The ribonucleotide reductases — A unique group of metalloenzymes essential for cell proliferation

The Phylogeny of Prokaryotes

1980 • 1,457 citations

Microbial Iron Compounds

1981 • 1,246 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Hydroxyurea: Inhibitory Effect on DNA Metabolism

1964 • 425 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

1982 • 403 citations

Iron and Free Radical in Ribonucleotide Reductase

1973 • 364 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

Cell-cycle regulation of yeast histone mRNA

1981 • 336 citations

Ribonucleotide Reductase and Cell Proliferation

1970 • 307 citations

Effects of Thymidine on Deoxyribonucleoside Triphosphate Pools and Deoxyribonucleic Acid Synthesis in Chinese Hamster Ovary Cells

1973 • 299 citations

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

1971 • 280 citations

Smooth and efficient deoxygenation of secondary alcohols. A general procedure for the conversion of ribonucleosides to 2'-deoxynucleosides

1981 • 261 citations

Electron Spin Resonance of the Iron-containing Protein B2 from Ribonucleotide Reductase

1972 • 258 citations

Molecular evolution, intracellular organization, and the quinary structure of proteins.

1982 • 244 citations

Biochemistry of Diseases of Immunodevelopment

1981 • 242 citations

Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells

1976 • 242 citations

Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.

1980 • 235 citations

Hydroxyurea

1975 • 234 citations

Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

1981 • 231 citations

Cleavage of deoxyribonucleic acid by the 1,10-phenanthroline-cuprous complex. Hydrogen peroxide requirement and primary and secondary structure specificity

1981 • 230 citations

Regulation of thymidine kinase synthesis in human cells*1

1974 • 215 citations

The tyrosine free radical in ribonucleotide reductase from Escherichia coli.

1978 • 215 citations

The iron center in ribonucleotide reductase from Escherichia coli.

1980 • 215 citations

Single-strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography

1979 • 203 citations

Hydroxyurea

1967 • 198 citations

Effect of hydroxyurea on ribonucleotide reductase

1968 • 196 citations

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism

1983 • 190 citations

Allosteric regulation of calf thymus ribonucleoside diphosphate reductase

1979 • 189 citations

Hydroxamatkomplexe II. Die Anwendung der pH‐Methode

1963 • 185 citations

A permeable animal cell preparation for studying macromolecular synthesis. DNA synthesis and the role of deoxyribonucleotides in S phase initiation

1978 • 178 citations

Physicochemical Characterization of Ribonucleoside Diphosphate Reductase from Escherichia coli

1973 • 172 citations

Chemistry and biology of hydroxamic acids

1982 • 166 citations

Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2.

1980 • 166 citations

Ribonucleotide reductase from calf thymus. Purification and properties

1979 • 166 citations

Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei

1983 • 165 citations

Ribonucleoside Diphosphate Reductase. Purification of the two Subunits, Proteins B1 and B2

1969 • 164 citations

Deoxyribonucleotide Pools and Deoxyribonucleic Acid Synthesis in Cultured Mouse Embryo Cells

1970 • 161 citations

Donor properties of hydroxamic acids

1978 • 159 citations

Cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells

1973 • 156 citations

Nuclear DNA polymerases and the HeLa cell cycle.

1975 • 152 citations

Comparative cytotoxic and biochemical effects of ligands and metal complexes of .alpha.-N-heterocyclic carboxaldehyde thiosemicarbazones

1979 • 150 citations

Nature of the free radical in ribonucleotide reductase from Escherichia coli.

1977 • 148 citations

Naturally occurring non-porphyrin iron compounds

2008 • 148 citations

Ribonucleoside diphosphate reductase

1969 • 146 citations

Further evidence of transcriptional and translational control of histone messenger RNA during the HeLa S3 cycle

1975 • 145 citations

Nuclear and Cytoplasmic Pools of Deoxyribonucleoside Triphosphates in Chinese Hamster Ovary Cells

1974 • 145 citations

Analysis of DNA synthesis during meiotic prophase in Lilium

1971 • 144 citations

Active site of ribonucleoside diphosphate reductase from Escherichia coli. Inactivation of the enzyme by 2'-substituted ribonucleoside diphosphates.

1976 • 143 citations

Formation of Deoxycytidine Phosphates from Cytidine Phosphates in Extracts from Escherichia coli

1961 • 142 citations

Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds

1970 • 141 citations

Reaction Mechanism of Ribonucleoside Diphosphate Reductase from Escherichia coli

1974 • 139 citations

Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein-nucleic acid interactions

1980 • 138 citations

Role of ribonucleotide reductase in expression of the neoplastic program

1981 • 136 citations

Characterization of the free radical of mammalian ribonucleotide reductase.

1982 • 132 citations

Degradation of deoxyribonucleic acid by a 1,10-phenanthroline-copper complex: the role of hydroxyl radicals

1980 • 132 citations

Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction.

