apo very low density lipoprotein II gene
1983 • 45 citations
Human preproapolipoprotein C-II. Analysis of major plasma isoforms.
1986 • 43 citations
The human apolipoprotein B-100 gene: A highly polymorphic gene that maps to the short arm of chromosome 2
1985 • 43 citations
Linkage between familial hypercholesterolemia with xanthomatosis and the C3 polymorphism confirmed
1978 • 43 citations
Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes.
1985 • 42 citations
Lipoprotein Synthesis in the Cockerel Liver: Effects of Estrogen on Hepatic Polysomal Messenger Ribonucleic Acid Activities for the Major Apoproteins in Very Low and High Density Lipoproteins and for Albumin and Evidence for Precursors to These Secretory Proteins*
1980 • 42 citations
The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man
1984 • 41 citations
Cloning and structure analysis of the rat apolipoprotein A-1 cDNA
1984 • 40 citations
In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells.
1986 • 39 citations
Limited Tryptic Digestion of Human Serum Low‐Density Lipoprotein: Islation and Characterisation of the‐Deficient Particle and of Its Apoprotien
1978 • 39 citations
The human apolipoprotein A-II gene is located on chromosome 1
1984 • 39 citations
Isolation and characterization of a dog serum lipoprotein having apolipoprotein A-I as its predominant protein constituent
1976 • 39 citations
Molecular cloning of partial cDNAs for rabbit liver apolipoprotein B and the regulation of its mRNA levels by dietary cholesterol.
1986 • 37 citations
Amino acid sequence of the signal peptide of apoVLDL-II, a major apoprotein in avian very low density lipoproteins.
1980 • 36 citations
Experimental atherosclerosis as observed in the chicken
1961 • 36 citations
Human proapolipoprotein A-II is cleaved following secretion from Hep G2 cells by a thiol protease.
1984 • 35 citations
Structure and expression of dog apolipoprotein C-II and C-III mRNAs. Implications for the evolution and functional constraints of apolipoprotein structure.
1987 • 35 citations
Molecular cloning of the gene sequences of a major apoprotein in avian very low density lipoproteins
1980 • 34 citations
Hormonal Control of Apolipoprotein Synthesis
1983 • 33 citations
Chicken apolipoprotein A-I: cDNA sequence, tissue expression and evolution
1987 • 33 citations
Activation of phosphatidylcholine–sterol acyltransferase by human apolipoprotein E isoforms
1985 • 32 citations
Comparison of the human apolipoprotein genes
1985 • 32 citations
Biosynthesis of Lipoprotein by Rat Intestinal Mucosa
1966 • 32 citations
Temperature dependence of the optical activity of human serum low density lipoprotein. Role of lipids
1975 • 31 citations
Biosynthesis of high density lipoprotein by chicken liver: intracellular transport and proteolytic processing of nascent apolipoprotein A-1.
1985 • 30 citations
Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B.
1985 • 29 citations
cDNA sequences of two apolipoproteins from lamprey
1987 • 28 citations
Human apolipoprotein B: Chromosomal mapping and DNA polymorphisms of hepatic and intestinal species
1986 • 27 citations
Structure and conformational analysis of lipid-associating peptides of apolipoprotein B-100 produced by trypsinolysis
1989 • 26 citations
Cloning and regulation of rat apolipoprotein B mRNA
1987 • 26 citations
Cloning and structural characterization of an estrogen-dependent apolipoprotein gene.
1981 • 26 citations
The nudeotide sequence of the Very Low Density Lipoprotein II mRNA from chicken
1981 • 25 citations
Effects of actinomycin D on the biosynthesis of plasma lipoproteins
1968 • 24 citations
Serum Apolipoprotein AI Synthesis in Rat Hepatocytes and its Secretion as Proform
1983 • 24 citations
Structural organization of apolipoprotein B-100 of human plasma low density lipoproteins. Comparison to B-48 of chylomicrons and very low density lipoproteins.
1986 • 24 citations
Regulation of apo-A-I processing in cultured hepatocytes.
1986 • 22 citations
Biochemical and immunological evidence for the presence of an apolipoprotein b-like component in the serum low-density lipoproteins of several animal species
1977 • 18 citations
Synthesis, transport, and processing of apolipoproteins of high density lipoproteins
1984 • 18 citations
Proteolytic Processing and Compartmentalization of the Primary Translation Products of Mammalian Apolipoprotein Mrna
1986 • 17 citations
Gene for apolipoprotein CII is on human chromosome 19
1984 • 16 citations
Complete nucleotide sequence of the gene encoding the rat apolipoprotein E
1986 • 14 citations
Structure of the chicken apo very low density lipoprotein II gene.
1981 • 14 citations
The complete amino acid sequence of proapolipoprotein A‐I of chicken high density lipoproteins
1987 • 14 citations
Signal Peptides: Properties and Interactions
1982 • 10 citations
[45] Detecting internally repeated sequences and inferring the history of duplication
1986 • 10 citations
[51] Chromosomal fine mapping of apolipoprotein genes by in situ nucleic acid hybridization to metaphase chromosomes
1986 • 3 citations
[50] Genetic mapping of apolipoprotein genes in the human genome by somatic cell hybrids
1986 • 2 citations
Deleted Work
1955 • 0 citations
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