Mechanism of Inhibition of Deoxyribonucleic Acid Synthesis in Escherichia coli by Hydroxyurea

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter

1960 • 7,610 citations

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

Sedimentation Rate as a Measure of Molecular Weight of DNA

1963 • 741 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Replication and Repair of DNA in Cells of Escherichia coli Treated with Toluene

1970 • 326 citations

Hydroxyurea

1967 • 198 citations

Effect of hydroxyurea on ribonucleotide reductase

1968 • 196 citations

Resolution of complex nucleotide mixtures by two-dimensional anion-exchange thin-layer chromatography

1964 • 172 citations

Ion-exchange thin-layer chromatography

1965 • 172 citations

Studies with hydroxyurea

1966 • 123 citations

A new DNA polymerase activity of Escherichia coli. I. Purification and properties of the activity present in E. coli polAl

1970 • 107 citations

Spectrum and Iron Content of Protein B2 from Ribonucleoside Diphosphate Reductase

1969 • 100 citations

Inhibition of DNA synthesis by hydroxyurea: structure-activity relationships.

1967 • 100 citations

Isolation of Bacteriophage T4 Mutants Defective in the Ability to Degrade Host Deoxyribonucleic Acid

1970 • 96 citations

The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.

1969 • 88 citations

Ion-exchange thin-layer chromatography

1965 • 80 citations

Studies on the acid-soluble nucleotide pool in thymine-requiring mutants of Escherichia coli during thymine starvation

1966 • 75 citations

THE ACTION OF HYDROXYUREA ON MOUSE L‐CELLS*

1969 • 75 citations

Turnover of the Deoxyribonucleoside Triphosphates in Escherichia coli 15 T during Thymine Starvation

1971 • 67 citations

B ₁₂ Coenzyme-dependent Ribonucleotide Reductase in Rhizobium Species and the Effects of Cobalt Deficiency on the Activity of the Enzyme

1969 • 64 citations

Enzymes of Nucleic Acid Metabolism

1970 • 62 citations

On the Process of Cellular Division in Escherichia coli , V. Incorporation of Deoxynucleoside Triphosphates by DNA Thermosensitive Mutants of Escherichia coli Also Lacking DNA Polymerase Activity

1970 • 57 citations

Studies on the acid-soluble nucleotide pool in Escherichia coli

1967 • 56 citations

EFFECT OF HYDROXYUREA ON PSEUDOMONAS AERUGINOSA.

1964 • 55 citations

The Effect of Cupric Ions on the Indole Reaction for the Determination of Deoxyribonucleic Acid

1968 • 49 citations

Significance of Ribonucleotide Reduction in the Biosynthesis of Deoxyribonucleotides in Escherichia coli

1967 • 47 citations

Inability of Escherichia coliB to Incorporate Added Deoxycytidine, Deoxyadenosine, and Deoxyguanosine into DNA

1970 • 47 citations

Control of pyrimidine biosynthesis by phage T4: Mutants unable to catalyze the reduction of cytidine diphosphate

1969 • 44 citations

Effect of Hydroxyurea on Replication of Bacteriophage T4 in Escherichia coli

1969 • 43 citations

Studies with hydroxyurea

1968 • 43 citations

Effects of disintegration of incorporated 3H and 32P on the physical and biological properties of DNA

1970 • 41 citations

Detection of a reactive intermediate in the reaction between DNA and hydroxyurea.

1970 • 38 citations

Cobamides and Ribonucleotide Reduction. IV. Stereochemistry of Hydrogen Transfer to the Deoxyribonucleotide^*

1967 • 35 citations

Studies with hydrogen isotopes on the mechanism of action of cobamide-dependent ribonucleotide reductase

1966 • 30 citations

Studies with hydroxyurea VI. Effects of hydroxyurea on the metabolism of sensitive and resistant strains of Escherichia coli

1967 • 24 citations

Degradation of DNA by carbamoyloxyurea — An oxidation product of hydroxyurea

1969 • 21 citations

Transfer of hydrogen in the cobamide-dependent ribonucleotide reductase reaction

1966 • 21 citations

CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.

1964 • 21 citations

Metal complexes of 1-substituted 3-hydroxyureas

1970 • 14 citations

Hydroxyurea and Escherichia coli nucleoside diphosphate reductase.

1970 • 13 citations

Effects of N -Hydroxyurethan on Viability and Metabolism of Escherichia coli

1971 • 12 citations

Antagonism by deoxyribosides of the inhibitory action of certain hydroxamic acids on deoxyribonucleic acid synthesis

1968 • 9 citations