1983 • 131 citations

Jack bean urease (EC 3.5.1.5). IV. The molecular size and the mechanism of inhibition by hydroxamic acids. Spectrophotometric titration of enzymes with reversible inhibitors

1980 • 130 citations

.alpha.-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity

1974 • 130 citations

Enzymatic Synthesis of Deoxyribonucleotides

1966 • 125 citations

Studies with hydroxyurea

1966 • 123 citations

Urease Catalysis

1965 • 122 citations

Characterization of the biochemical mechanism of action of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones

1977 • 122 citations

PYRIMIDINE NUCLEOSIDES AS PRECURSORS OF PYRIMIDINES IN POLYNUCLEOTIDES

1950 • 122 citations

Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells.

1981 • 120 citations

Studies on the mechanism of inhibition of redox enzymes by substituted hydroxamic acids

1978 • 118 citations

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 116 citations

Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyurea

1979 • 114 citations

Evidence for a Complex Regulating the in Vivo Activities of Early Enzymes Induced by Bacteriophage T4

1974 • 113 citations

New ribonucleotide reductase inhibitors with antineoplastic activity.

1979 • 112 citations

Cobamide stimulation of the reduction of ribotides to deoxyribotides in LactobacillusLeichmannii

1964 • 109 citations

Thioredoxin: structure and functions

1981 • 108 citations

A substrate radical intermediate in the reaction between ribonucleotide reductase from Escherichia coli and 2'-azido-2'-deoxynucleoside diphosphates.

1983 • 108 citations

Raman spectral evidence for a .mu.-oxo bridge in the binuclear iron center of ribonucleotide reductase

1982 • 108 citations

Biosynthetic evidence for a nickel tetrapyrrole structure of factor F₄₃₀ from Methanobacterium thermoautotrophicum

1980 • 107 citations

Action of hydroxyurea on the nucleic acid metabolism and viability of HeLa cells.

1967 • 105 citations

Regulation of Ribonucleotide Reductase

1981 • 105 citations

Levels of Ribonucleotide Reductase Activity during the Division Cycle of the L Cell

1968 • 103 citations

Interaction of 2-formylpyridine thiosemicarbazonato copper (II) with ehrlich ascites tumor cells

1981 • 102 citations

Ribonucleotide reductase in cultured mouse lymphoma cells. Cell cycle-dependent variation in the activity of subunit protein M2.

1981 • 100 citations

Spectrum and Iron Content of Protein B2 from Ribonucleoside Diphosphate Reductase

1969 • 100 citations

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells.

1982 • 100 citations

Deoxyribonucleoside triphosphate pools in synchronized and drug-inhibited L929 cells

1971 • 98 citations

Ribonucleotide Reductase from Regenerating Rat Liver

1969 • 96 citations

Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells

1981 • 95 citations

Cobamides and ribonucleotide reduction. XI. Direct spectrophotometric observation of an intermediate formed from deoxyadenosylcobalamin in ribonucleotide reduction

1973 • 95 citations

Confounding of Alternate Respiration by Lipoxygenase Activity

1978 • 94 citations

Regulation of thymidylate synthetase in mouse leukemia cells (L1210).

1980 • 94 citations

Mechanism of cobalamin-dependent rearrangements

1975 • 92 citations

The Biosynthesis of Deoxyribonucleotides

1968 • 89 citations

Mechanism of inhibition of ribonucleoside diphosphate reductase by ga-(n)-heterocyclic aldehyde thiosemicarbazones

1971 • 88 citations

The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.

1969 • 88 citations

Characterization of the Active Site of Ribonucleotide Reductase of Escherichia coli, Bacteriophage T4 and Mammalian Cells by Inhibition Studies with Hydroxyurea Analogues

1982 • 88 citations

Ribonucleoside diphosphate reductase from Escherichia coli. An immunological assay and a novel purification from an overproducing strain lysogenic for phage lambdadnrd.

1977 • 88 citations

Hydroxyurea does not prevent synchronized G1 chinese hamster cells from entering the DNA synthetic period

1976 • 87 citations

Structure of the binuclear iron complex in metazidohaemerythrin from Themiste dyscritum at 2.2. Å resolution

1981 • 86 citations

Mechanism of Inhibition of Deoxyribonucleic Acid Synthesis in Escherichia coli by Hydroxyurea

1972 • 85 citations

Cobamides and Ribonucleotide Reduction

1974 • 82 citations

Induction of a new ribonucleotide reductase after infection of mouse L cells with pseudorabies virus

1982 • 82 citations

Binding of substrates to Escherichia coli ribonucleotide reductase.

1976 • 81 citations

Accumulation of single-stranded regions in DNA and the block to replication in a human cell line alkylated with methyl methane sulfonate

1974 • 81 citations

Unique catalytic properties of enzyme clusters

1978 • 81 citations

Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.

1970 • 80 citations

Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents

1981 • 80 citations

Cobamides and ribonucleotide reduction. IX. Monomeric, allosteric enzyme with a single polypeptide chain. Ribonucleotide reductase of Lactobacillus leichmannii

1972 • 79 citations

Ribonucleotide Reductase of Rabbit Bone Marrow

1972 • 79 citations

Kinetics of inactivation of histone mRNA in the cytoplasm after inhibition of DNA replication in synchronised HeLa cells

1975 • 79 citations

Cobamides and Ribonucleotide Reduction

1968 • 78 citations

Assay of ribonucleotide reduction in nucleotide-permeable hamster cells

1978 • 77 citations

Cobamides and Ribonucleotide Reduction

1967 • 74 citations

Ribonucleotide Reductase from Herpes Simplex Virus (Types 1 and 2) Infected and Uninfected KB Cells: Properties of the Partially Purified Enzymes

1977 • 74 citations

On the mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C–H bond cleavage.

1980 • 74 citations

Release of Repressor Control of Ribonucleotide Reductase by Thymine Starvation

1965 • 73 citations

Characterization of Ribonucleotide Reductase Induction in BHK-21/C13 Syrian Hamster Cell Line Upon Infection by Herpes Simplex Virus (HSV)

1981 • 73 citations

Meso-α,β-diphenylsuccinate and Hydroxyurea as Inhibitors of Deoxycytidylate Synthesis in Extracts of Ehrlich Ascites and L Cells

1966 • 72 citations

Comparison of DNA replication and repair enzymology using permeabilized baby hamster kidney cells.

1979 • 71 citations

Mechanism and Regulation of DNA Replication

1974 • 70 citations

Ribonucleotide reductase activity during the cell cycle of Saccharomyces cerevisiae

1973 • 69 citations

Expression of altered ribonucleotide reductase activity associated with the the replication of the epstein-barr virus

1978 • 68 citations

Turnover of the Deoxyribonucleoside Triphosphates in Escherichia coli 15 T during Thymine Starvation

1971 • 67 citations

Intracellular conversions of deoxyribonucleosides by Novikoff rat hepatoma cells and effects of hydroxyurea

1974 • 67 citations

Multienzyme complexes in DNA precursor biosynthesis

1979 • 65 citations

Structure of the tyrosyl radical in bacteriophage T4-induced ribonucleotide reductase.

1982 • 64 citations

B ₁₂ Coenzyme-dependent Ribonucleotide Reductase in Rhizobium Species and the Effects of Cobalt Deficiency on the Activity of the Enzyme

1969 • 64 citations

The Mechanism of Action of Cobamide Coenzyme in the Ribonucleotide Reductase Reaction

1967 • 63 citations

Enhancement of repair replication in mammalian cells by hydroxyurea

1978 • 63 citations

Cell killing and the accumulation of breaks in the DNA of HEp-2 cells incubated in the presence of hydroxyurea.

1970 • 62 citations

Reconstitution of the ribonucleotide reductase enzyme from Ehrlich tumor cells.

1978 • 62 citations

Ribonucleoside Diphosphate Reductase Induced by Bacteriophage T4

1972 • 60 citations

Deoxycytidylate Synthesis and Entry into the Period of Deoxyribonucleic Acid Replication in Rabbit Kidney Cells

1966 • 60 citations

Is ribonucleotide reductase the transforming function of herpes simplex virus 2?

1983 • 59 citations

Specific inhibitors directed at the individual components of ribonucleotide reductase as an approach to combination chemotherapy.

1979 • 59 citations

Ribonucleoside Diphosphate Reductase Induced by Bacteriophage T4

1972 • 59 citations

Deoxyribonucleotide Pools in Mouse‐Fibroblast Cell Lines with Altered Ribonucleotide Reductase

1976 • 58 citations

A new manganese-activated ribonucleotide reductase found in gram-positive bacteria

1981 • 56 citations

Studies on the acid-soluble nucleotide pool in Escherichia coli

1967 • 56 citations

Characteristics of a bacteriophage T4-induced complex synthesizing deoxyribonucleotides.

1982 • 55 citations

Regulation of Cobamide-dependent Ribonucleotide Reductase by Allosteric Effectors and Divalent Cations

1967 • 55 citations

EFFECT OF HYDROXYUREA ON PSEUDOMONAS AERUGINOSA.

1964 • 55 citations

Deoxyribonucleoside Triphosphates in Human Cells: Changes in Disease and Following Exposure to Drugs

1975 • 55 citations

Regulation of ribonucleoside diphosphate reductase synthesis in Escherichia coli: increased enzyme synthesis as a result of inhibition of deoxyribonucleic acid synthesis

1977 • 54 citations

Functional Regulation of Mammalian Ribonucleotide Reductase

1972 • 54 citations

Cobamides and ribonucleotide reduction. VII. Cob(II)alamin as a sensitive probe for the active center of ribonucleotide reductase

1971 • 53 citations

Reduction of cytidine nucleotides to deoxycytidine nucleotides by mammalian enzymes

1962 • 52 citations

Isolation of hydroxyurea-resistant CHO cells with altered levels of ribonucleotide reductase

1979 • 51 citations

Studies on mammalian ribonucleotide reductase inhibition by pyridoxal phosphate and the dialdehyde derivatives of adenosine, adenosine 5'-monophosphate, and adenosine 5'-triphosphate.

1975 • 51 citations

Are DNA precursors concentrated at replication sites?

1982 • 51 citations

Unusual aspects of human thymidylate synthase in mouse cells introduced by DNA-mediated gene transfer.

1983 • 50 citations

Inorganic pyrophosphate is released from 2'-chloro-2'-deoxyuridine 5'-diphosphate by ribonucleoside diphosphate reductase

1980 • 49 citations

Effect of iron-chelating agents on inhibitors of ribonucleotide reductase

1981 • 49 citations

Construction and characterization of hybrid plasmids containing the Escherichia coli nrd region

1980 • 49 citations

Ribonucleotide Reductase from Euglena gracilis, a Deoxyadenosylcobalamin-dependent Enzyme

1970 • 49 citations

Components and control of ribonucleotide reductase system of the rat

1977 • 49 citations

Mapping of nrdA and nrdB in Escherichia coli K-12

1976 • 49 citations

Inhibitor effects during the cell cycle in Chlamydomonas reinhardtii. Determination of transition points in asynchronous cultures.

1975 • 49 citations

Synthesis of yeast histones in the cell cycle.

1976 • 48 citations

Effects of Hydroxyurea on Development and Regeneration

1967 • 48 citations

Ribonucleotide Reductase from Euglena gracilis

1974 • 48 citations

Inability of Escherichia coliB to Incorporate Added Deoxycytidine, Deoxyadenosine, and Deoxyguanosine into DNA

1970 • 47 citations

5′-deoxyadenosylcobalamin-dependent ribonucleotide reductase: A survey of its distribution

1972 • 47 citations

Fractionation and structural elucidation of the active components of aurintricarboxylic acid, a potent inhibitor of protein nucleic acid interactions

1979 • 47 citations

Catalytic function of thymidylate synthase is confined to S phase due to its association with replitase

1982 • 47 citations

Alternative metabolic fates of thymine nucleotides in human cells

1981 • 46 citations

T4 ribonucleotide reductase. Physical and kinetic linkage to other enzymes of deoxyribonucleotide biosynthesis.

1980 • 45 citations

Noncoordinate changes in the components of ribonucleotide reductase in mammalian cells.

1982 • 45 citations

Giant pools of DNA precursors in sea urchin eggs

1975 • 45 citations

Substrate and effector binding to ribonucleoside triphosphate reductase of Lactobacillus leichmannii

1974 • 44 citations

Nature of the G1 phase of the yeast Saccharomyces cerevisiae.

1981 • 44 citations

Studies with hydroxyurea

1968 • 43 citations

Induction of a Reductive Pathway for Deoxyribonucleotide Synthesis during Early Embryogenesis of the Sea Urchin

1972 • 43 citations

Hydroxyurea treatment affects the G1 phase in next generation CHO cells

1977 • 42 citations

Substrate specificity of human ribonucleotide reductase from Molt-4F cells.

1979 • 42 citations

Effect of inhibition of DNA synthesis on histone synthesis and deposition

1978 • 41 citations

Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5'-diphosphate by ribonucleotide reductase.

1972 • 40 citations

The DNA/membrane fraction of Pneumococcus contains a DNA replication complex

1972 • 40 citations

Solubilization and Partial Characterization of a Multienzyme Complex of DNA Synthesis from Human Lymphoblastoid Cells

1982 • 39 citations

A Mutant of Escherichia coli Defective in Ribonucleosidediphosphate Reductase

1973 • 38 citations

Deoxyribonucleoside Triphosphates in Human Cells: Changes in Disease and Following Exposure to Drugs

1975 • 38 citations

Effect of methotrexate and 5-fluorodeoxyuridine on ribonucleotide reductase activity in mammalian cells.

1977 • 38 citations

Comparison of the cytidine 5'-diphosphate and adenosine 5'-diphosphate reductase activities of mammalian ribonucleotide reductase.

1975 • 38 citations

Deoxyribonucleotide synthesis and the emergence of DNA in molecular evolution

1982 • 38 citations

The Biosynthesis of Deoxyribonucleic Acid by the Chick Embryo

1961 • 37 citations

Models of the Regulation of Ribonucleotide Reductase and Their Evaluation in Intact Mammalian Cell

1982 • 36 citations

Characteristics of enzymatic DNA methylation in cultured cells of human and hamster origin, and the effect of DNA replication inhibition

1982 • 36 citations

Independent fluctuations of cytidine and adenosine diphosphate reductase activities in cultured Chinese hamster fibroblasts

1976 • 36 citations

Deoxyribonucleotide Biosynthesis in Synchronous Algae Cells

1980 • 35 citations

Cobamides and Ribonucleotide Reduction. IV. Stereochemistry of Hydrogen Transfer to the Deoxyribonucleotide^*

1967 • 35 citations

Demonstration of two components and association of adenosine diphosphate-cytidine diphosphate reductase from cultured human lymphoblast cells (Molt-4F).

1979 • 35 citations

Synergistic interaction between 1-beta-D-arabinofuranosylcytosine, thymidine, and hydroxyurea against human B cells and leukemic blasts in vitro.

1981 • 35 citations

A Mutant of Escherichia coli Defective in Ribonucleosidediphosphate Reductase

1973 • 35 citations

Postreplication Repair of Ultraviolet Damage to DNA, DNA-Chain Elongation, and Effects of Metabolic Inhibitors in Mouse L Cells

1975 • 34 citations

Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools.

1981 • 34 citations

Alterations of deoxyribonucleoside triphosphate pools in Escherichia coli: effects on deoxyribonucleic acid replication and evidence for compartmentation

1979 • 33 citations

Most of the G1 period in hamster cells is eliminated by lengthening the S period.

1981 • 33 citations

Evidences for the function of DNA polymerase-β in unscheduled DNA synthesis

1979 • 33 citations

Properties of Ribonucleoside Diphosphate Reductase in Nucleotide-Permeable Cells

1973 • 33 citations

Requirement of ribonucleotide reductase for cobamide coenzyme, a product of ribosomal activity.

1965 • 33 citations

Reduction of a Disulphide Bond of Ribonucleotide Reductase by the Dithiol Substrate

1967 • 32 citations

A stable radical in the ribose moiety of X-irradiated 3'-cytidylic acid and its relation to a similar radical in cytidine: an ESR-ENDOR study.

1976 • 32 citations

Isotope-dilution analysis of the effects of deoxyguanosine and deoxyadenosine on the incorpoŕation of thymidine and deoxycytidine by hydroxyurea-treated thymus cells

1980 • 32 citations

Effects of DNA replication inhibitors on UV excision repair in synchronised human cells

1982 • 31 citations

The purification and characterization of an adenosylcobalamin-dependent ribonucleoside diphosphate reductase from Corynebacterium nephridii.

1980 • 31 citations

Studies with Hydroxyurea II. Prolonged Exposure of Escherichia coli to Hydroxyurea

1966 • 31 citations

Ribonucleotide Reductase from Escherichia coli: Demonstration of a Highly Active Form of the Enzyme

1975 • 30 citations

Effect of hydroxyurea and 5-fluorodeoxy-uridine on deoxyribonucleoside triphosphate pools early in phytohemagglutinin-stimulated human lymphocytes

1982 • 30 citations

N‐Carbamoyloxyurea‐resistant Chinese hamster ovary cells with elevated levels of ribonucleotide reductase activity

1981 • 30 citations

Lethal and sublethal effects of hydroxyurea in relation to drug concentration and duration of drug exposure in sarcoma 180 in vitro.

1977 • 30 citations

Deoxycytidylate shortage is a cause of G1 arrest of ascites tumor cells under oxygen deficiency

1983 • 30 citations

Purification and Properties of Ribonucleotide Reductase from Leukemic Mouse Spleen

1970 • 30 citations

Ribonucleotide reductase from saccharomyces cerevisiae

1970 • 30 citations

Ribonucleotide Reductase in Blue-Green Algae: Dependence on Adenosylcobalamin

1976 • 29 citations

Direct photoaffinity labeling of an allosteric site on subunit protein M1 of mouse ribonucleotide reductase by dTTP.

1982 • 29 citations

Adenosylcobalamin-dependent ribonucleotide reductase from the blue-green alga, Anabaena sp. Purification and partial characterization.

1980 • 28 citations

A Stable Radical in the Ribose Moiety of X-Irradiated 3′-Cytidylic Acid and Its Relation to a Similar Radical in Cytidine: An ESR-ENDOR Study

1976 • 28 citations

Urease Activity and Antibiotic Sensitivity of Bacteria

1966 • 28 citations

Rat liver ribonucleotide reductase: separation, purification, and properties of two nonidentical subunits

1982 • 28 citations

On the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Evidence for 3' C–H bond cleavage.

1981 • 28 citations

Bromodeoxyuridine mutagenesis, ribonucleotide reductase activity, and deoxyribonucleotide pools in hydroxyurea-resistant mutants

1981 • 27 citations

Metal complexes of hydroxamic acid analogs

1968 • 27 citations

Hydroxyurea: Induction of breaks in template strands of replicating DNA

1977 • 27 citations

Age-dependent DNA labeling and deoxyribonucleotide synthesis in wheat seeds

1978 • 27 citations

DeoxyATP-resistant ribonucleotide reductase of mutant mouse lymphoma cells. Evidence for heterozygosity for the protein M1 subunits.

1981 • 27 citations

Ribonucleotide reductase from Thermus X-1, a thermophilic organism

1973 • 27 citations

Ribonucleotide Reductase in Developing Brain

1972 • 27 citations

Deoxyribonucleotide synthesis and DNA polymerase activity in plant cells (Vicia faba and Glycine max)

1979 • 26 citations

DNA and histone synthesis in mouse cells which exhibit temperature-sensitive DNA synthesis

1980 • 26 citations

Chain elongation and joining of DNA synthesized during hydroxyurea treatment of Chinese hamster cells

1976 • 26 citations

Tight coordination of ribonucleotide reduction and thymidylate synthesis in synchronous algae

1983 • 25 citations

Comparison of purine and pyrimidine metabolism in G₁ and S phases of HeLa and Chinese hamster ovary cells

1982 • 25 citations

ACTION OF HYDROXYUREA AND N‐CARBAMOYLOXYUREA ON THE CELL CYCLE OF TETRAHYMENA

1973 • 25 citations

Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy

1981 • 24 citations

Ribonucleotide reductase activity in vitamin B12-deficient Euglena gracilis

1980 • 24 citations

Inhibition of DNA synthesis and cell death

1982 • 24 citations

Properties of ribonucleotide reductase from Ehrlich tumor cells; multiple nucleoside diphosphate activities and reconstitution of activity from components

1979 • 24 citations

The effect of hydroxyurea on the mechanism of DNA synthesis in the yeast Saccharomyces cerevisiae

1980 • 24 citations

Interaction of ribonucleotide reductase with ribonucleotide analogs

1971 • 24 citations

Studies on ribonucleoside-diphosphate reductase in permeable animal cells

1982 • 24 citations

Studies with hydroxyurea VI. Effects of hydroxyurea on the metabolism of sensitive and resistant strains of Escherichia coli

1967 • 24 citations

Coordinate control of the synthesis of ribonucleoside diphosphate reductase components in Escherichia coli

1977 • 23 citations

Enzymes of DNA biosynthesis in developing sea urchins

1976 • 23 citations

Ribonucleotide reductase activity in green algae

1976 • 23 citations

On the mechanism of premeiotic DNA synthesis in the yeast Saccharomyces cerevisiae

1982 • 23 citations

Hydroxyurea-resistant mouse L cells with elevated levels of drug-resistant ribonucleotide reductase activity

1980 • 23 citations

In vivo cell cycle synchronization of the murine sarcoma 180 tumor following alternating periods of hydroxyurea blockade and release.

1979 • 23 citations

Ribonucleotide reduction and the possible role of cobalamin in evolution

1977 • 23 citations

Aphidicolin sensitivity of variant 3T6 cells selected for changes in ribonucleotide reductase

1981 • 23 citations

Analysis of the interphase accumulation induced by hydroxyurea on proliferating plant cells

1979 • 22 citations

Regulation of fungal ribonucleotide reductase by unusual dinucleotides

1976 • 22 citations

Purification of the two complementary subunits of ribonucleotide reductase from calf thymus

1981 • 22 citations

Mode of inhibition of tumor cell ribonucleotide reductase by 2,3-dihydro-1H-pyrazolo[2,3-a]imidazole (NSC 51143).

1980 • 22 citations

Relationship between chromatin structure and replication in mouse L-cells

1980 • 22 citations

The molecular weight of Ehrlich tumor cell ribonucleotide reductase and its subunits: Effector-induced changes

1982 • 22 citations

[31] Ribonucleotide reductase of rabbit bone marrow

1978 • 22 citations

Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells.

1980 • 22 citations

Studies of mammalian ribonucleotide reductase activity in intact permeabilized cells: A genetic approach

1981 • 22 citations

Inhibition of mammalian ribonucleotide reductase by a dinucleotide produced in eucaryotic cells

1977 • 21 citations

Raman and infrared spectroscopy of the oxo-bridged iron(III) complex, [Cl3Fe_O_FeCl3]−2 as a spectroscopic model for the oxo bridge in hemerythrin and ribonucleotide reductase

1982 • 21 citations

Amino acid hydroxamates as inhibitors of the human enkephalin-degrading aminopeptidase

1982 • 21 citations

The enzymatic reduction of ribonucleotides

2007 • 21 citations

The organization of DNA metabolism during the recombinational phase of meiosis with special reference to humans

1980 • 21 citations

Effect of hydroxyurea on T4 ribonucleotide reductase.

1979 • 21 citations

Effects of hydroxyurea on DNA synthesis in mouse L-cells

1982 • 21 citations

Characterization of a high activity form of ribonucleoside diphosphate reductase from Escherichia coli.

1979 • 20 citations

Phosphorylated guanosine derivatives of eukaryotes: Regulation of DNA-dependent RNA polymerases I, II, and III in fungal development

1975 • 20 citations

Evidence for the reductive pathway of deoxyribonucleotide synthesis in an archaebacterium

1981 • 20 citations

Sequential biochemical events related to DNA replication in the regenerating rat liver

1974 • 20 citations

Mechanism of B12-dependent ribonucleotide reductase

1983 • 20 citations

The Bacillus megaterium ribonucleotide reductase: Evidence for a B12 coenzyme requirement

1973 • 19 citations

Effects of the ferrous chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the kinetics of reduction of CDP by ribonucleotide reductase of the Novikoff tumor.

1980 • 18 citations

Ribonucleotide reduction in intact human diploid fibroblasts

1980 • 18 citations

4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a second-generation antineoplastic agent of the alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone series.

1977 • 18 citations

The oxidation of hydroxamic acids

1966 • 18 citations

Diguanosine nucleotides of fungi that regulate RNA polymerases isolated and partially characterised

1975 • 18 citations

Direct photoaffinity labeling of an allosteric site of subunit protein M1 of mouse ribonucleotide reductase by dATP. Evidence for two independent binding interactions within the allosteric specificity site.

1982 • 18 citations

Ribonucleotide reductase from Escherichia coli. Identification of allosteric effector sites by chromatography on immobilized effectors

1977 • 17 citations

Control by Bacteriophage T4 of the Reduction of Adenosine Nucleotide to Deoxyadenosine Nucleotide

1972 • 17 citations

Enzymic preparation of the 5'-triphosphates of 2'-deoxytubercidin, 2'-deoxytoyocamycin, and 2'-deoxyformycin and the allosteric effects of these nucleotides on ribonucleotide reductase

1978 • 17 citations

Affinity adsorbent containing deoxyguanosine 5'-triphosphate linked to sepharose and its use for large scale preparation of ribonucleotide reductase of Lactobacillus leichmannii

1975 • 17 citations

Ribonucleotide reductase isolated from human cells

1978 • 17 citations

Cytidine 5′-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

1979 • 17 citations

Increased synthesis of ribonucleotide reductase after deoxyribonucleic acid inhibition in various species of bacteria

1979 • 17 citations

The biosynthesis of DNA by insects

1971 • 17 citations

Synthèse des 1-(5-dèsoxy-β-D-ribo-hexofuranosyl)cytosine et 1-(2,5-didèsoxy-β-D-érythro-hexofuranosyl)cytosine, et de leurs phosphates. Contribution à l'étude de la spécificité d'une ribonucléotide-réductase de mammifère (rat)

1979 • 17 citations

The Specificity of Ribonucleoside Triphosphate Reductase

1978 • 17 citations

Deoxyribonucleoside-requiring Mutants of Bacillus subtilis

1978 • 17 citations

Inhibition of ribonucleotide reductase from Ehrlich tumor cells by RNA.

1973 • 17 citations

Hydroxamic acid oxidation-pharmacological considerations

1978 • 16 citations

DNA Polymerases and a Possible Multi-Enzyme Complex for DNA Biosynthesis in Eukaryotes

1974 • 16 citations

Analysis of the electron paramagnetic resonance spectrum of the cobalamin intermediate in ribonucleotide reduction

1976 • 16 citations

Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotides reductase from Escherichia coli

1982 • 16 citations

Relationship between ribo- and deoxyribonucleotide concentrations and biological parameters in cultured chinese hamster ovary cells

1982 • 16 citations

Ribonucleotide reductase activity in cell-free extracts of Yaba poxvirus tumor and normal monkey tissues.

1969 • 15 citations

Deoxynucleoside Kinases of Bacillus megaterium KM

1971 • 14 citations

Ribonucleotide Reductase of Pithomyces chartarum: Requirement for B12 Coenzyme

2000 • 14 citations

Distribution of DNA or DNA synthesis in mammalian cells following inhibition with hydroxyurea and 5-fluorodeoxyuridine

1975 • 14 citations

Hydroxyurea inhibits ODC induction, but not the G1 to S phase transition

1979 • 14 citations

Ribonucleotide reductase. Studies with oxygen-18-labeled substrates

1969 • 14 citations

Mechanism of Lactobacillus leichmannii ribonucleotide reductase studied with Co.alpha.[.alpha.-(aden-9-yl)]-Co.beta.-adenosylcobamide (pseudocoenzyme B12)

1979 • 14 citations

Isolation of naturally occurring inhibitors of ribonucleotide reductase

1970 • 13 citations

The nature of unbalanced cell growth caused by cytotoxic agents

1981 • 13 citations

Hydroxyurea and Escherichia coli nucleoside diphosphate reductase.

1970 • 13 citations

Inhibition of thymidylate synthase by hydroxyurea in rapidly proliferating P815 mastocytoma cells

1982 • 13 citations

Hydroxyurea inhibition of greening, macromolecule synthesis and cell division in Euglena gracilis

1967 • 12 citations

In Situ Activity of Enzymes on Polyacrylamide Gels of a Deoxyribonucleic Acid-Membrane Fraction Extracted from Pneumococci

1974 • 12 citations

The electron spin resonance spectra of some hydroxylamine free radicals. Part II. Radicals formed in acid solution from hydroxamic acids

1966 • 12 citations

Recovery from vitamin B-12-induced unbalanced growth. The shortened cell cycle and the deoxyribonucleoside triphosphate pools

1978 • 12 citations

The Cell Cycle in the Fission Yeast, <I>Schizosaccharomyces pombe</I>. III. Cycle Durations in Synchronized Cells Produced by Hydroxyurea

1979 • 12 citations

In vivo photoinactivation of Escherichia coli ribonucleotide reductase by near-ultraviolet light

1977 • 12 citations

Ribonucleotide reductase activity during amphibian development

1975 • 11 citations

Thymidine-requiring mutants of Salmonella typhimurium that are defective in deoxyuridine 5'-phosphate synthesis

1977 • 11 citations

Radical reactions in the coordination field of transition metals. VII—H-transfer between phenolic and aryl-aminic H-donors and their radicals

1980 • 11 citations

Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)

1980 • 11 citations

Evidence for the resumption of DNA replication prior to histone synthesis in HeLa cells after release from treatment with hydroxyurea

1982 • 11 citations

Altered glycosaminoglycan composition of rat forelimb‐buds during hydroxyurea teratogenesis: An indication of repair

1982 • 11 citations

Sur la stéréospécificité de la ribonucléoside-diphosphate-réductase: préparation de désoxyribonucléosides pyrimidiques deutérés

1971 • 11 citations

Ribonucleotide reductase activity in ether-treated cells of Agmenellum quadruplicatum

1976 • 10 citations

Effects of azidocytidine on DNA synthesis and deoxynucleotide pools of mouse fibroblast cell lines.

1982 • 9 citations

The Cytidine Diphosphate Reductase System.

1963 • 9 citations

PH stepwise alkaline elution of DNA replication intermediates during S phase

1981 • 9 citations

Characterization of Ribonucleotide Reductase Activity from Mouse L Cells

1979 • 9 citations

Bacteriophage‐Induced Ribonucleotide Reductase Systems

1974 • 9 citations

Influence of effectors on the rate of reaction of reduced ribonucleoside triphosphate reductase with N-ethylmaleimide

1977 • 8 citations

In vitro generation of ribonucleotide reductase with altered sensitivity to the inhibitors hydroxyurea and deoxynucleoside triphosphates

1981 • 8 citations

Glucose transport in Achlya: Characterization and possible regulatory aspects

1978 • 8 citations

BIOLOGICAL EFFECTS OF AZOMYCIN (2-NITRO-IMIDAZOLE): INHIBITION OF RIBONUCLEOTIDE REDUCTASE

1974 • 7 citations

Inhibition of Bacterial Ribonucleotide Reductases by Arabinonucleotides

1978 • 7 citations

Effects of Hydroxyurea and Deoxyadenosine on the Synthesis of Deoxycytidine Phosphate and on the Uptake of Nucleosides in Excised Root Tips of Vicia faba

1971 • 7 citations

Possible regulation of macromolecular biosynthesis in mammalian cells by a novel dinucleoside polyphosphate (HS3) produced during step‐down growth conditions

1977 • 7 citations

A degradation product of fenitrothion, 3-methyl-4-nitrophenol, is an inhibitor of mammalian ribonucleotide reductase

1982 • 6 citations

Control of ribonucleotide reductase in Synechococcus Sp., a unicellular cyanobacterium

1979 • 6 citations

Effect of hydroxyurea and trisethyleneiminobenzoquinone (Trenimon) on the methylation of DNA in Ehrlich ascites tumor cells

1972 • 6 citations

Effects of <scp>L</scp>-glutamine and HS compounds on growth and sporulation metabolism of Achlya

1978 • 6 citations

Possible regulation of nucleoside transport and RNA synthesis in Achlya

1978 • 5 citations

Studies of inhibition of deoxynucleotide synthesis in chick embryos

1968 • 4 citations

Distribution of ribonucleotide reductase in the genusSynechococcus

1978 • 4 citations

Studies on a membrane-bound and solubilized ribonucleotide reductase preparation from Escherichia coli Tau−

1979 • 4 citations

Ribonucleoside 5′‐thiodiphosphates as Substrates for Escherichia coli Ribonucleotide Reductase

1974 • 4 citations

Steuermechanismen der Ribonucleotid-Reduktion in S�ugetiergewebe

1978 • 3 citations

Recharacterization of fungal dinucleoside polyphosphate (HS3)

1978 • 3 citations